Explanation-Based Decision Making

In complex decision tasks the decision maker frequently constructs a summary representation of the relevant evidence in the form of a causal explanation and relies on that representation, rather than the "raw" evidence base, to select a course of action from a choice set of decision alternatives. We introduce a general model for this form of decision making, called explanation-based decision making, because of the central roleplayed by the intervening evidence summary. Several original empirical studies of judicial decision making, a prototype of the class of explanation-based decision tasks, are reviewed and the findings are adduced in support of the explanation-based decision model. In legal decision making tasks subjects spontaneously construct evidence summaries in the form of stories comprising the perceived underlying causal relationships among decision relevant events. These explanations are primary mediators (i.e., causes)of the subjects' decisions

Drifting vertical current meter, moored aanderaa thermistor chain, and XBT data : Jasin 1978 Atlantis-II cruise (102)

The report presents summaries of three data sets taken at and in the vicinity of the oceanographic moorings deployed in the 1978 Joint Air-Sea Inte raction Project (JASIN). The data sets are: (1) the temperature, pressure and vertical motion records from the freely drifting Vertical Current Meters (VCMs) deployed from the ATLANTIS II, (2) the temperature data from the Aanderaa thermistor chains on W.H.O.I. mooring 653, designated as JASIN mooring W3, and (3) the expendable bathythermograph (XBT) data collected from the ATLANTIS II while participating in the JASIN Project.Prepared for the Office of Naval Research under Contract N00014-76-C-0197; NR 083- 400 and for the National Science Foundation under Grant OCE 77-25803

TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation.

FICZ and TCDD, two high-affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic differences in AhR activation, although differences in sensitivity to metabolism complicate the issue. TCDD is resistant to AhR-induced metabolism and produces sustained AhR activation following a single dose in the μg/kg range, whereas FICZ is rapidly metabolized and AhR activation is transient. Nonetheless, prior studies comparing FICZ with TCDD have generally used the same 10-50 μg/kg dose range, and thus the two ligands would not equivalently activate AhR. We hypothesized that high-affinity AhR ligands can promote CD4+ T cell differentiation into both Th17 cells and Tregs, with fate depending on the extent and duration of AhR activation. We compared the immunosuppressive effects of TCDD and FICZ, along with two other rapidly metabolized ligands (ITE and 11-Cl-BBQ) in an acute alloresponse mouse model. The dose and timing of administration of each ligand was optimized for TCDD-equivalent Cyp1a1 induction. When optimized, all of the ligands suppressed the alloresponse in conjunction with the induction of Foxp3- Tr1 cells on day 2 and the expansion of natural Foxp3+ Tregs on day 10. In contrast, a low dose of FICZ induced transient expression of Cyp1a1 and did not induce Tregs or suppress the alloresponse but enhanced IL-17 production. Interestingly, low doses of the other ligands, including TCDD, also increased IL-17 production on day 10. These findings support the conclusion that the dose and the duration of AhR activation by high-affinity AhR ligands are the primary factors driving the fate of T cell differentiation

Measuring Cortisol in the Classroom with School-Aged Children—A Systematic Review and Recommendations

The collection of salivary cortisol has been chosen as one of the least intrusive, easiest to collect, analyze, and store methods of obtaining information on physiological changes. It is, however, not clear what the best practice is when collecting salivary cortisol from children within the school setting. The aim of this systematic review is to evaluate the feasibility of cortisol collection in schools for future research and to make recommendations for best practice. The review included 25 peer-reviewed articles from seven databases. The hypotheses of the included studies vary, but they all use cortisol as a diurnal, baseline, or acute measure, or to measure the effect of an intervention. Two methods of salivary cortisol collection were preferred by most of the research, i.e., passive drool or cotton Salivettes. The review has concluded that cortisol is a physiological marker that can be successfully measured in school-based research. However, there are discrepancies across studies when evaluating the collection guidelines, protocols, and instructions to participants as well as transparency of the success rate of obtaining all samples. Recommendations are made for future research to address and avoid such discrepancies and improve cross-study comparisons by implementing standard protocol guidelines

Atlantis II : cruise 102 : preliminary CTD data from Jasin 1978

102 profiles of conductivity, temperature, and depth (pressure) (CTD) were taken in the JASIN area northwest of Scotland in July-September 1978. These stations consisted of single and yo-yo profiles. The data set includes 14 stations taken near Anton Dohrn Seamount at 57°30'N, 11°W . Plotted profiles of temperature, salinity, sigma-theta, and buoyancy frequency, and a listing of the data, are included for most stations.Prepared for the Office of Naval Research under Contract N00014-76-G-0197, NR 083-400, and for the National Science Foundation under Grant OCE77-25803

Opinion Paragraph Writing Intervention for Students with Significant Disability

Increasingly, technology has been used to provide access to academic curricula for students with moderate to severe intellectual disability. In the current pilot study, we used a multiple probe across participants design to evaluate the effectiveness of a technology-based instructional package on the opinion writing skills of three middle school students with moderate and severe intellectual disability. Findings suggest that the intervention resulted in improved performance across all three participants and that all participants maintained performance at levels greater than baseline. Limitations and implications for practice and future research are discussed

An Exploration of Novice Programmers' Comprehension of Conditionals in Imperative and Functional Programming

2Students of introductory programming courses are expected to develop higher-order thinking skills to inspect, understand and modify code. However, although novices can correctly write small programs, they appear to lack a more abstract, comprehensive grasp of basic constructs, such as conceiving the overall effect of alternative conditional flows. This work takes a little-explored perspective on the comprehension of tiny programs by asking students to reason about reversing conditionals in either an imperative or a functional context. More specifically, besides deciding if the given constructs can be reversed, students had to justify their choice by writing a reversing program or by providing suitable counterexamples. The students’ answers to four reversibility questions have been analysed through the lens of the SOLO taxonomy. 45% of students correctly identified the reversibility for the four code items; furthermore, more than 50% of each cohort were able to provide correct justifications for at least three of their four answers. Most incorrect answers were due to failures to consider border cases or to edit the conditional expressions appropriately to reverse the construct. Differences in comprehension between functional and imperative languages are explored indicating the explicit else paths of the functional examples facilitate comprehension compared with the implicit else (no update) of its imperative counterpart.partially_openopenMirolo, Claudio; Izu, CruzMirolo, Claudio; Izu, Cru

Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice.

Aryl hydrocarbon receptor (AhR) activation by high-affinity ligands mediates immunosuppression in association with increased regulatory T cells (Tregs), making this transcription factor an attractive therapeutic target for autoimmune diseases. We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ), a nanomolar affinity AhR ligand with immunosuppressive activity and favorable pharmacologic properties. In this study, we tested the consequences of AhR activation in the NOD model. Oral 10-Cl-BBQ treatment prevented islet infiltration without clinical toxicity, whereas AhR-deficient NOD mice were not protected. Suppression of insulitis was associated with an increased frequency, but not total number, of Foxp3(+) Tregs in the pancreas and pancreatic lymph nodes. The requirement for Foxp3(+) cells in AhR-induced suppression of insulitis was tested using NOD.Foxp3(DTR) mice, which show extensive islet infiltration upon treatment with diphtheria toxin. AhR activation prevented the development of insulitis caused by the depletion of Foxp3(+) cells, demonstrating that Foxp3(+) cells are not required for AhR-mediated suppression and furthermore that the AhR pathway is able to compensate for the absence of Foxp3(+) Tregs, countering current dogma. Concurrently, the development of disease-associated CD4(+)Nrp1(+)Foxp3(-)RORγt(+) cells was inhibited by AhR activation. Taken together, 10-Cl-BBQ is an effective, nontoxic AhR ligand for the intervention of immune-mediated diseases that functions independently of Foxp3(+) Tregs to suppress pathogenic T cell development

AhR activation increases IL-2 production by alloreactive CD4+ T cells initiating the differentiation of mucosal-homing Tim3+ Lag3+ Tr1 cells.

Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes the development of regulatory T (Treg) cells. Although AhR-induced Foxp3+ Treg cells have been well studied, much less is known about the development and fate of AhR-induced Type 1 Treg (AhR-Tr1) cells. In the current study, we identified the unique transcriptional and functional changes in murine CD4+ T cells that accompany the differentiation of AhR-Tr1 cells during the CD4+ T-cell-dependent phase of an allospecific cytotoxic T lymphocyte (allo-CTL) response. AhR activation increased the expression of genes involved in T-cell activation, immune regulation and chemotaxis, as well as a global downregulation of genes involved in cell cycling.  Increased IL-2 production was responsible for the early AhR-Tr1 activation phenotype previously characterized as CD25+ CTLA4+ GITR+ on day 2. The AhR-Tr1 phenotype was further defined by the coexpression of the immunoregulatory receptors Lag3 and Tim3 and non-overlapping expression of CCR4 and CCR9. Consistent with the increased expression of CCR9, real-time imaging showed enhanced migration of AhR-Tr1 cells to the lamina propria of the small intestine and colon. The discovery of mucosal imprinting of AhR-Tr1 cells provides an additional mechanism by which therapeutic AhR ligands can control immunopathology