CD74-dependent Deregulation of the Tumor Suppressor Scribble in Human Epithelial and Breast Cancer Cells

The γ subunit of the major histocompatibility complex (MHC) class II complex, CD74, is overexpressed in a significant proportion of metastatic breast tumors, but the mechanistic foundation and biologic significance of this phenomenon are not fully understood. Here, we show that when CD74 is overexpressed in human cancer and noncancerous epithelial cells, it interacts and interferes with the function of Scribble, a product of a well-known tumor suppressor gene. Furthermore, using epithelial cell lines expressing CD74 under the control of tetracycline-inducible promoter and quantitative high-resolution mass spectrometry, we demonstrate that, as a result of CD74 overexpression, the phosphorylation pattern of the C-terminal part of Scribble undergoes specific changes. This is accompanied with a translocation of the protein from the sites of cell-to-cell contacts at the plasma membrane to the cytoplasm, which is likely to effectively enhance the motility and invasiveness of the cancer cells. © 2013 Neoplasia Press, Inc. All rights reserved

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

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Impact properties of electron beam welds of V-4Ti-4Cr alloys NIFS-HEAT-2 and CEA-J57

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Effect of post-weld heat treatment on microstructure, hardness and low-temperature impact toughness of electron beam welds of NIFS-HEAT-2 and CEA-J57 heats of V–4Ti–4Cr alloy

Bead-on-plate electron beam welding in high vacuum atmosphere was applied to the plates of NIFS- HEAT-2 and CEA-J57 heats of V–4Ti–4Cr alloy. Effect of post-weld heat treatment (PWHT) in the temper- ature range 673–1273 K on the hardness, impact toughness at 77 K and microstructure of weld metal was investigated. After PWHT at 773 K, hardness of weld metal slightly decreases from 180 HV 100 (as-welded state) to ∼170 HV 100 while absorbed energy increases up to ∼10 J showing ductile fracture mode. PWHT at 973 K results in re-hardening of weld metal up to ∼180 HV 100 caused by re-precipitation of Ti–C,O,N precipitates and corresponding decreasing absorbed energy to ∼2 J with brittle fracture mode. PWHT in- between 1073–1273 K results in gradual recovery of hardness towards values comparable with those of base metal. Impact toughness (77 K) of weld metal after PWHT at 1073K is not recovered nether to the value in as-welded state nor to that one of base metal

Evidence for B to K eta' gamma Decays at Belle

We present the results of a search for the radiative decay (B -> K eta' gamma) and find evidence for (B^+ -> K^+ eta' gamma) decays at the 3.3 standard deviation level with a partial branching fraction of (3.6 +/- 1.2 +/- 0.4) x 10e-6, where the first error is statistical and the second systematic. This measurement is restricted to the region of combined (K eta') invariant mass less than 3.4GeVc^2. A 90% confidence level upper limit of 6.4 x 10e-6 is obtained for the decay (B^0 -> K^0 eta' gamma) in the same (K eta') invariant mass region. These results are obtained from a 605 fb^-1 data sample containing 657 x 10e6 B anti-B pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider.Comment: 5 pages, 4 figures. Submitted to PRD-RC on 6/8/0

Search for Lepton Flavor and Lepton Number Violating tau Decays into a Lepton and Two Charged Mesons

We search for lepton flavor and lepton number violating tau decays into a lepton (ell = electron or muon) and two charged mesons (h,h' = pi^\pm or K^\pm), tau- -> ell-h+h'- and tau- -> ell+h-h'-, using 671 fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We obtain 90% C.L. upper limits on the branching fractions in the range (4.4-8.8)x10^{-8} for tau -> ehh', and (3.3-16)x10^{-8} for tau -> muhh' processes. These results improve upon previously published upper limits by factors between 1.6 to 8.8.Comment: 15 page, 7 figures, submitted to Phys. Lett.