Metamorfosis en Augusta Treverorum

Trier Stadtbibliothek owns five unpublished Ovidian fragments, one from Amores and four from Metamorphoses. This paper offers a first-time collation of the latter.No disponible

Seguimiento del Grado en Matemáticas

Tal y como se ha desarrollado en años anteriores, el objetivo principal de esta red ha sido procurar la mejora en la coordinación y el seguimiento de los cursos correspondientes al Grado en Matemáticas de la Facultad de Ciencias de la Universidad de Alicante, que en el presente curso académico ha recibido la renovación de la acreditación y se engloba dentro del proceso general del seguimiento de todos los títulos de la Facultad de Ciencias. La red está coordinada por la coordinadora del Grado en Matemáticas y formada por los coordinadores de cada uno de los semestres. Se pretende evidenciar los progresos del título en el desarrollo del Sistema de Garantía Interno de Calidad (SGIC), con el fin de detectar las posibles deficiencias en el proceso de implantación del grado y contribuir a la propuesta de acciones para mejorar su diseño y desarrollo

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-based treatment regimens, often because of drug resistance-associated substitutions (RAS). The aim of this study was to characterize the resistance profile of a large cohort of patients failing DAA-based treatments, and investigate the relationship between HCV subtype and failure, as an aid to optimizing management of these patients. A new, standardized HCV-RAS testing protocol based on deep sequencing was designed and applied to 220 previously subtyped samples from patients failing DAA treatment, collected in 39 Spanish hospitals. The majority had received DAA-based interferon (IFN) a-free regimens; 79% had failed sofosbuvir-containing therapy. Genomic regions encoding the nonstructural protein (NS) 3, NS5A, and NS5B (DAA target regions) were analyzed using subtype-specific primers. Viral subtype distribution was as follows: genotype (G) 1, 62.7%; G3a, 21.4%; G4d, 12.3%; G2, 1.8%; and mixed infections 1.8%. Overall, 88.6% of patients carried at least 1 RAS, and 19% carried RAS at frequencies below 20% in the mutant spectrum. There were no differences in RAS selection between treatments with and without ribavirin. Regardless of the treatment received, each HCV subtype showed specific types of RAS. Of note, no RAS were detected in the target proteins of 18.6% of patients failing treatment, and 30.4% of patients had RAS in proteins that were not targets of the inhibitors they received. HCV patients failing DAA therapy showed a high diversity of RAS. Ribavirin use did not influence the type or number of RAS at failure. The subtype-specific pattern of RAS emergence underscores the importance of accurate HCV subtyping. The frequency of “extra-target” RAS suggests the need for RAS screening in all three DAA target regions

Inducción transcripcional del gen de la sintasa endotelial del óxido nítrico y formación de peroxinítrito en el endotelio vascular en respuesta a Ciclosporina A

Tesis doctoral inédita leída en la Universidad Autonoma de Madrid, Facultad de Medicina, Departamento de Medicina, 18 de Diciembre de 200

Seguimiento del Grado en Matemáticas: Curso 16-17

El objetivo principal de esta red es procurar la mejora en la coordinación y el seguimiento de los cursos correspondientes al Grado en Matemáticas de la Facultad de Ciencias de la Universidad de Alicante, que se engloba dentro del proceso general del seguimiento de todos los títulos de la Facultad de Ciencias. Para lograr este objetivo se han planteado varias tareas entre las que destacamos: el estudio de las recomendaciones recibidas en el informe final de reacreditación del título emitido por la AVAP (Agencia Valenciana de Evaluación y Prospectiva) tras la renovación de la acreditación del Grado durante el curso anterior con una valoración global FAVORABLE, estudio de la evolución de los resultados de las convocatorias ordinarias, encuestas a todos los alumnos sobre el funcionamiento de cada asignatura, encuesta a alumnos de 3º y 4º curso sobre Másters y, por último, estudio comparativo de tasas de abandono con los grados de matemáticas del resto de universidades españolas. La red está dirigida por la coordinadora del Grado en Matemáticas y formada por los coordinadores de cada uno de los semestres

Na+ controls hypoxic signalling by the mitochondrial respiratory chain

All metazoans depend on O2 delivery and consumption by the mitochondrial oxidative phosphorylation (OXPHOS) system to produce energy. A decrease in O2 availability (hypoxia) leads to profound metabolic rewiring. In addition, OXPHOS uses O2 to produce reactive oxygen species (ROS) that can drive cell adaptations through redox signalling, but also trigger cell damage1–4, and both phenomena occur in hypoxia4–8. However, the precise mechanism by which acute hypoxia triggers mitochondrial ROS production is still unknown. Ca2+ is one of the best known examples of an ion acting as a second messenger9, yet the role ascribed to Na+ is to serve as a mere mediator of membrane potential and collaborating in ion transport10. Here we show that Na+ acts as a second messenger regulating OXPHOS function and ROS production by modulating fluidity of the inner mitochondrial membrane (IMM). We found that a conformational shift in mitochondrial complex I during acute hypoxia11 drives the acidification of the matrix and solubilization of calcium phosphate precipitates. The concomitant increase in matrix free-Ca2+ activates the mitochondrial Na+/Ca2+ exchanger (NCLX), which imports Na+ into the matrix. Na+ interacts with phospholipids reducing IMM fluidity and mobility of free ubiquinone between complex II and complex III, but not inside supercomplexes. As a consequence, superoxide is produced at complex III, generating a redox signal. Inhibition of mitochondrial Na+ import through NCLX is sufficient to block this pathway, preventing adaptation to hypoxia. These results reveal that Na+ import into the mitochondrial matrix controls OXPHOS function and redox signalling through an unexpected interaction with phospholipids, with profound consequences in cellular metabolism