Exploring embodied experience via videoconferencing: A method for body mapping online

Faced with a series of COVID-19 related lockdowns in Australia across 2020 and 2021, and anxious about the safety of our research participants, we developed a novel approach to body mapping, an arts-based research method typically undertaken in-person. We produced a facilitated body mapping workshop hosted via an online videoconferencing platform. Workshops brought together 29 participants with disability, mental distress and/or refugee background who used body mapping to represent their embodied experiences of stigma and discrimination. These workshops generated rich data, and participants reported a high level of satisfaction with the process. In this paper we describe our novel approach to body mapping, and share practical tips for others who wish to undertake body mapping remotely. We outline strengths associated with this method: increased accessibility, enhanced connection between participants, the formation of a space to explore challenging subject matter, the production of rich data, and the creation of diverse body maps. We also discuss shortcomings and challenges which those considering the method should be aware of: increased logistical burden, demands related to space, IT difficulties, the danger of over-sharing, and diminished cohort sizes. To our knowledge, this is the first paper to report on body mapping facilitated via web-based workshops. Here, we seek to provide practical advice and useful insights for others hoping to utilise body mapping online

Effectiveness, safety, and acceptability of medical abortion at home vs. in the clinic: An updated systematic review in response to COVID-19

This document describes the protocol for an updated systematic review of the evidence comparing medical abortion practiced at home and in clinics in terms of effectiveness, safety and acceptability. We are updating Ngo et al.’s 2011 review given the importance of access to homemedication abortion during the COVID-19 pandemic. We will conduct a systematic search for randomized controlled trials and prospective cohort studies comparing home-based and clinic-based medical abortion. Successful abortion is the main outcome of interest. Side-effects, complications, and acceptability are secondary outcomes. Risk Ratios (RRs) and their 95% confidence intervals (CIs) will be calculated. Estimates will be pooled using a random-effects model

Post-Acute Sequelae of COVID-19 (PASC) in Pediatrics: Factors That Impact Symptom Severity and Referral to Treatment.

The post-acute sequelae of COVID-19 (PASC) is a complex condition. While there are emerging studies on its effects in adults, there is scarce research regarding the long-term effects of COVID-19 infection among youth. Several researchers have likened long-haul COVID-19 to chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and postural orthostatic tachycardia syndrome (POTS). In adults, the prognosis for these diagnoses is less promising than that in youth; however, there is currently very little information available on the presentation of youth with PASC. A better understanding of the specific symptom presentation for youth diagnosed with PASC is necessary. Retrospective chart reviews were conducted collecting demographic data, COVID-19 symptoms and disease progression, and vaccination status. Additional data on referrals to a PASC treatment program and appointments attended were collected. Overall, data suggested that youth present with less severe PASC symptoms than adults, and the role of vaccination is unclear. These youth are often not referred to treatment programs. More exploration is necessary to continue to build an understanding of how best to aid youth diagnosed with PASC

Mapping Stigma and Resilience: Body maps created for the Women marginalised by mental health, disability, or refugee background project.

This is a catalogue of stories; true stories courageously told and generously shared. Stories formed from paint, pens, fabric, and glue. Stories fashioned from voice and word. They were articulated during the Women marginalised by mental health, disability, or refugee background research project (affectionally nicknamed Women and Body Mapping Stigma by the research team)

New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.

Nontyphoidal Salmonella (NTS), particularly Salmonella enterica serovar Typhimurium, is among the leading etiologic agents of bacterial enterocolitis globally and a well-characterized cause of invasive disease (iNTS) in sub-Saharan Africa. In contrast, S Typhimurium is poorly defined in Southeast Asia, a known hot spot for zoonotic disease with a recently described burden of iNTS disease. Here, we aimed to add insight into the epidemiology and potential impact of zoonotic transfer and antimicrobial resistance (AMR) in S Typhimurium associated with iNTS and enterocolitis in Vietnam. We performed whole-genome sequencing and phylogenetic reconstruction on 85 human (enterocolitis, carriage, and iNTS) and 113 animal S Typhimurium isolates isolated in Vietnam. We found limited evidence for the zoonotic transmission of S Typhimurium. However, we describe a chain of events where a pandemic monophasic variant of S Typhimurium (serovar I:4,[5],12:i:- sequence type 34 [ST34]) has been introduced into Vietnam, reacquired a phase 2 flagellum, and acquired an IncHI2 multidrug-resistant plasmid. Notably, these novel biphasic ST34 S Typhimurium variants were significantly associated with iNTS in Vietnamese HIV-infected patients. Our study represents the first characterization of novel iNTS organisms isolated outside sub-Saharan Africa and outlines a new pathway for the emergence of alternative Salmonella variants into susceptible human populations.IMPORTANCESalmonella Typhimurium is a major diarrheal pathogen and associated with invasive nontyphoid Salmonella (iNTS) disease in vulnerable populations. We present the first characterization of iNTS organisms in Southeast Asia and describe a different evolutionary trajectory from that of organisms causing iNTS in sub-Saharan Africa. In Vietnam, the globally distributed monophasic variant of Salmonella Typhimurium, the serovar I:4,[5],12:i:- ST34 clone, has reacquired a phase 2 flagellum and gained a multidrug-resistant plasmid to become associated with iNTS disease in HIV-infected patients. We document distinct communities of S Typhimurium and I:4,[5],12:i:- in animals and humans in Vietnam, despite the greater mixing of these host populations here. These data highlight the importance of whole-genome sequencing surveillance in a One Health context in understanding the evolution and spread of resistant bacterial infections

Summary for policymakers of the global assessment report on biodiversity and ecosystem services of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services

Fil: Díaz, Sandra. Universidad Nacional de Córdoba. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Díaz, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Settele, Josef. Helmholtz-Zentrum für Umweltforschung. Department of Community Ecology; Alemania.Fil: Brondízio, Eduardo. Indiana University Bloomington. Department of Anthropology; Estados Unidos.Fil: Ngo, Hien T. Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services; Alemania.Fil: Guèze, Maximilien. Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services; Alemania.Fil: Agard, John. University of the West Indies. Department of Life Sciences; Trinidad y Tobago.Fil: Arneth, Almut. Karlsruhe Institute of Technology. Institute of Meteorology and Climate Research. Atmospheric Environmental Research; Alemania.Fil: Balvanera, Patricia. Universidad Nacional Autónoma de México. Instituto de Investigaciones en Ecosistemas y Sustentabilidad; México.Fil: Brauman, Kate A. University of Minnesota. Institute on the Environment; Estados Unidos.Fil: Butchart, Stuart H. M. BirdLife International; Reino Unido.Fil: Chan, Kai. University of British Columbia. Institute for Resources, Environment and Sustainability; Canada.Fil: Garibaldi, Lucas Alejandro. Universidad Nacional de Río Negro. Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural; Argentina.Fil: Garibaldi, Lucas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural; Argentina.Fil: Ichii, Kazuhito. National Institute for Environmental Studies. Center for Global Environmental Research; Japón.Fil: Liu, Jianguo. Michigan State University. Center for Systems Integration and Sustainability; Estados Unidos.Fil: Mazhenchery Subramanian, Suneetha. United Nations University. Institute of Advanced Studies; Japón.Fil: Midgley, Guy. Stellenbosch University. Department of Botany and Zoology; Sudáfrica.Fil: Miloslavich, Patricia. Commonwealth Scientific and Industrial Research Organisation. Oceans and Atmosphere; Australia.Fil: Molnár, Zsolt. Hungarian Academy of Sciences. Traditional Ecological Knowledge Research Group; Hungría.Fil: Obura, David. Coastal Oceans Research and Development – Indian Ocean; Kenya.Fil: Pfaff, Alexander. Duke University; Estados Unidos.Fil: Polasky, Stephen. University of Minnesota. Department of Applied Economics; Estados Unidos.Fil: Purvis, Andy. Natural History Museum. Department of Life Sciences; Reino Unido.Fil: Razzaque, Jona. University of the West of England. Faculty of Business and Law. Department of Law; Reino Unido.Fil: Reyers, Belinda. Stellenbosch University. Department of Conservation Ecology; Sudáfrica.Fil: Roy Chowdhury, Rinku. Clark University. Graduate School of Geography; Estados Unidos.Fil: Shin, Yunne J. Institute of Research for Development, Sète & Montpellier; Francia.Fil: Visseren Hamakers, Ingrid. George Mason University. Department of Environmental Science and Policy; Estados Unidos.Fil: Willis, Katherine. University of Oxford. Department of Zoology; Reino Unido.Fil: Zayas, Cynthia N. University of the Philippines. Center for International Studies; Filipinas.Summary for policymakers of the global assessment report on biodiversity and ecosystem services of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services

The global assessment report on biodiversity and ecosystem services: Summary for policy makers

This report represents a critical assessment, the first in almost 15 years (since the release of the Millennium Ecosystem Assessment in 2005) and the first ever carried out by an intergovernmental body, of the status and trends of the natural world, the social implications of these trends, their direct and indirect causes, and, importantly, the actions that can still be taken to ensure a better future for all. These complex links have been assessed using a simple, yet very inclusive framework that should resonate with a wide range of stakeholders, since it recognizes diverse world views, values and knowledge systems.Fil: Díaz, Sandra Myrna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Settele, Josef. Helmholtz Centre for Environmental Research; AlemaniaFil: Brondízio, Eduardo. Indiana University; Estados UnidosFil: Ngo, Hien. Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services; AlemaniaFil: Guèze, Maximilien. Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services; AlemaniaFil: Agard, John. University of The West Indies; Trinidad y TobagoFil: Arneth, Almut. Karlsruher Institut fur Technologie; AlemaniaFil: Balvanera, Patricia. Universidad Nacional Autónoma de México; MéxicoFil: Brauman, Kate. University of Minnesota; Estados UnidosFil: Butchart, Stuart. University of Cambridge; Reino UnidoFil: Chan, Kai M. A.. University of British Columbia; CanadáFil: Garibaldi, Lucas Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Patagonia Norte. Instituto de Investigaciones En Recursos Naturales, Agroecologia y Desarrollo Rural. - Universidad Nacional de Rio Negro. Instituto de Investigaciones En Recursos Naturales, Agroecologia y Desarrollo Rural.; ArgentinaFil: Ichii, Kazuhito. Chiba University; JapónFil: Liu, Jianguo. Michigan State University; Estados UnidosFil: Subramanian, Suneetha. United Nations University; JapónFil: Midgley, Guy. Stellenbosch University; SudáfricaFil: Miloslavich, Patricia. Universidad Simon Bolivar.; VenezuelaFil: Molnár, Zsolt. Hungarian Academy of Sciences; HungríaFil: Obura, David. Coastal Oceans Research and Development Indian Ocean; KeniaFil: Pfaff, Alexander. University of Duke; Estados UnidosFil: Polasky, Stephen. University of Minnesota; Estados UnidosFil: Purvis, Andy. Natural History Museum; Reino UnidoFil: Razzaque, Jona. University of the West of England; Reino UnidoFil: Reyers, Belinda. Stellenbosch University; SudáfricaFil: Roy Chowdhury, Rinku. Clark University; Estados UnidosFil: Shin, Yunne-Jai. Centre National de la Recherche Scientifique; FranciaFil: Visseren-Hamakers, Ingrid. Radboud Universiteit Nijmegen; Países BajosFil: Willis, Katherine. University of Oxford; Reino UnidoFil: Zayas, Cynthia. University of the Philippines; Filipina

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155922/1/pmic13292_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155922/2/pmic13292.pd

Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts.

Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airway obstruction and accelerated lung function decline. Our understanding of systemic protein biomarkers associated with COPD remains incomplete. Objectives: To determine what proteins and pathways are associated with impaired pulmonary function in a diverse population. Methods: We studied 6,722 participants across six cohort studies with both aptamer-based proteomic and spirometry data (4,566 predominantly White participants in a discovery analysis and 2,156 African American cohort participants in a validation). In linear regression models, we examined protein associations with baseline forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). In linear mixed effects models, we investigated the associations of baseline protein levels with rate of FEV1 decline (ml/yr) in 2,777 participants with up to 7 years of follow-up spirometry. Results: We identified 254 proteins associated with FEV1 in our discovery analyses, with 80 proteins validated in the Jackson Heart Study. Novel validated protein associations include kallistatin serine protease inhibitor, growth differentiation factor 2, and tumor necrosis factor-like weak inducer of apoptosis (discovery β = 0.0561, Q = 4.05 × 10-10; β  = 0.0421, Q = 1.12 × 10-3; and β = 0.0358, Q = 1.67 × 10-3, respectively). In longitudinal analyses within cohorts with follow-up spirometry, we identified 15 proteins associated with FEV1 decline (Q < 0.05), including elafin leukocyte elastase inhibitor and mucin-associated TFF2 (trefoil factor 2; β = -4.3 ml/yr, Q = 0.049; β = -6.1 ml/yr, Q = 0.032, respectively). Pathways and processes highlighted by our study include aberrant extracellular matrix remodeling, enhanced innate immune response, dysregulation of angiogenesis, and coagulation. Conclusions: In this study, we identify and validate novel biomarkers and pathways associated with lung function traits in a racially diverse population. In addition, we identify novel protein markers associated with FEV1 decline. Several protein findings are supported by previously reported genetic signals, highlighting the plausibility of certain biologic pathways. These novel proteins might represent markers for risk stratification, as well as novel molecular targets for treatment of COPD