XMLText: From XML Schema to Xtext

A multitude of Domain-Specific Languages (DSLs) have been implemented with XML Schemas. While such DSLs are well adopted and flexible, they miss modern DSL editor functionality. Moreover, since XML is primarily designed as a machine-processible format, artifacts defined with XMLbased DSLs lack comprehensibility and, therefore, maintainability. In order to tackle these shortcomings, we propose a bridge between the XML Schema Definition (XSD) language and text-based metamodeling languages. This bridge exploits existing seams between the technical spaces XMLware, modelware, and grammarware as well as closes identified gaps. The resulting approach is able to generate Xtextbased editors from XSDs providing powerful editor functionality, customization options for the textual concrete syntax style, and round-trip transformations enabling the exchange of data between the involved technical spaces. We evaluate our approach by a case study on TOSCA, which is an XML-based standard for defining Cloud deployments. The results show that our approach enables bridging XMLware with modelware and grammarware in several ways going beyond existing approaches and allows the automated generation of editors that are at least equivalent to editors manually built for XML-based languages.European Commission ICT Policy Support Programme 31785

Reciprocal relations of subjective sleep quality and affective well-being in late childhood

High sleep quality has been associated with beneficial outcomes across the life span. Intensive longitudinal studies suggest that these beneficial effects can also be observed on a day-to-day level. However, the dynamic interplay between subjective sleep quality and affective well-being in children\u27s daily life has only rarely been investigated. The aims of the present work were (a) to replicate findings from a prior ambulatory assessment study in this area (Könen et al., 2016), (b) to explore the effect of subjective sleep quality on well-being throughout the day, and (c) to examine the reciprocal relation between subjective sleep quality and well-being in more detail. Data from two ambulatory assessment studies with children between 8 and 11 years (N = 108/84, with assessments over 28/21 consecutive days) consistently showed that positive affect was higher and negative affect was lower after nights with better sleep quality, and that the effects of subjective sleep quality were stronger on well-being assessed in the morning compared with later in the day. Results from dynamic structural equation models revealed reciprocal effects of subjective sleep quality and positive affect. Negative affect was not consistently related to worse subsequent sleep quality after controlling for positive affect and prior night\u27s sleep quality. Results suggest a close relation of sleep quality and positive affect, which strengthens the idea behind interventions targeting both, children\u27s sleep and well-being. Differences between children in the dynamic interplay between sleep and affect may be important predictors of long-term outcomes. (DIPF/Orig.

Implementierung und Einsatz eines einheitlichen Lehramt-Aufnahmeverfahrens im Verbund

Seit 2014 wurde an der Universität Graz gemeinsam mit und für den „Verbund Aufnahmeverfahren“ ein wissenschaftlich fundiertes, einheitliches Aufnahme- und Auswahlverfahren für Lehramtsstudien an Pädagogischen Hochschulen und Universitäten entwickelt. Das mehrstufige Verfahren zur Feststellung der persönlichen Eignung der Bewerber/innen wurde als standardisierter Gesamtprozess umgesetzt und technisch und administrativ so implementiert, dass es Fairness, Transparenz und Flexibilität für die Studienwerber/innen und praktikable, effiziente und ressourcenschonende Abläufe für die Institutionen im „Verbund Aufnahmeverfahren“ bietet. Im folgenden Werkstattbericht werden sowohl die Entwicklung und Durchführung als auch die technische und inhaltliche Umsetzung dargestellt

Integrating Geophysical and Photographic Data to Visualize the Quarried Structures of the Roman Town of Bassianae

Large parts of the urban layout of the abandoned Roman town of Bassianae (in present-day Serbia) are still discernible on the surface today due to the deliberate and targeted quarrying of the Roman foundations. In 2014, all of the town's intramural (and some extramural) areas were surveyed using aerial photography, ground-penetrating radar, and magnetometry to analyze the site's topography and to map remaining buried structures. The surveys showed a strong agreement between the digital surface model derived from the aerial photographs and the geophysical prospection data. However, many structures could only be detected by one method, underlining the benefits of a complementary archaeological prospection approach using multiple methods. This article presents the results of the extensive surveys and their comprehensive integrative interpretation, discussing Bassianae's ground plan and urban infrastructure. Starting with an overview of this Roman town's research history, we present the details of the triple prospection approach, followed by the processing, integrative analysis, and interpretation of the acquired data sets. Finally, this newly gained information is contrasted with a plan of Roman Bassianae compiled in 1935

The ‘Archpro Carnuntum’ Project – Integrated Archaeological Interpretation of Combined Prospection Data, Carnuntum (Austria) = Az „Archpro Carnuntum” projekt – kombinált kutatási adatok integrált régészeti értelmezése, Carnuntum (Ausztria)

The potential of large-scale, non-invasive prospection methods has been widely recognized in archaeology in recent years. Their outstanding possibilities for the exploration of urban centres have been realised early on and applied at selected sites. The ‘ArchPro Carnuntum’ project stands out for its extensive investigation of a Roman provincial capital by the combined application of a wide variety of survey methods (aerial archaeology, magnetometry, ground penetrating radar, extensive field survey) resulting in detailed information on the ancient infrastructure of the Roman metropolis. Within the project, it was not only possible to discover new settlement areas, but in some cases even to deduce their former purpose. As a result, the military administrative centre, newly built residential areas, and temporary military camps could be detected in the archaeological landscape of Carnuntum. This paper presents an overview of the results of this internationally unique prospection project. Az elmúlt évek során széles körben felismerték a régészet tudományterületén alkalmazható nagyszabású, nem invazív jellegű kutatási módszerekben rejlő potenciált. A módszer települési központok feltárásának területén alkalmazható lehetőségei már korán valósággá váltak, és alkalmazásra kerültek a kiválasztott helyszíneken. Az „ArchPro Carnuntum” projekt a római provinciális főváros átfogó vizsgálatával a legkülönfélébb felmérési módszerek (légi régészet, magnetometria, földradar, kiterjedt terepi felmérés) együttes alkalmazásával kiemelkedik ezek közül, és részletes információval szolgál a római város antik infrastruktúrájával kapcsolatban. A projekt során nem kizárólag új települési területek felfedezésére nyílt mód, hanem egyes esetekben következtetni lehetett a területek egykori funkciójára is. Mindezek eredményeként a carnuntumi régészeti területen kimutathatóvá vált a katonai igazgatási központ, valamint az új építésű lakónegyedek és az ideiglenes katonai táborhelyek is. Jelen tanulmány ezen nemzetközi szinten is egyedülálló kutatási projekt eredményeiről nyújt áttekintést

Quantifying HER-2 expression on circulating tumor cells by ACCEPT

Circulating tumor cells (CTCs) isolated from blood can be probed for the expression of treatment targets. Immunofluorescence is often used for both the enumeration of CTC and the determination of protein expression levels related to treatment targets. Accurate and reproducible assessment of such treatment target expression levels is essential for their use in the clinic. To enable this, an open source image analysis program named ACCEPT was developed in the EU-FP7 CTCTrap and CANCER-ID programs. Here its application is shown on a retrospective cohort of 132 metastatic breast cancer patients from which blood samples were processed by CellSearch (R) and stained for HER-2 expression as additional marker. Images were digitally stored and reviewers identified a total of 4084 CTCs. CTC's HER-2 expression was determined in the thumbnail images by ACCEPT. 150 of these images were selected and sent to six independent investigators to score the HER-2 expression with and without ACCEPT. Concordance rate of the operators' scoring results for HER2 on CTCs was 30% and could be increased using the ACCEPT tool to 51%. Automated assessment of HER-2 expression by ACCEPT on 4084 CTCs of 132 patients showed 8 (6.1%) patients with all CTCs expressing HER-2, 14 (10.6%) patients with no CTC expressing HER-2 and 110 (83.3%) patients with CTCs showing a varying HER-2 expression level. In total 1576 CTCs were determined HER-2 positive. We conclude that the use of image analysis enables a more reproducible quantification of treatment targets on CTCs and leads the way to fully automated and reproducible approaches

Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer

INTRODUCTION: Neoadjuvant systemic therapy (NST) is an established strategy to reduce tumor size in breast cancer patients prior to breast-conserving therapy. The effect of NST on tumor cell dissemination in these patients is not known. The aim of this study was to investigate the incidence of disseminated tumor cells (DTC), including apoptotic DTC, in breast cancer patients after NST, and to investigate the correlation of DTC status with therapy response. METHODS: Bone marrow aspiration was performed in 157 patients after NST. DTC were detected by immunocytochemistry using the A45–B/B3 anticytokeratin antibody. To detect apoptotic DTC the antibody M30 (Roche Diagnostics, Germany) was used, which detects a neo-epitope expressed only after caspase cleavage of cytokeratin 18 during early apoptosis. RESULTS: The incidence of DTC in breast cancer patients was 53% after completion of NST. Tumor dissemination was observed more frequently in patients with no change/progressive disease (69%) than in patients with partial remission or complete remission of the primary tumor (46%) (P < 0.05). Ten out of 24 patients with complete remission, however, were still bone marrow positive. Apoptotic DTC were present in 36 of 157 (23%) breast cancer patients. Apoptotic cells only were detected in 14% of the patients with partial remission or complete remission, but were detected in just 5% of the patients with stable disease. Apoptotic DTC were detectable in none of the patients with tumor progression. CONCLUSION: The pathological therapy response in breast cancer patients is reflected by the presence of apoptotic DTC. Patients with complete remission, however, may still have nonapoptotic DTC. These patients may also benefit from secondary adjuvant therapy