137 research outputs found
Groundwater redox conditions and conductivity in a contaminant plume from geoelectrical investigations
International audienceAccurate mapping of the electrical conductivity and of the redox potential of the groundwater is important in delineating the shape of a contaminant plume. A map of redox potential in an aquifer is indicative of biodegradation of organic matter and of concentrations of redox-active components; a map of electrical conductivity provides information on the mineralisation of the groundwater. Both maps can be used to optimise the position of pumping wells for remediation. The self-potential method (SP) and electrical resistivity tomography (ERT) have been applied to the contaminant plume associated with the Entressen landfill in south-east France. The self-potential depends on groundwater flow (electrokinetic contribution) and redox conditions ("electro-redox" contribution). Using the variation of the piezometric head in the aquifer, the electrokinetic contribution is removed from the SP signals. A good linear correlation (R2=0.85) is obtained between the residual SP data and the redox potential values measured in monitoring wells. This relationship is used to draw a redox potential map of the overall contaminated site. The electrical conductivity of the subsoil is obtained from 3D-ERT analysis. A good linear correlation (R2=0.91) is observed between the electrical conductivity of the aquifer determined from the 3D-ERT image and the conductivity of the groundwater measured in boreholes. This indicates that the formation factor is nearly homogeneous in the shallow aquifer at the scale of the ERT. From this correlation, a map of the pore water conductivity of the aquifer is obtained. Keywords: self-potential, redox potential, electrical resistivity tomography, fluid conductivity, contaminant plum
Natural Nuclear Reactor Oklo and Variation of Fundamental Constants Part 1: Computation of Neutronics of Fresh Core
Using modern methods of reactor physics we have performed full-scale
calculations of the natural reactor Oklo. For reliability we have used recent
version of two Monte Carlo codes: Russian code MCU REA and world wide known
code MCNP (USA). Both codes produce similar results. We have constructed a
computer model of the reactor Oklo zone RZ2 which takes into account all
details of design and composition. The calculations were performed for three
fresh cores with different uranium contents. Multiplication factors,
reactivities and neutron fluxes were calculated. We have estimated also the
temperature and void effects for the fresh core. As would be expected, we have
found for the fresh core a significant difference between reactor and Maxwell
spectra, which was used before for averaging cross sections in the Oklo
reactor. The averaged cross section of Sm-149 and its dependence on the shift
of resonance position (due to variation of fundamental constants) are
significantly different from previous results.
Contrary to results of some previous papers we find no evidence for the
change of the fine structure constant in the past and obtain new, most accurate
limits on its variation with time:
-4 10^{-17}year^{-1} < d alpha/dt/alpha < 3 10^{-17} year^{-1}
A further improvement in the accuracy of the limits can be achieved by taking
account of the core burnup. These calculations are in progress.Comment: 25 pages, 14 figures, 12 tables, minor corrections, typos correcte
Impact of solid waste disposal on nutrient dynamics in a sandy catchment
Groundwaters impacted by mature landfill leachate are generally enriched in ammonium. In order to assess the dynamics of ammonium exchanges between leachates and the water system inside a sandy permeable catchment we measured ammonium, nitrate and chloride concentrations in the stream and in sediment pore waters of the streambed of a landfill impacted aquifer. Geophysical investigation methods complemented the biogeochemical survey. The studied zone is a 23 kmÂČ catchment located in a coastal lagoon area sensitive to eutrophication risk. Ammonium concentrations in the river were up to 800 ”mol lâ1 during low water period in summer. Three surveys of the river chemistry showed a regular increase in ammonium, nitrate and chloride concentrations along a 1 km section of the watercourse, downstream the landfill, implying that the leachate plume exfiltrates along this section. Sediment cores collected within this section showed all an increase in ammonium concentrations with depth in pore waters as a consequence of the landfill leachate dispersion, as attested by a simultaneous increase in chloride concentrations. Nitrate enrichment in the river water was due to nitrification of ammonium at the interface between groundwater and streamwater. The apparent nitrification rate obtained was within values reported for turbid estuaries, although the river contained very little suspended particulate matter. Actually, pore water chemistry suggests that nitrification occurred for the most part in subsurface permeable sediments, rather than in stream water. The overall topographic, hydrological, geochemical, and geoelectrical data set permit to estimate the extension of the chloride and ammonium plume. The estimation of the apparent ammonium plume velocity is 23 m yearâ1 whereas the chloride plume velocity should be 50 m yearâ1. The river is the outlet of the impacted groundwaters. Considering that the input of ammonium from the landfill is balanced by the present day output via the river, the residence time of ammonium in the aquifer is between 7 and 18 years
Proton-proton bremsstrahlung below and above pion-threshold: the influence of the -isobar
The proton-proton bremsstrahlung is investigated within a coupled-channel
model with the degree of freedom. The model is consistent with the
scattering up to 1 GeV and the vertex determined in the
study of pion photoproduction reactions. It is found that the
excitation can significantly improve the agreements with the at MeV. Predictions at and MeV are
presented for future experimental tests.Comment: 26 pages Revtex, 12 figures are available from the authors upon
request ([email protected]
A 1-D modelling of streaming potential dependence on water content during drainage experiment in sand
The understanding of electrokinetics for unsaturated conditions is crucial
for numerous of geophysical data interpretation. Nevertheless, the behaviour of
the streaming potential coefficient C as a function of the water saturation Sw
is still discussed. We propose here to model both the Richards' equation for
hydrodynamics and the Poisson's equation for electrical potential for
unsaturated conditions using 1-D finite element method. The equations are first
presented and the numerical scheme is then detailed for the Poisson's equation.
Then, computed streaming potentials (SPs) are compared to recently published SP
measurements carried out during drainage experiment in a sand column. We show
that the apparent measurement of DV / DP for the dipoles can provide the SP
coefficient in these conditions. Two tests have been performed using existing
models for the SP coefficient and a third one using a new relation. The results
show that existing models of unsaturated SP coefficients C(Sw) provide poor
results in terms of SP magnitude and behaviour. We demonstrate that the
unsaturated SP coefficient can be until one order of magnitude larger than
Csat, its value at saturation. We finally prove that the SP coefficient follows
a non-monotonous behaviour with respect to water saturation. Key words:
Electrical properties; Electromagnetic theory; Hydrogeophysics; Hydrology;
Permeability and porosity; electrokinetic; streaming potential; self-potential;
water content; water saturation; unsaturated condition; finite element modelin
Dielectron Cross Section Measurements in Nucleus-Nucleus Reactions at 1.0 A GeV
We present measured dielectron production cross sections for Ca+Ca, C+C,
He+Ca, and d+Ca reactions at 1.0 A GeV. Statistical uncertainties and
systematic effects are smaller than in previous DLS nucleus-nucleus data. For
pair mass < 0.35 GeV/c2 : 1) the Ca+Ca cross section is larger than the
previous DLS measurement and current model results, 2) the mass spectra suggest
large contributions from pi0 and eta Dalitz decays, and 3) dsigma/dM is
proportional to ApAt. For M > 0.5 GeV/c2 the Ca+Ca to C+C cross section ratio
is significantly larger than the ratio of ApAt values.Comment: Submitted to Physical Review Letters. Further analysis information
will be posted on our web pages -- http://macdls.lbl.gov Figure 1 has been
redrawn to make more legible. Text modified to support redrawn figur
Probing the Rho Spectral Function in Hot and Dense Nuclear Matter by Dileptons
We present a dynamical study of and production in
proton-nucleus and nucleus-nucleus collisions at CERN-SPS energies on the basis
of the covariant transport approach HSD employing a momentum-dependent
-meson spectral function that includes the pion modifications in the
nuclear medium as well as the polarization of the -meson due to resonant
scattering. We find that the experimental data from the CERES and
HELIOS-3 Collaborations can be described equally well as within the dropping
-mass scenario. Whereas corresponding dilepton -spectra are found to
be very similar, the inclusive dilepton yield in the invariant mass range GeV should allow to disentangle the two scenarios
experimentally.Comment: 13 pages RevTeX slightly revised, 6 eps-figure
Enhancement of low-mass dileptons in heavy-ion collisions
Using a relativistic transport model for the expansion stage of S+Au
collisions at 200 GeV/nucleon, we show that the recently observed enhancement
of low-mass dileptons by the CERES collaboration can be explained by the
decrease of vector meson masses in hot and dense hadronic matter.Comment: 12 pages, RevTeX, 3 figures available from [email protected]
Inclusive Dielectron Cross Sections in p+p and p+d Interactions at Beam Energies from 1.04 to 4.88 GeV
Measurements of dielectron production in p+p and p+d collisions with beam
kinetic energies from 1.04 to 4.88 GeV are presented. The differential cross
section is presented as a function of invariant pair mass, transverse momentum,
and rapidity. The shapes of the mass spectra and their evolution with beam
energy provide information about the relative importance of the various
dielectron production mechanisms in this energy regime. The p+d to p+p ratio of
the dielectron yield is also presented as a function of invariant pair mass,
transverse momentum, and rapidity. The shapes of the transverse momentum and
rapidity spectra from the p+d and p+p systems are found to be similar to one
another for each of the beam energies studied. The beam energy dependence of
the integrated cross sections is also presented.Comment: 15 pages and 16 figure
Clinical trial evidence supporting US Food and Drug Administration approval of novel cancer therapies between 2000 and 2016
Importance: Clinical trial evidence used to support drug approval is typically the only information on benefits and harms that patients and clinicians can use for decision-making when novel cancer therapies become available. Various evaluations have raised concern about the uncertainty surrounding these data, and a systematic investigation of the available information on treatment outcomes for cancer drugs approved by the US Food and Drug Administration (FDA) is warranted. Objective: To describe the clinical trial data available on treatment outcomes at the time of FDA approval of all novel cancer drugs approved for the first time between 2000 and 2016. Design, Setting, and Participants: This comparative effectiveness study analyzed randomized clinical trials and single-arm clinical trials of novel drugs approved for the first time to treat any type of cancer. Approval packages were obtained from drugs@FDA, a publicly available database containing information on drug and biologic products approved for human use in the US. Data from January 2000 to December 2016 were included in this study. Main Outcomes and Measures: Regulatory and clinical trial characteristics were described. For randomized clinical trials, summary treatment outcomes for overall survival, progression-free survival, and tumor response across all therapies were calculated, and median absolute survival increases were estimated. Tumor types and regulatory characteristics were assessed separately. Results: Between 2000 and 2016, 92 novel cancer drugs were approved by the FDA for 100 indications based on data from 127 clinical trials. The 127 clinical trials included a median of 191 participants (interquartile range [IQR], 106-448 participants). Overall, 65 clinical trials (51.2%) were randomized, and 95 clinical trials (74.8%) were open label. Of 100 indications, 44 indications underwent accelerated approval, 42 indications were for hematological cancers, and 58 indications were for solid tumors. Novel drugs had mean hazard ratios of 0.77 (95% CI, 0.73-0.81; I2 = 46%) for overall survival and 0.52 (95% CI, 0.47-0.57; I2 = 88%) for progression-free survival. The median tumor response, expressed as relative risk, was 2.37 (95% CI, 2.00-2.80; I2 = 91%). The median absolute survival benefit was 2.40 months (IQR, 1.25-3.89 months). Conclusions and Relevance: In this study, data available at the time of FDA drug approval indicated that novel cancer therapies were associated with substantial tumor responses but with prolonging median overall survival by only 2.40 months. Approval data from 17 years of clinical trials suggested that patients and clinicians typically had limited information available regarding the benefits of novel cancer treatments at market entry
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