This document describes the protocol for an updated systematic review of the evidence comparing medical abortion practiced at home and in clinics in terms of effectiveness, safety and acceptability. We are updating Ngo et al.’s 2011 review given the importance of access to homemedication abortion during the COVID-19 pandemic. We will conduct a systematic search for randomized controlled trials and prospective cohort studies comparing home-based and clinic-based medical abortion. Successful abortion is the main outcome of interest. Side-effects, complications, and acceptability are secondary outcomes. Risk Ratios (RRs) and their 95% confidence intervals (CIs) will be calculated. Estimates will be pooled using a random-effects model
