The Long-Term Effects of Chemo Radiotherapy on Oral Health and Dental Development in Childhood Cancer

The improvement in survival and local control measures in children with neoplasm in the head and neck region may lead to increased iatrogenic adverse effects of treatment. The aim of this study was to report a new case of the long-term effects of chemoradiotherapy on oral health and dental development in a patient treated for Hodgkin’s disease at an early age. In this case report, a 26-year-old female is presented, who at the age of 5 years received chemotherapy and radiotherapy for Hodgkin’s disease in the neck region. The patient consulted the Department of Oral Medicine because of dental changes and tooth loss despite adequate dental care and oral hygiene. Clinical examination revealed loose teeth and inflamed gingiva of the mandible, x-ray showed premature root resorption, V-shaped and shortened roots and alveolar bone loss. After examination, the patient was referred for extracting the mandibular teeth and then wassent to the prosthetics department. Therefore, in order to decrease dental treatment sequelae in patients who have had cured malignant disease, these cases should have life-long dental care and follow-up

When challenges hinder: An investigation of buyer-imposed stressors on supplier flexibility

Working with buyers may drive business growth but can also induce supplier stress. Drawing on Job Demands–Resources (JD-R) theory, this study explored how buyer-imposed work stressors affect supplier flexibility. Employing a scenario-based experiment involving 338 managers, we found that the imposition of challenge stressors increases supplier flexibility when hindrance stressors are low. Conversely, when hindrance stressors are high, imposing challenge stressors reduces supplier flexibility. We also found that supplier bricolage negatively moderates the relationship between buyer-imposed challenge stressors and supplier flexibility. Specifically, we confirmed that suppliers with higher bricolage are less willing to provide flexibility in response to challenge stressors. For practitioners, our study not only identified the type of work stressors they should impose on suppliers to boost flexibility but also highlighted bricolage as an important moderating factor

Building subsidiary local responsiveness: (when) does the directionality of intrafirm knowledge transfers matter?

The present study focuses on effects of subsidiary internal knowledge-based activities—knowledge transfer and reverse knowledge transfer—and absorptive capacity on local responsiveness. We also examine whether absorptive capacity, shared values, and psychological safety, representing constituents of the motivation-opportunity-ability model of behavior, moderate relationships of subsidiary internal knowledge-based activities with responsiveness. Based on a sample of 173 Chinese subsidiaries, the results suggest knowledge transfer and absorptive capacity facilitate local responsiveness. Shared values moderates positively and absorptive capacity negatively, the relationship between knowledge transfer and responsiveness. Psychological safety strengthens the link between reverse knowledge transfer and local responsiveness

Efecto de diferentes métodos de extracción sobre la actividad antioxidante del azafrán, contenido total de fenoles y crocina y efecto protector del extracto de azafrán sobre la estabilidad oxidativa de los aceites vegetales comunes

Saffron consists of bioactive compounds with health-promoting properties and is mainly used in medicine, flavoring and coloring. In this study, we aimed to investigate the effect of extraction methods on the antioxidant activity of saffron (Crocus sativus L.) extracts (SE) and to evaluate the antioxidant performance of SE in vegetable oils. Saffron stigmas were extracted in water, ethanol, methanol, and their combinations using maceration extraction (ME), ultrasonic-assisted extraction (UAE), microwave-assisted extraction (MAE), and the combination of UAE with MAE. The results showed that the sample extracted by methanol/water (50:50) using the combination of UAE with MAE methods had the highest amount of total phenolic content (31.56 mg/g GAE) and antioxidant activity (83.24% inhibition). The extract with the highest antioxidant activity was freeze-dried before incorporation into oil samples. Freeze-dried SE contained trans-crocin-4 and trans-crocin-3 (most abundant constituents), kaempferol, and picrocrocin. Moreover, the addition of SE at 1000 ppm resulted in a significant increase in the oxidative stability of canola (CAO), sunflower (SO), and corn oil (COO).El azafrán contiene compuestos bioactivos con propiedades promotoras de la salud de uso destacado en medicina, saborizante y colorante. En este estudio, nuestro objetivo fue investigar el efecto de los métodos de extracción sobre la actividad antioxidante de los extractos (EA) de azafrán (Crocus sativus L.) y evaluar el rendimiento antioxidante de EA en aceites vegetales. Los estigmas de azafrán se extrajeron en agua, etanol, metanol y sus combinaciones, mediante extracción por maceración (EM), extracción asistida por ultrasonidos (EAU), extracción asistida por microondas (EAM) y la combinación de EAU con EAM. Los resultados mostraron que la muestra extraída con metanol/agua (50:50) usando la combinación de métodos EAU con EAM tuvo la mayor cantidad de fenoles totales (31.56 mg/g GAE) y actividad antioxidante (83.24 % de inhibición). El extracto que incluía la mayor actividad antioxidante se liofilizó antes de incorporarlo a las muestras de aceite. El SE liofilizado contenía trans-crocina-4 y trans-crocina-3 (los constituyentes más abundantes), kaempferol y picrocrocina. Además, la adición de 1000 ppm de EA dio como resultado un aumento significativo en la estabilidad oxidativa del aceite de canola (C), girasol (G) y maíz (M)

Postconditioning is protective in renal reperfusion injury only in male rats. A gender difference study

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