The role of sialoadenectomy and epýdermal growth factor (EGF) in skin development

In this study, the effect of epidermal growth factor (EGF) on skin development was investigated. A total of 24 adult female Spraque-Dawley rats were used in the study. The rats were divided into 3 equal groups as control, sialoadenectomy (SX) and sialoadenectomy+epidermal growth factor (SX+EGF). Sialoadenectomy was performed on the other groups except control. After a 21-day recovery period, subjects were made to mate. SX+EGF group rats were also given 12.5 ìg/day EGF for each animal orally in the 16, 17th, 18th and 19th days of pregnancy. After pregnancy, the offsprings obtained were grown until the 28th day. All 28-day-old offsprings in all groups were weighed and sacrificed. Skin samplesfrom interscapular region were examined under light and electron microscope. In light and electron microscopy, skin sections of SX group, atrophy in epiderm, hyperkeratosis, decrease in hair follicles and sebaceous glands, along with local thinning of basal membrane, hemidesmosome loss and necrotic cells were seen. In skin sections of SX+EGF group, the view was similar to controls. As a result, epidermal growth factor was concluded to have an important role in skin development

Immunohistochemical evaluation of iron accumulation in term placenta of preeclamptic patients

Preeclampsia is a disease which involves hypertension and multisystem, it effects approximately 2 to 8% of all pregnancies and is a significant cause of maternal and newborn mortality and morbidity. It develops in the placenta and its pathogenesis is associated with placental abnormalities. Classical immunohistochemical studies on placenta have shown that there is a linear increase in iron storage in the placenta in the first half of a normal pregnancy, however, these stocks are decreased in normal 3rd trimester placenta. Iron accumulation in term placentas of preeclamptic and normal pregnancies were evaluated in this study. Ferritin immunostaining was observed to be more intense in preeclamptic group than in the control group, especially in Hofbauer cells, subtrophoblastic areas of stem villous, perivasculer stroma and villous stroma. Statistical analysis of the data was performed using SPSS software. Mann Whitney U test was used in the analysis and P values below 0.05 were statistically significant. In this study, iron accumulations in normotensif and preeclamptic placentas werecompared.Key words: Preeclampsia, placenta, immunohistochemistry, iron accumulation

Towards trajectory anonymization: A generalization-based approach

Trajectory datasets are becoming,popular,due,to the massive,usage,of GPS and,location- based services. In this paper, we address privacy issues regarding the identification of individuals in static trajectory datasets. We first adopt the notion of k-anonymity,to trajectories and propose,a novel generalization-based approach,for anonymization,of trajectories. We further show,that releasing anonymized,trajectories may,still have,some,privacy,leaks. Therefore we propose,a randomization based,reconstruction,algorithm,for releasing anonymized,trajectory data and,also present how,the underlying,techniques,can be adapted,to other anonymity,standards. The experimental,results on real and,synthetic trajectory datasets show,the effectiveness of the proposed,techniques

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications

© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to inhibiting platelet aggregation, antithrombotic medications have shear-dependent effects, potentiating thrombus fragility and/or enhancing endogenous fibrinolysis. Such shear-dependent effects, potentiating the fragility of the growing thrombus and/or enhancing endogenous thrombolytic activity, likely contribute to the clinical effectiveness of such medications. It is not clear how much these effects relate to the measured inhibition of platelet aggregation in response to specific agonists. These effects are observable only with techniques that subject the growing thrombus to arterial flow and shear conditions. The effects of antithrombotic medications on thrombus stability and ways of assessing this are reviewed herein, and it is proposed that thrombus stability could become a new target for pharmacological intervention.Peer reviewedFinal Published versio

A Large Hadron Electron Collider at CERN

This document provides a brief overview of the recently published report on the design of the Large Hadron Electron Collider (LHeC), which comprises its physics programme, accelerator physics, technology and main detector concepts. The LHeC exploits and develops challenging, though principally existing, accelerator and detector technologies. This summary is complemented by brief illustrations of some of the highlights of the physics programme, which relies on a vastly extended kinematic range, luminosity and unprecedented precision in deep inelastic scattering. Illustrations are provided regarding high precision QCD, new physics (Higgs, SUSY) and electron-ion physics. The LHeC is designed to run synchronously with the LHC in the twenties and to achieve an integrated luminosity of O(100) fb$^{-1}$. It will become the cleanest high resolution microscope of mankind and will substantially extend as well as complement the investigation of the physics of the TeV energy scale, which has been enabled by the LHC

Status of the compactlight design study*

CompactLight (XLS) is an International Collaboration of 24 partners and 5 third parties, funded by the European Union through the Horizon 2020 Research and Innovation Programme. The main goal of the project, which started in January 2018 with a duration of 36 months, is the design of an hard X-ray FEL facility beyond today’s state of the art, using the latest concepts for bright electron photo-injectors, high-gradient accelerating structures, and innovative short-period undulators. The specifications of the facility and the parameters of the future FEL are driven by the demands of potential users and the associated science cases. In this paper we will give an overview on the ongoing activities and the major results achieved until now

Privacy-Preserving Release of Spatio-temporal Density

International audienceIn today’s digital society, increasing amounts of contextually rich spatio-temporal information are collected and used, e.g., for knowledge-based decision making, research purposes, optimizing operational phases of city management, planning infrastructure networks, or developing timetables for public transportation with an increasingly autonomous vehicle fleet. At the same time, however, publishing or sharing spatio-temporal data, even in aggregated form, is not always viable owing to the danger of violating individuals’ privacy, along with the related legal and ethical repercussions. In this chapter, we review some fundamental approaches for anonymizing and releasing spatio-temporal density, i.e., the number of individuals visiting a given set of locations as a function of time. These approaches follow different privacy models providing different privacy guarantees as well as accuracy of the released anonymized data. We demonstrate some sanitization (anonymization) techniques with provable privacy guarantees by releasing the spatio-temporal density of Paris, in France. We conclude that, in order to achieve meaningful accuracy, the sanitization process has to be carefully customized to the application and public characteristics of the spatio-temporal data