Reflecting on the Past

150 years of Augustana storieshttps://digitalcommons.augustana.edu/ahsreflecting/1000/thumbnail.jp

Reflecting on the Past

150 years of Augustana storieshttps://digitalcommons.augustana.edu/ahsreflecting/1000/thumbnail.jp

Integrating palliative care with intensive care for critically ill patients with lung cancer

With newer information indicating more favorable outcomes of intensive care therapy for lung cancer patients, intensivists increasingly are willing to initiate an aggressive trial of this therapy. Concerns remain, however, that the experience of the intensive care unit for patients with lung cancer and their families often may be distressing. Regardless of prognosis, all patients with critical illness should receive high-quality palliative care, including symptom control, communication about appropriate care goals, and support for both patient and family throughout the illness trajectory. In this article, we suggest strategies for integrating palliative care with intensive care for critically ill lung cancer patients. We address assessment and management of symptoms, knowledge and skill needed for effective communication, and interdisciplinary collaboration for patient and family support. We review the role of expert consultants in providing palliative care in the intensive care unit, while highlighting the responsibility of all critical care clinicians to address basic palliative care needs of patients and their families

Detailed Numerical Simulations on the Formation of Pillars around HII-regions

We study the structural evolution of turbulent molecular clouds under the influence of ionizing radiation emitted from a nearby massive star by performing a high resolution parameter study with the iVINE code. The temperature is taken to be 10K or 100K, the mean number density is either 100cm^3 or 300cm^3. Besides, the turbulence is varied between Mach 1.5 and Mach 12.5 and the main driving scale between 1pc and 8pc. We vary the ionizing flux by an order of magnitude. In our simulations the ionizing radiation enhances the initial turbulent density distribution and thus leads to the formation of pillar-like structures observed adjacent to HII regions in a natural way. Gravitational collapse occurs regularly at the tips of the structures. We find a clear correlation between the initial state of the turbulent cold cloud and the final morphology and physical properties of the structures formed. The most favorable regime for the formation of pillars is Mach 4-10. Structures and therefore stars only form if the initial density contrast between the high density unionized gas and the gas that is going to be ionized is lower than the temperature contrast between the hot and the cold gas. The density of the resulting pillars is determined by a pressure equilibrium between the hot and the cold gas. A thorough analysis of the simulations shows that the complex kinematical and geometrical structure of the formed elongated filaments reflects that of observed pillars to an impressive level of detail. In addition, we find that the observed line-of sight velocities allow for a distinct determination of different formation mechanisms. Comparing the current simulations to previous results and recent observations we conclude that e.g. the pillars of creation in M16 formed by the mechanism proposed here and not by the radiation driven implosion of pre-existing clumps.Comment: 15 pages, 12 figures, accepted for publication in Ap

Waveguide grating mirror in a fully suspended 10 meter Fabry-Perot cavity

We report on the first demonstration of a fully suspended 10m Fabry-Perot cavity incorporating a waveguide grating as the coupling mirror. The cavity was kept on resonance by reading out the length fluctuations via the Pound-Drever-Hall method and employing feedback to the laser frequency. From the achieved finesse of 790 the grating reflectivity was determined to exceed 99.2% at the laser wavelength of 1064\,nm, which is in good agreement with rigorous simulations. Our waveguide grating design was based on tantala and fused silica and included a ~20nm thin etch stop layer made of Al2O3 that allowed us to define the grating depth accurately during the fabrication process. Demonstrating stable operation of a waveguide grating featuring high reflectivity in a suspended low-noise cavity, our work paves the way for the potential application of waveguide gratings as mirrors in high-precision interferometry, for instance in future gravitational wave observatories

Low-Cost Sensors and Multitemporal Remote Sensing for Operational Turbidity Monitoring in an East African Wetland Environment

Many wetlands in East Africa are farmed and wetland reservoirs are used for irrigation, livestock, and fishing. Water quality and agriculture have a mutual influence on each other. Turbidity is a principal indicator of water quality and can be used for, otherwise, unmonitored water sources. Low-cost turbidity sensors improve in situ coverage and enable community engagement. The availability of high spatial resolution satellite images from the Sentinel-2 multispectral instrument and of bio-optical models, such as the Case 2 Regional CoastColor (C2RCC) processor, has fostered turbidity modeling. However, these models need local adjustment, and the quality of low-cost sensor measurements is debated. We tested the combination of both technologies to monitor turbidity in small wetland reservoirs in Kenya. We sampled ten reservoirs with low-cost sensors and a turbidimeter during five Sentinel-2 overpasses. Low-cost sensor calibration resulted in an R 2 of 0.71. The models using the C2RCC C2X-COMPLEX (C2XC) neural nets with turbidimeter measurements (R 2 = 0.83) and with low-cost measurements (R 2 = 0.62) performed better than the turbidimeter-based C2X model. The C2XC models showed similar patterns for a one-year time series, particularly around the turbidity limit set by Kenyan authorities. This shows that both the data from the commercial turbidimeter and the low-cost sensor setup, despite sensor uncertainties, could be used to validate the applicability of C2RCC in the study area, select the better-performing neural nets, and adapt the model to the study site. We conclude that combined monitoring with low-cost sensors and remote sensing can support wetland and water management while strengthening community-centered approaches.</p

Driving Turbulence and Triggering Star Formation by Ionizing Radiation

We present high resolution simulations on the impact of ionizing radiation of massive O-stars on the surrounding turbulent interstellar medium (ISM). The simulations are performed with the newly developed software iVINE which combines ionization with smoothed particle hydrodynamics (SPH) and gravitational forces. We show that radiation from hot stars penetrates the ISM, efficiently heats cold low density gas and amplifies over-densities seeded by the initial turbulence. The formation of observed pillar-like structures in star forming regions (e.g. in M16) can be explained by this scenario. At the tip of the pillars gravitational collapse can be induced, eventually leading to the formation of low mass stars. Detailed analysis of the evolution of the turbulent spectra shows that UV-radiation of O-stars indeed provides an excellent mechanism to sustain and even drive turbulence in the parental molecular cloud.Comment: 5 pages, 2 figures, accepted by ApJ Letter

Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to what extent these proteases are expressed in viral target cells in human tissues. Here, we show that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Similarly, coexpression of ACE2, the SARS-coronavirus receptor, and TMPRSS2 was frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Finally, activation of influenza virus was conserved between human, avian and porcine TMPRSS2, suggesting that this protease might activate influenza virus in reservoir-, intermediate- and human hosts. In sum, our results show that TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host

Fibroblastic Reticular Cells From Lymph Nodes Attenuate T Cell Expansion by Producing Nitric Oxide

Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that FRC lines and ex vivo FRC inhibit T cell proliferation but not differentiation. FRC share this feature with fibroblasts from non-lymphoid tissues as well as mesenchymal stromal cells. We identified FRC as strong source of nitric oxide (NO) thereby directly dampening T cell expansion as well as reducing the T cell priming capacity of DC. The expression of inducible nitric oxide synthase (iNOS) was up-regulated in a subset of FRC by both DC-signals as well as interferon-γ produced by primed CD8+ T cells. Importantly, iNOS expression was induced during viral infection in vivo in both LN FRC and DC. As a consequence, the primary T cell response was found to be exaggerated in Inos−/− mice. Our findings highlight that in addition to their established positive roles in T cell responses FRC and DC cooperate in a negative feedback loop to attenuate T cell expansion during acute inflammation

Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo

Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Campinas, UNICAMP, Dept Parasitol, Inst Biol, BR-13083970 Campinas, SP, BrazilUniv Estadual Campinas, UNICAMP, Dept Microbiol & Imunol, Inst Biol, BR-13083970 Campinas, SP, BrazilUniversidade Federal de São Paulo, UNIFESP, Dept Bioquim, BR-04044020 São Paulo, BrazilCEPEM, IPEPATRO, BR-78900970 Porto Velho, RO, BrazilUniv São Paulo, Dept Parasitol, ICB2, São Paulo, BrazilUniv Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP, BrazilUniv Estadual Campinas, Lab Quim Biol, Inst Quim, BR-13083970 Campinas, SP, BrazilUniversidade Federal de São Paulo, UNIFESP, Dept Bioquim, BR-04044020 São Paulo, BrazilFAPESP: 2004/00638-6CNPq: 470587/2006-7Web of Scienc