Phenotypic spectrum and clinical course of single large-scale mitochondrial DNA deletion disease in the paediatric population : a multicentre study

Background Large-scale mitochondrial DNA deletions (LMD) are a common genetic cause of mitochondrial disease and give rise to a wide range of clinical features. Lack of longitudinal data means the natural history remains unclear. This study was undertaken to describe the clinical spectrum in a large cohort of patients with paediatric disease onset. Methods A retrospective multicentre study was performed in patients with clinical onsetPeer reviewe

Organising in the Anthropocene: An Ontological Outline for Ecocentric Theorising

As a response to anthropogenic ecological problems, a group of organisation scholars have acknowledged the importance of ecocentric theorising that takes materiality and non-human objects seriously. The purpose of this article is to examine the philosophical basis of cocentric organisation studies and develop an ontological outline for ecocentric theorising in the Anthropocene. The paper identifies the central premises of ecocentric organisations from the previous literature, and complements the theory with a set of ontological qualities common to all objects. The study draws on recent advances in object-oriented and ecological philosophies to present three essential qualities of objects, namely autonomy, uniqueness, and intrinsicality. The paper discusses how these qualities are critical in reclaiming the lost credibility and practical relevance of ecocentrism in both organisational theory and the sustainability sciences in general. To organise human activities in a sustainable manner in the new geological era, a new ontology is needed that not only includes materiality and non-humans in the analysis, but also leads to an ecologically and ethically broader understanding of ecospheric beings and their relationships