Estudio de Caso de Proceso de Vinculación de Personal del Centro de Atención y Ventas de Claro Móvil Villavicencio.

85 h.El estudio de caso para el proceso de vinculación de personal del Centro de Atención y Ventas de Claro Móvil Villavicencio, busca garantizar el cumplimiento de los objetivos empresariales con la participación activa de todos sus colaboradores. Así mismo, ofrecer posibles soluciones en cuanto a la problemática en el proceso de vinculación de personal que requiere el mismo. El marco teórico identificó autores que contribuyen a la solución del problema de investigación, en el que se versa sobre la temática identificada.Resultado para obtener el título de Administrador de Empresas, Tesis (Administración de Empresas) Universidad de los Llanos. Facultad de Ciencias Económicas. Escuela de Administración y Negocios. Programa de Administración de Empresas. 2016PregradoAdministración de Empresas (jornadas diurna y nocturna

Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials

<p>Abstract</p> <p>Background</p> <p>Subgroup analyses in randomized trials examine whether effects of interventions differ between subgroups of study populations according to characteristics of patients or interventions. However, findings from subgroup analyses may be misleading, potentially resulting in suboptimal clinical and health decision making. Few studies have investigated the reporting and conduct of subgroup analyses and a number of important questions remain unanswered. The objectives of this study are: 1) to describe the reporting of subgroup analyses and claims of subgroup effects in randomized controlled trials, 2) to assess study characteristics associated with reporting of subgroup analyses and with claims of subgroup effects, and 3) to examine the analysis, and interpretation of subgroup effects for each study's primary outcome.</p> <p>Methods</p> <p>We will conduct a systematic review of 464 randomized controlled human trials published in 2007 in the 118 Core Clinical Journals defined by the National Library of Medicine. We will randomly select journal articles, stratified in a 1:1 ratio by higher impact versus lower impact journals. According to 2007 ISI total citations, we consider the <it>New England Journal of Medicine, JAMA, Lancet, Annals of Internal Medicine</it>, and <it>BMJ </it>as higher impact journals. Teams of two reviewers will independently screen full texts of reports for eligibility, and abstract data, using standardized, pilot-tested extraction forms. We will conduct univariable and multivariable logistic regression analyses to examine the association of pre-specified study characteristics with reporting of subgroup analyses and with claims of subgroup effects for the primary and any other outcomes.</p> <p>Discussion</p> <p>A clear understanding of subgroup analyses, as currently conducted and reported in published randomized controlled trials, will reveal both strengths and weaknesses of this practice. Our findings will contribute to a set of recommendations to optimize the conduct and reporting of subgroup analyses, and claim and interpretation of subgroup effects in randomized trials.</p

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Aviary Federico Carlos Lehmann

Los ecosistemas del pacífico colombiano se han visto afectados por la deforestación y minería ilegal, resultando en la pérdida de biodiversidad de flora y fauna. Cerca de 118 especies de aves de bosques húmedos de los Andes y la Costa Pacífica se encuentran en riesgo de extinción. Ellas juegan un papel un papel fundamental en el ecosistema ya que cumplen funciones como la distribución de semillas. Surge la necesidad de educar y generar conciencia ambiental para recalcar la importancia de los ecosistemas y las aves. Este proyecto busca exponer la problemática que viven las aves y promover el cuidado de los ecosistemas del Pacífico. Esto se hará mediante exposiciones, clases didácticas sobre la avifauna e interacción con el entorno en el municipio de Quibdó. Además, generará un impacto social y económico en la región al impulsar el ecoturismo. Las 2.74 hectáreas del proyecto constan de zonas de aves protegidas, escenarios, senderos, lago y zonas verdes que servirán como hábitat para las aves y espacio de recreación para los visitantes. El edificio principal contará con un aula interactiva, sala de exposiciones, laboratorios de investigación equipados con tecnologías y una zona verde en la cubierta que sirva como mirador. El diseño de estos espacios sigue la topografía, los estudios de suelos, hidrológicos y de transporte para dar con el diseño de cimentaciones, la estructura, vías y pavimentos. Con el estudio ambiental se obtuvo planes para mitigar los efectos de urbanización y construcción de la obra debido a la tala de árboles. Además, debido a la ausencia de redes hidrosanitarias, se optó por estanques de captación de agua lluvia como suministro de agua potable y una PTAR para el tratamiento de aguas residuales. Con la realización de este proyecto, se aplicaron todos los conocimientos adquiridos a lo largo de nuestra carrera de Ingeniería Civil y se utilizaron para dar con una solución de la problemática que es la pérdida de biodiversidad.The ecosystems of the Colombian Pacific have been affected by deforestation and illegal mining, resulting in loss of biodiversity of flora and fauna. About 118 species of birds from the humid forests of the Andes and the Pacific Coast are at risk of extinction. These play a fundamental role in the ecosystem since they fulfill functions such as the distribution of seeds. Therefore, there is a need to educate and generate environmental awareness to emphasize the importance of ecosystems and birds. This project seeks to expose the problems that birds live and promote the care of the ecosystems of the Pacific. This will be done through exhibitions, educational classes on birdlife and interaction with the environment in the city of Quibdó. In addition, it will generate a social and economic impact in the region by promoting ecotourism. The 2.74 hectares of the project consist of protected bird areas, stages, trails, lake and green areas that will serve as habitat for birds and recreation space for visitors. The main building will have an interactive room, an exhibition hall, research laboratories equipped with technologies and a green area on the roof that will serve as a lookout point. The design of these spaces follows the topography, soil, hydrological and transport studies to find the design of foundations, the structure, roads and pavements. With the environmental study, plans were obtained to mitigate the effects of urbanization and construction of the work due to the felling of trees. In addition, due to the absence of hydrosanitary networks, rainwater catchment ponds were chosen as a drinking water supply and a WWTP for wastewater treatment. With the completion of this project, all the knowledge acquired throughout our Civil Engineering career was applied and was used to find a solution to the problem that is the loss of biodiversity