Recent Advances and Trends in the Dairy Field

Dairy products have been an important part of the human diet for most societies since the Neolithic period. Despite adherence to traditional products such as traditional cheese varieties, which are considered highly prestigious, being important, innovations in dairy products continue. Dairy science is among the oldest fields of food science and technology

Writing a synthesis versus reading: strategies involved and impact on comprehension

Little evidence is available regarding the differential impact of reading versus reading and writing on multiple source comprehension. The present study aims to: (1) compare the inferential comprehension performance of students in reading vs. reading/synthesis conditions; (2) explore the impact of performing the tasks on paper vs. on screen with Read&Answer (R&A) software; and (3) explore the extent to which rereading, notetaking, and the quality of the written synthesis can explain student's comprehension scores. For the students in the synthesis condition, we also examined the relationship between the quality of the synthesis they produced and the comprehension they achieved. 155 psychology undergraduates were randomly assigned either to the reading (n=78) or to the reading/synthesis condition (n=77). From this sample, 79 participants carried out the task with the Read&Answer software, and 76 solved the task on paper. All the students took a prior knowledge questionnaire, and read three complementary texts about the conception of intelligence. Students in the reading condition answered an inferential comprehension test, whereas students in the synthesis condition were asked to write a synthesis before taking the same test. Results show no differences in comprehension between students in the four conditions (task and media). There was no significant association between rereading and task condition. However, students in the synthesis condition were more likely to take notes. We found that two of the categories for the quality of the synthesis, textual organization and accuracy of content had an impact on inferential comprehension for the participants who wrote it. The quality of the synthesis mediated between student's prior knowledge and inferential comprehension

Alimentos irradiados

La industria alimentaria y las administraciones públicas realizan grandes esfuerzos para mejorar el mantenimiento de las condiciones higiénicas y evitar la contaminación de alimentos. Pese a estos esfuerzos siguen produciéndose un gran numero de procesos patológicos relacionados con los alimentos. Las buenas prácticas higiénicas pueden reducir el nivel de contaminación, pero algunos microorganismos patógenos resulta imposible eliminarlos, especialmente de aquellos alimentos que se comercializan crudos y con procesado mínimo. La irradiación se presenta como un método de descontaminación posible para este grupo de alimentos, especialmente válido como método de descontaminación final. Dosis de irradiación inferiores a 10 kGy (dependiendo del alimento y condiciones) son efectivas para eliminar posibles patógenos no esporulados, inactivar parásitos, tratar especias, condimentos y otros ingredientes secos, fruta fresca y productos de cuarta gama (vegetales frescos, limpios y envasados, listos para consumo). Respecto a la seguridad de los alimentos irradiados, está plenamente demostrado que no provoca la aparición de compuestos especiales y provoca una ligera reducción en el contenido de algunas vitaminas, que es equiparable a la producida por otros tratamientos tecnológicos. Se ha visto también que microorganismos que han sido sometidos a radiaciones y han sobrevivido a ellas se muestran más sensibles a las condiciones ambientales de estrés que aquellos que nunca han sido irradiados. Pese a que los organismos internacionales FAO y OMS presentan la irradiación como un método seguro, eficaz, limpio con el medio ambiente y energéticamente eficiente, los consumidores siguen estando desinformados y mostrándose reticentes a su utilización. En la actualidad se están llevando a cabo muchos sondeos, de los que se deriva que una correcta in formación al consumidor es el único método válido para conseguir la aceptación de esta tecnología. Las investigaciones actuales en este sector se centran en la optimización de su aplicación a alimentos concretos y en los posibles efectos sobre los materiales de envasado. Por lo que respecta a la aplicación industrial, se tiende a crear centros de tratamiento donde diferentes productores llevan sus materias a tratar. Se espera que esta tecnología presente una fuerte tendencia creciente en los próximos año

Learning through reading and writing tasks in higher education: what do students use, paper or screen?

The objective of this study was to identify and characterize the reading and writing tasks that university students perform to learn, taking into account the discipline (sciences vs humanities) and the support used (printed vs digital). Four hundred and four students completed an online questionnaire that included 13 tasks which involved reading-writing to learn the contents of the subject. The tasks varied according to their level of complexity, the number and type of sources needed, the level of composition required and the degree to which the information from the sources was processed. Students indicated performing, with higher frequency, tasks that promoted more superficial learning. Humanities students mentioned carrying out tasks that promoted deeper processing. Regarding the format of the materials used, science students reported using the digital format more frequently. However, printed support seemed to be more commonly used when students performed tasks to learn in a relatively superficial way the contents of the subjects. By contrast, students used the digital format to perform complex reading and writing tasksThis work was supported by the Institute of Educational Sciences (Universitat de Barcelona) under Grant REDICE14-1348. / Este trabajo ha recibido financiación del Institut de Ciències de l’Educació de la Universitat de Barcelona a través del programa REDICE14-134

Microorganismos para mejorar el estado de salud de individuos con trastornos relacionados con la ingesta de gluten

La presente invención aporta microorganismos para el tratamientode alergias alimentarias, más concretamente la enfermedad celiaca, así como métodos para su sección. Sus mecanismos de acción incluyen: (i) la regulación de la respuesta inmunológica innata y adaptativa; (ii) la reducción de la concentración de epítopos tóxicos en la luz intestinal; (iii) el fortalecimiento de la función barrera defensiva frente a bacterias y antígenos perjudiciales, y (iv) el aporte de actividades enzimáticas que favorecen la digestión.Peer reviewedConsejo Superior de Investigaciones Científicas (España)T3 Traducción de patente europe

Improving Questioning-Answering Strategies in Learning from Multiple Complementary Texts: an Intervention Study

Studies have shown that inferential questions encourage a more in-depth understanding of texts and that students need to learn appropriate strategies for answering them, particularly when they deal with multiple texts. In this experimental study, the authors aimed to improve 8th grade students' (13- to 14 years old) ability to answer intra- and intertextual inferential questions when they read one or multiple complementary texts. The intervention was implemented by a group of middle-school history teachers. Teachers in both the intervention and control groups (IG and CG, respectively) taught the same teaching unit using the same reading materials. However, teachers in the IG participated in 12 hours of professional development seminars on analysis of their classroom practice and how to improve their questioning strategies. Post-intervention results revealed that students in the IG were significantly better than those in the CG at answering intra- and intertextual inferential questions. This difference was maintained at follow-up (two months after finishing the intervention). Students in the IG also performed better than those in the CG at a learning test. These results confirm the value of teaching students how to answer complex questions, especially when they refer to more than one text. The findings also support the value of the professional development program that enables teachers to reflect on their practice

The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E(2)) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 μg/kg) of either E(2) or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E(2) and BPA induce an increase in pancreatic β-cell insulin content in an estrogen-receptor–dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 μg/kg/day. After 4 days of treatment with either E(2) or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia

Combined genetic and high-throughput strategies for the molecular diagnosis of inherited retinal dystrophies

Most diagnostic laboratories are confronted with the increasing demand for molecular diagnosis from patients and families and the ever-increasing genetic heterogeneity of visual disorders. Concerning Retinal Dystrophies (RD), almost 200 causative genes have been reported to date, and most families carry private mutations. We aimed to approach RD genetic diagnosis using all the available genetic information to prioritize candidates for mutational screening, and then restrict the number of cases to be analyzed by massive sequencing. We constructed and optimized a comprehensive cosegregation RD-chip based on SNP genotyping and haplotype analysis. The RD-chip allows to genotype 768 selected SNPs (closely linked to 100 RD causative genes) in a single cost-, time-effective step. Full diagnosis was attained in 17/36 Spanish pedigrees, yielding 12 new and 12 previously reported mutations in 9 RD genes. The most frequently mutated genes were USH2A and CRB1. Notably, RD3-up to now only associated to Leber Congenital Amaurosis- was identified as causative of Retinitis Pigmentosa. The main assets of the RD-chip are: i) the robustness of the genetic information that underscores the most probable candidates, ii) the invaluable clues in cases of shared haplotypes, which are indicative of a common founder effect, and iii) the detection of extended haplotypes over closely mapping genes, which substantiates cosegregation, although the assumptions in which the genetic analysis is based could exceptionally lead astray. The combination of the genetic approach with whole exome sequencing (WES) greatly increases the diagnosis efficiency, and revealed novel mutations in USH2A and GUCY2D. Overall, the RD-chip diagnosis efficiency ranges from 16% in dominant, to 80% in consanguineous recessive pedigrees, with an average of 47%, well within the upper range of massive sequencing approaches, highlighting the validity of this time- and cost-effective approach whilst high-throughput methodologies become amenable for routine diagnosis in medium sized labs

Understanding the physical, social, and emotional experiences of people with uncontrolled Type 2 diabetes: a qualitative study

The purpose of this study was to identify the perceptions, barriers, and facilitators of self-management of Type 2 diabetes mellitus (T2DM) to determine the factors to consider when developing and implementing a person-centered intervention in patients with poor glycemic control attending primary care.CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative included in Plan Nacional de I+D+I and cofinanced by Instituto de Salud Carlos III-Subdireccion General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER)

INTEGRA study protocol: primary care intervention in type 2 diabetes patients with poor glycaemic control

Background The management of hyperglycaemia and associated cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM) may reduce diabetes-related complications. The strategy to broaden the knowledge base of primary care professionals to improve health care has mainly been prompted by the current reality of limited resources and access to specialized care. The main objective of this study is to assess the effectiveness of comprehensive interventions focused on treatment intensification, decrease clinical inertia and reduce possible barriers to treatment adherence in patients with poorly controlled diabetes in a primary care setting. Methods This is a two-phase mixed method study, whose aims are the development of complex interventions and the assessment of their effectiveness. The main study outcome is a change in glycated haemoglobin (HbA1c) levels. The INTEGRA study is divided into two phases. Phase 1: A qualitative study with a phenomenological approach using semi-structured interviews with the objective of determining the factors related to the participants and health care professionals that influence the development and implementation of a specific intervention strategy aimed at patients with poor glycaemic control of T2DM in primary care. Phase 2: Exploratory intervention study to be conducted in Primary Health Care Centres in Catalonia (Spain), including 3 specific health care areas. The intervention study has two arms: Intervention Group 1 and 2. Each intervention group will recruit 216 participants (the same as in the control group) between the ages of 30 and 80 years with deficient glycaemic control (HbA1c > 9%). The control group will be established based on a randomized selection from the large SIDIAP (Sistema d’Informació per al desenvolupament de la Investigació en Atenció Primària) database of patients with comparable socio-demographic and clinical characteristics from the three provinces. Discussion This study is a comprehensive, pragmatic intervention based on glycaemic treatment intensification and the control of other cardiovascular risk factors. It is also aimed at improving treatment adherence and reducing clinical inertia, which could lead to improved glycaemic control and could likewise be feasible for implementation in the actual clinical practice of primary care.The study is partially supported by unrestricted grant from Sanofi. The study has also intramural support from Institut Universitari d’Investigació en Atenció Primària Jordi Gol. The funder does not have any role in writing the study protocol. This funding source will not have any role during its execution, analyses, interpretation of the data, or decision to submit results