Fragmentation and Evolution of Molecular Clouds. I: Algorithm and First Results

We present a series of simulations of the fragmentation of a molecular cloud, leading to the formation of a cluster of protostellar cores. The purpose of these simulations is to address a specific numerical problem called artificial fragmentation, that plagues SPH simulations of cloud fragmentation. We argue that this is a serious problem that needs to be addressed, and that the only reasonable and practical way to address it is to use a relatively new technique called particle splitting. Our largest simulation has an effective resolution of 256^3 particles (much higher than most previous SPH simulations of cloud fragmentation) and results in the formation of a dense cluster containing ~3000 protostellar cores. It is the first simulation of this kind to properly resolve the Jeans mass throughout the entire system, at all times, thus preventing artificial fragmentation.Comment: 47 pages, 15 figures (2 grayscale, one color), ApJ Suppl, in pres

CO in Protostars (COPS): HerschelHerschel-SPIRE Spectroscopy of Embedded Protostars

We present full spectral scans from 200-670$\mu$m of 26 Class 0+I protostellar sources, obtained with $Herschel$-SPIRE, as part of the "COPS-SPIRE" Open Time program, complementary to the DIGIT and WISH Key programs. Based on our nearly continuous, line-free spectra from 200-670 $\mu$m, the calculated bolometric luminosities ($L_{\rm bol}$) increase by 50% on average, and the bolometric temperatures ($T_{\rm bol}$) decrease by 10% on average, in comparison with the measurements without Herschel. Fifteen protostars have the same Class using $T_{\rm bol}$ and $L_{\rm bol}$/$L_{\rm submm}$. We identify rotational transitions of CO lines from J=4-3 to J=13-12, along with emission lines of $^{13}$CO, HCO$^+$, H$_{2}$O, and [CI]. The ratios of $^{12}$CO to $^{13}$CO indicate that $^{12}$CO emission remains optically thick for $J_{\rm up}$ < 13. We fit up to four components of temperature from the rotational diagram with flexible break points to separate the components. The distribution of rotational temperatures shows a primary population around 100 K with a secondary population at $\sim$350 K. We quantify the correlations of each line pair found in our dataset, and find the strength of correlation of CO lines decreases as the difference between $J$-level between two CO lines increases. The multiple origins of CO emission previously revealed by velocity-resolved profiles are consistent with this smooth distribution if each physical component contributes to a wide range of CO lines with significant overlap in the CO ladder. We investigate the spatial extent of CO emission and find that the morphology is more centrally peaked and less bipolar at high-$J$ lines. We find the CO emission observed with SPIRE related to outflows, which consists two components, the entrained gas and shocked gas, as revealed by our rotational diagram analysis as well as the studies with velocity-resolved CO emission.Comment: 50 pages, 18 figures, accepted to ApJS. Revised for Table 6 and Figure

Two species of Hoploscaphites.

72 pages : illustrations (some color), map ; 26 cm.Two species of scaphitid ammonites (Ammonoidea: Ancyloceratina) from the Upper Cretaceous (lower Maastrichtian) of the Western Interior of North America are described. Hoploscaphites macer, n. sp., is medium size, with coarse ribs on the phragmocone, which become finer on the body chamber, and closely spaced ventrolateral tubercles. It occurs in the upper part of the Baculites baculus Zone and lower part of the overlying B. grandis Zone in the Pierre Shale in Montana, Wyoming, and Colorado, and in the Bearpaw Shale in Montana. Hoploscaphites criptonodosus (Riccardi, 1983) is larger and more coarsely ornamented, including one or two rows of lateral tubercles on the flanks of the phragmocone. It occurs in the upper part of the Baculites baculus Zone and overlying B. grandis Zone in the Pierre Shale in Montana, Wyoming, Colorado, and possibly South Dakota, and in the Bearpaw Shale in Montana and Saskatchewan, Canada. Both species form part of an evolving lineage of Hoploscaphites that first appears in the Western Interior of North America in the middle Campanian

Tracing the Mass during Low-Mass Star Formation, IV: Observations and Modeling of the Submillimeter Continuum Emission from Class I Protostars

We present results from the observations and modeling of seventeen Class I cores with the Submillimetre Common Users Bolometer Array (SCUBA) on the James Clerk Maxwell Telescope (JCMT). By modeling the transfer of radiation through the envelope for nine cores, we find, for a power law distribution n(r)=n_f(r/r_f)^-p, the average and standard deviation p=1.6 +/- 0.4 and a median of p=1.8. However, the inclusion of a disk or other point-like component can cause the derived p to be shallower by as much as 0.5. In addition, we test the Shu collapse model for our sources and discuss the application of simpler analyses that derive a density power law distribution directly from the slope of the intensity radial profile. The total mass of the envelope in our sample has a range from 0.04 to 5.0 M_sun, but these masses disagree with the virial masses derived from molecular line observations. Finally, we discuss the nature of these sources in light of various evolutionary indicators and find that T_bol and L_obs/L_smm are often inconsistent in distinguishing Class 0 from Class I cores.Comment: Accepted to ApJS. 50 pages with 27 figures and 12 tables. High-resolution figures at http://peggysue.as.utexas.edu/cyoung

Chemistry and Dynamics in Pre-Protostellar Cores

We have compared molecular line emission to dust continuum emission and modeled molecular lines using Monte Carlo simulations in order to study the depletion of molecules and the ionization fraction in three preprotostellar cores, L1512, L1544, and L1689B. L1512 is much less dense than L1544 and L1689B, which have similar density structures. L1689B has a different environment from those of L1512 and L1544. We used density and temperature profiles, calculated by modeling dust continuum emission in the submillimeter, for modeling molecular line profiles. In addition, we have used molecular line profiles and maps observed in several different molecules toward the three cores. We find a considerable diversity in chemical state among the three cores. The molecules include those sensitive to different timescales of chemical evolution such as CCS, the isotopes of CO and HCO+, DCO+, and N2H+. The CO molecule is significantly depleted in L1512 and L1544, but not in L1689B. CCS may be in the second enhancement of its abundance in L1512 and L1544 because of the significant depletion of CO molecules. N2H+ might already start to be depleted in L1512, but it traces very well the distribution of dust emission in L1544. On the other hand, L1689B may be so young that N2H+ has not reached its maximum yet. The ionization fraction has been calculated using H13CO+ and DCO+. This study suggests that chemical evolution depends on the absolute timescale during which a core stays in a given environment as well as its density structure.Comment: 33 pages, 12 figures, accepted to Ap

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenetic silencing, and outline a mechanism by which common risk variants could effect functional changes that increase disease risk: functional assays suggest that HNF1B is a pro-differentiation factor that suppresses epithelial-to-mesenchymal transition (EMT) in unmethylated, healthy tissues. This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC. Epigenetic inactivation of HNF1B in ovarian cancer also associates with known risk SNPs, with a similar impact on EMT. This represents one of the first comprehensive studies into the pleiotropic role of a GWAS-associated transcription factor across distinct cancer types, and is the first to describe a conserved role for a multi-cancer genetic risk factor

The Bolocam Galactic Plane Survey V: HCO+ and N2H+ Spectroscopy of 1.1 mm Dust Continuum Sources

We present the results of observations of 1882 sources in the Bolocam Galactic Plane Survey (BGPS) at 1.1 mm with the 10m Heinrich Hertz Telescope simultaneously in HCO+ J=3-2 and N2H+ J=3-2. We detect 77% of these sources in HCO^+ and 51% in N2H+ at greater than 3$\sigma$. We find a strong correlation between the integrated intensity of both dense gas tracers and the 1.1 mm dust emission of BGPS sources. We determine kinematic distances for 529 sources (440 in the first quadrant breaking the distance ambiguity and 89 in the second quadrant) We derive the size, mass, and average density for this subset of clumps. The median size of BGPS clumps is 0.75 pc with a median mass of 330 M$_{\odot}$ (assuming T_{Dust}=20 K). The median HCO+ linewidth is 2.9 km s$^{-1}$ indicating that BGPS clumps are dominated by supersonic turbulence or unresolved kinematic motions. We find no evidence for a size-linewidth relationship for BGPS clumps. We analyze the effects of the assumed dust temperature on the derived clump properties with a Monte Carlo simulation and we find that changing the temperature distribution will change the median source properties (mass, volume-averaged number density, surface density) by factors of a few. The observed differential mass distribution has a power-law slope that is intermediate between that observed for diffuse CO clouds and the stellar IMF. BGPS clumps represent a wide range of objects (from dense cores to more diffuse clumps) and are typically characterized by larger sizes and lower densities than previously published surveys of high-mass star-forming regions. This collection of objects is a less-biased sample of star-forming regions in the Milky Way that likely span a wide range of evolutionary states.Comment: 48 pages, 25 figures, Accepted for publicatio

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation

Happiness Through Vacationing: Just a Temporary Boost or Long-Term Benefits?

Does vacationing add to our happiness in the long run? This question was addressed in a study of 3,650 Dutch citizens who reported their leisure travel every 3 months during 2 years and rated their happiness at the end of each year. Participants who had been on vacation appeared to be marginally happier, in terms of hedonic level of affect, than those who had not. This difference in Affect balance between vacationers and non-vacationers is probably due to a very minor causal effect of vacationing on hedonic level of affect. Possibly, vacationing is positively reminisced and these memories allow for the prevalence of more positive affect in people's lives. Happiness did not predict vacationing. The effect of holiday trips on vacationers' happiness is mostly short-lived; among vacationers, happiness was unrelated to the number of trips and days spent on vacation. A separate analysis of vacationers, who value vacationing most, yielded the same results. Implications for future research are discussed