Draft genome sequence of a novel “Candidatus Liberibacter” species detected in a Zanthoxylum species from Bhutan

The draft genome sequence of a novel “Candidatus\ua0Liberibacter” species detected in an unidentified species of\ua0Zanthoxylum\ua0(Rutaceae) collected in Bhutan is reported. The total length is 1,408,989 bp with 1,169 coding sequences in 96 contigs, a GC content of 37.3%, and 76 to 77% average nucleotide identity with several other “Ca. Liberibacter” species

Transhumance, livestock mobility and mutual benefits between crop and livestock production

Grazing-based livestock production, named pastoralism, is classified into nomadism, transhumance and agro-pastoralism. Transhumance is characterised by the seasonal and recurring movement of livestock whereby seasonal grazing areas and routes for livestock movement are fixed. All grazing based livestock production systems including transhumance are constrained globally for a variety of reasons. The major threats to the system are globalisation, nationalisation or privatisation of rangelands, national parks and community forestry policies restricting free grazing and shortage of labour. The collapse or decline of such social-ecological systems (SESs), which have existed for over 1000s years, often induces adverse impacts on societies and ecosystems. Here we review the literature on transhumance, and discuss reasons for transhumance, and the associated advantages and disadvantages of livestock movement in transhumance. Our review also focuses on how the integration of crop and livestock production in transhumance derives mutual benefits. The review indicates that the seasonal movement of livestock is an ecological necessity in areas with harsh climates and low pasture production. Transhumance is also a herders’ adaptive management to adjust to variable grazing resources and environmental conditions. The disadvantages of seasonal movement of livestock such as greater herding labour required and expenditure of more energy for livestock, are far outweighed by the ecological advantages. Some of these are: to minimise grazing competition and to protect rangeland pastures from being overgrazed. Our review also indicates that the integration of crop and livestock production derives mutual benefits and contributes for their enhanced sustainability

Challenges for achieving safe and effective radical cure of P. vivax – a round table discussion of the APMEN Vivax Working Group

The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network (APMEN) Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes. In this review the key discussion points are presented and grouped into five themes: (i) current barriers for glucose-6-phosphate deficiency (G6PD) testing prior to PQ radical cure, (ii) necessary properties of G6PD tests for wide scale deployment, (iii) the promotion of G6PD testing, (iv) improving adherence to PQ regimens and (v) the challenges for future tafenoquine (TQ) roll out. Robust point of care (PoC) G6PD tests are needed, which are suitable and cost-effective for clinical settings with limited infrastructure. An affordable and competitive test price is needed, accompanied by sustainable funding for the product with appropriate training of healthcare staff, and robust quality control and assurance processes. In the absence of quantitative PoC G6PD tests, G6PD status can be gauged with qualitative diagnostics, however none of the available tests is currently sensitive enough to guide TQ treatment. TQ introduction will require overcoming additional challenges including the management of severely and intermediately G6PD deficient individuals. Robust strategies are needed to ensure that effective treatment practices can be deployed widely, and these should highlight the caveats as well as the benefits of radical cure for both the patients and the community. Widespread access to quality controlled G6PD testing will be critical