Development of High Granulated Straw Chambers of Large Sizes

We have developed the baseline design for the straw drift tube tracking detectors for high rate environment application. The low-mass inner straw elements and the technology of the multianode straws assembly was devised and checked. The prototype chamber was constructed and studied the granularity of similar chambers can be reduced to one cm2. Submitted to Physics of Elementary Particles and Atomic Nuclei, LettersComment: 6 pages, 10 figure

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection

Abstract: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis induced by infection with Neisseria gonorrhoeae (Ngo). While Bim and Bmf were associated with the cytoskeleton of healthy cells, they both were released upon Ngo infection. Loss of Bim and Bmf from the cytoskeleton fraction required the activation of Jun-N-terminal kinase-1 (JNK-1), which in turn depended on Rac-1. Depletion and inhibition of Rac-1, JNK-1, Bim, or Bmf prevented the activation of Bak and Bax and the subsequent activation of caspases. Apoptosis could be reconstituted in Bim-depleted and Bmf-depleted cells by additional silencing of antiapoptotic Mcl-1 and Bcl-XL, respectively. Our data indicate a synergistic role for both cytoskeletal-associated BH3-only proteins, Bim, and Bmf, in an apoptotic pathway leading to the clearance of Ngo-infected cells. Author Summary: A variety of physiological death signals, as well as pathological insults, trigger apoptosis, a genetically programmed form of cell death. Pathogens often induce host cell apoptosis to establish a successful infection. Neisseria gonorrhoeae (Ngo), the etiological agent of the sexually transmitted disease gonorrhoea, is a highly adapted obligate human-specific pathogen and has been shown to induce apoptosis in infected cells. Here we unveil the molecular mechanisms leading to apoptosis of infected cells. We show that Ngo-mediated apoptosis requires a special subset of proapoptotic proteins from the group of BH3-only proteins. BH3-only proteins act as stress sensors to translate toxic environmental signals to the initiation of apoptosis. In a siRNA-based miniscreen, we found Bim and Bmf, BH3-only proteins associated with the cytoskeleton, necessary to induce host cell apoptosis upon infection. Bim and Bmf inactivated different inhibitors of apoptosis and thereby induced cell death in response to infection. Our data unveil a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic cell death

Contribution of the nucleon-hyperon reaction channels to K−^- production in proton-nucleus collisions

The cross sections for producing K$^-$ mesons in nucleon-hyperon elementary processes are estimated assuming one-pion exchange and using the experimentally known pion-hyperon cross sections. The results are implemented in a transport model which is applied to calculation of proton-nucleus collisions. In significant difference to earlier estimates for heavy-ion collisions the inclusion of the nucleon-hyperon cross section roughly doubles the K$^-$ production in near-threshold proton-nucleus collisions

Postdeployment Battlemind training for the U.K. armed forces: a cluster randomized controlled trial

OBJECTIVE: Combat exposure can increase the risk of subsequent psychological ill-health in armed forces (AF) personnel. A U.S. postdeployment psycho-educational intervention, Battlemind, showed a beneficial effect on mental health in U.S. military personnel exposed to high combat levels. We evaluated the effectiveness of an anglicized version of postdeployment Battlemind. METHOD: Battlemind was adapted for the United Kingdom. The main amendments were to sections about carrying weapons, driving, and alcohol misuse. The anglicized Battlemind was compared with the U.K. standard postdeployment brief in a cluster randomized controlled trial. At baseline, 2,443 U.K. AF personnel returning from Afghanistan via Cyprus completed questionnaires about their combat experiences and mental health. Of these, 1,616 (66%) completed 6-month follow-up questionnaires. We used the Posttraumatic Stress Disorder Checklist (PCL-C) to measure probable posttraumatic stress disorder and the General Health Questionnaire (GHQ-12) to measure common mental disorders. Secondary outcomes included alcohol misuse, assessed with the Alcohol Use Disorders Identification Test (AUDIT), and binge drinking. Mixed-effects models were used to account for possible cluster effects. RESULTS: We did not find a difference in mental health or overall AUDIT score. Those who received Battlemind versus the standard brief were less likely to report binge drinking, although the effect size was small (adjusted odds ratio = 0.73, 95% CI [0.58, 0.92]). CONCLUSIONS: The anglicized Battlemind did not improve mental health but had a modest impact on the reporting of binge drinking. Alcohol misuse is problematic in military populations; therefore, an intervention that reduces binge drinking may be helpful

The HADES Tracking System

The tracking system of the dielectron spectrometer HADES at GSI Darmstadt is formed out of 24 low-mass, trapezoidal multi-layer drift chambers providing in total about 30 square meter of active area. Low multiple scattering in the in total four planes of drift chambers before and after the magnetic field is ensured by using helium-based gas mixtures and aluminum cathode and field wires. First in-beam performance results are contrasted with expectations from simulations. Emphasis is placed on the energy loss information, exploring its relevance regarding track recognition.Comment: 6 pages, 4 figures, presented at the 10th Vienna Conference on Instrumentation, Vienna, February 2004, to be published in NIM A (special issue

Forward Beam Monitor for the KATRIN experiment

The KArlsruhe TRItium Neutrino (KATRIN) experiment aims to measure the neutrino mass with a sensitivity of 0.2 eV (90 % CL). This will be achieved by a precision measurement of the endpoint region of the β-electron spectrum of tritium decay. The β-electrons are produced in the Windowless Gaseous Tritium Source (WGTS) and guided magnetically through the beamline. In order to accurately extract the neutrino mass the source activity is required to be stable and known to a high precision. The WGTS therefore undergoes constant extensive monitoring from several measurement systems. The Forward Beam Monitor (FBM) is one such monitoring system. The FBM system comprises a complex mechanical setup capable of inserting a detector board into the KATRIN beamline with a positioning precision of better than 0.3 mm. The electron flux density at that position is on the order of 10$^6$ s$^{-1}$ mm$^{-2}$. The detector board contains two silicon detector chips of p-i-n diode type which can measure the β-electron flux from the source with a precision of 0.1 % within 60 s with an energy resolution of FWHM = 2 keV. The unique challenge in developing the FBM arises from its designated operating environment inside the Cryogenic Pumping Section which is a potentially tritium contaminated ultra-high vacuum chamber at cryogenic temperatures in the presence of a 1 T strong magnetic field. Each of these parameters do strongly limit the choice of possible materials which e.g. caused difficulties in detector noise reduction, heat dissipation and lubrication. In order to completely remove the FBM from the beam tube a 2 m long traveling distance into the beamline is needed demanding a robust as well as highly precise moving mechanism

Single-Pion Production in pp Collisions at 0.95 GeV/c (II)

The single-pion production reactions $pp\to d\pi^+$, $pp\to np\pi^+$ and $pp\to pp\pi^0$ were measured at a beam momentum of 0.95 GeV/c ($T_p \approx$ 400 MeV) using the short version of the COSY-TOF spectrometer. The central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements from other detector parts. Thus all pion production channels were recorded with 1-4 overconstraints. Main emphasis is put on the presentation and discussion of the $np\pi^+$ channel, since the results on the other channels have already been published previously. The total and differential cross sections obtained are compared to theoretical calculations. In contrast to the $pp\pi^0$ channel we find in the $np\pi^+$ channel a strong influence of the $\Delta$ excitation already at this energy close to threshold. In particular we find a $(3 cos^2\Theta + 1)$ dependence in the pion angular distribution, typical for a pure s-channel $\Delta$ excitation and identical to that observed in the $d\pi^+$ channel. Since the latter is understood by a s-channel resonance in the $^1D_2$ $pn$ partial wave, we discuss an analogous scenario for the $pn\pi^+$ channel

Single \pi^- production in np collisions for excess energies up to 90 MeV

The quasifree reaction np\to pp\pim was studied in a kinematically complete experiment by bombarding a liquid hydrogen target with a deuteron beam of momentum 1.85 GeV/c and analyzing the data along the lines of the spectator model. In addition to the three charged ejectiles the spectator proton was also detected in the large-acceptance time-of-flight spectrometer COSY-TOF. It was identified by its momentum and flight direction thus yielding access to the Fermi motion of the bound neutron and to the effective neutron 4-momentum vector $\mathbb{P}_n$ which differed from event to event. A range of almost 90 MeV excess energy above threshold was covered. Energy dependent angular distributions, invariant mass spectra as well as fully covered Dalitz plots were deduced. Sizeable $pp$ FSI effects were found as were contributions of $p$ and $d$ partial waves. The behavior of the elementary cross section $\sigma_{01}$ close to threshold is discussed in view of new cross section data. In comparison with existing literature data the results provide a sensitive test of the spectator model.Comment: 21 pages, 9 figures, 4 tables, submitted to EPJ

Measurement of the Eta Production in Proton Proton Collisions with the COSY Time of Flight Spectrometer

The reaction pp -> pp eta was measured at excess energies of 15 and 41 MeV at an external target of the Juelich Cooler Synchrotron COSY with the Time of Flight Spectrometer. About 25000 events were measured for the excess energy of 15 MeV and about 8000 for 41 MeV. Both protons of the process pp eta were detected with an acceptance of nearly 100% and the eta was reconstructed by the missing mass technique. For both excess energies the angular distributions are found to be nearly isotropic. In the invariant mass distributions strong deviations from the pure phase space distributions are seen.Comment: 15 pages, 14 figures, 4 table

Production of ω\omega mesons in proton-proton collisions

The cross section for the production of $\omega$ mesons in proton-proton collisions has been measured in a previously unexplored region of incident energies. Cross sections were extracted at 92 MeV and 173 MeV excess energy, respectively. The angular distribution of the $\omega$ at $\epsilon$=173 MeV is strongly anisotropic, demonstrating the importance of partial waves beyond pure s-wave production at this energy.Comment: 12 pages, 4 figures submitted to Physics Letters B v2: figure 1 added, discussion detailing the data analysis, figure 3 (fig. 2 in v1) modified in line styles and systematic errors displayed on dat