298 research outputs found
11,11,12,12-tetracyanonaphtho-2,6-quinodimethane in Contact with Ferromagnetic Electrodes for Organic Spintronics
Spinterface engineering has shown quite important roles in organic
spintronics as it can improve spin injection or extraction. In this study,
11,11,12,12-tetracyanonaptho-2,6-quinodimethane (TNAP) is introduced as an
interfacial layer for a prototype interface of Fe/TNAP. We report an
element-specific investigation of the electronic and magnetic structures of
Fe/TNAP system by use of near edge X-Ray absorption fine structure (NEXAFS) and
X-ray magnetic circular dichroism (XMCD). Strong hybridization between TNAP and
Fe and induced magnetization of N atoms in TNAP molecule are observed. XMCD sum
rule analysis demonstrates that the adsorption of TNAP reduces the spin moment
of Fe by 12%. In addition, induced magnetization in N K-edge of TNAP has also
been found with other commonly used ferromagnets in organic spintronics, such
as La0.7Sr0.3MnO3 and permalloy, which makes TNAP a very promising molecule for
spinterface engineering in organic spintronics.Comment: 27 pages, 11 figure, 1 tabl
Fluoroquinolone resistance during 2000–2005 : An observational study
<p>Abstract</p> <p>Background</p> <p>Moxifloxacin is a respiratory fluoroquinolone with a community acquired pneumonia indication. Unlike other fluoroquinolones used in our healthcare system, moxifloxacin's urinary excretion is low and thus we hypothesized that increased use of moxifloxacin is associated with an increase in fluoroquinolone resistance amongst gram negative uropathogens.</p> <p>Methods</p> <p>All antibiograms for Gram negative bacteria were obtained for 2000 to 2005. The defined daily dose (DDD) for each fluoroquinolone was computed according to World Health Organization criteria. To account for fluctuation in patient volume, DDD/1000 bed days was computed for each year of study. Association between DDD/1000 bed days for each fluoroquinolone and the susceptibility of Gram negative bacteria to ciprofloxacin was assessed using Pearson's Correlation Coefficient, r.</p> <p>Results</p> <p>During the study period, there were 48,261 antibiograms, 347,931 DDD of fluoroquinolones, and 1,943,338 bed days. Use of fluoroquinolones among inpatients decreased from 237.2 DDD/1000 bed days in 2000 to 115.2 DDD/1000 bed days in 2005. With the exception of <it>Enterobacter aerogenes</it>, moxifloxacin use was negatively correlated with sensitivity among all 13 Gram negative species evaluated (r = -0.07 to -0.97). When the sensitivities of all Gram negative organisms were aggregated, all fluoroquinolones except moxifloxacin were associated with increased sensitivity (r = 0.486 to 1.000) while moxifloxacin was associated with decreased sensitivity (r = -0.464).</p> <p>Conclusion</p> <p>Moxifloxacin, while indicated for empiric treatment of community acquired pneumonia, may have important negative influence on local antibiotic sensitivities amongst Gram negative organisms. This effect was not shared by other commonly used members of the fluoroquinolone class.</p
Experimental analysis on the influence of nozzle geometry over the dispersion of liquid n-dodecane sprays
[EN] Understanding and controlling mixing and combustion processes is fundamental in
order to face the challenges set by the ever more demanding pollutant regulations
and fuel consumption standards of direct injection diesel engines. The fundamentals
of these processes haven been long studied by the diesel spray community from both
experimental and numerical perspectives. However, certain topics, such as the influence
of nozzle geometry over the spray atomization, mixing, and combustion process, are
still not completely well understood and predicted by numerical models. The present
study seeks to contribute to the current understanding of this subject, by performing
state of the art optical diagnostics to liquid sprays injected through two singe-hole
nozzles of different conicity. The experiments were carried out in a nitrogen-filled constantpressure-flow
facility. Back pressures were set to produce the desired engine-like density
conditions in the chamber, at room temperature. The experimental setup consists in a
diffused back-illumination setup with a fast pulsed LED light source and a high-speed
camera. The diagnostics focused on detecting the liquid spray contour and evaluating
the influence of nozzle geometry over the time-resolved and quasi-steady response of
the spray dispersion, at similar injection conditions. Results show a clear influence of
nozzle geometry on spray contour fluctuations, where the cylindrical nozzle seems to
produce larger dispersion in both time-resolved fluctuations and quasi-steady values,
when compared to the conical nozzle. This evidences that the turbulence and radial
velocity profiles originated at the cylindrical nozzle geometry are able to affect not only the
microscopic scales inside the nozzle, but also macroscopic scales, such as the steady
spray. Observations from this study indicate that the effects of the flow characteristics
within the nozzle are carried on to the first millimeters of the spray, in which the rest of
the spray formation downstream is pre-defined.This work was sponsored by Ministerio de EconomĂa y Competitividad of the Spanish Government in the frame of the Project “ComprensiĂłn de la influencia de combustibles no convencionales en el proceso de inyecciĂłn y combustiĂłn tipo diesel,” Reference TRA2012-36932. Additionally, the optical equipment used for the project was purchased with funding from Ministerio de EconomĂa y Competitividad FEDER-ICTS-2012-06. The authors would finally like to thank JosĂ© Enrique Del Rey and MarĂa del Carmen Tomás for their collaboration in the setup of the experiments and laboratory work.Payri, R.; Salvador, F.; Gimeno, J.; Viera-Sotillo, JP. (2015). Experimental analysis on the influence of nozzle geometry over the dispersion of liquid n-dodecane sprays. Frontiers in Mechanical Engineering. 1. https://doi.org/10.3389/fmech.2015.00013S
Finite Element Analysis of Electrically Excited Quartz Tuning Fork Devices
Quartz Tuning Fork (QTF)-based Scanning Probe Microscopy (SPM) is an important field of research. A suitable model for the QTF is important to obtain quantitative measurements with these devices. Analytical models have the limitation of being based on the double cantilever configuration. In this paper, we present an electromechanical finite element model of the QTF electrically excited with two free prongs. The model goes beyond the state-of-the-art of numerical simulations currently found in the literature for this QTF configuration. We present the first numerical analysis of both the electrical and mechanical behavior of QTF devices. Experimental measurements obtained with 10 units of the same model of QTF validate the finite element model with a good agreement
Attitudes to antipsychotic drugs and their side effects: a comparison between general practitioners and the general population
BACKGROUND: Attitudes towards antipsychotic medication play an important part in the treatment for schizophrenia and related disorders. We aimed measuring general practitioners' attitudes to antipsychotic drugs and their adverse side effects and comparing these with the attitudes of the general population. METHODS: Analysis and comparison of two representative samples, one comprising 100 General Practitioners (GPs), the other 791 individuals randomly selected from the general population. The setting was the German speaking cantons of Switzerland. RESULTS: General practitioners have significantly more positive attitudes towards anti-psychotic drugs than the general public. They reject widespread prejudices about the use of anti-psychotic medication significantly more than the general population. In particular the risk of dependency was assessed as 'low' by GP's (80%), in contrast to only 18% of the general population sample. In no instance did a majority of the GPs advise not tolerating any of the 10 possible adverse effects presented in this study. This is in marked contrast to the general population sample, where a majority recommended discontinuation for movement disorder (63%), strong tremor (59%), risk of dependency (55%) and feelings of unrest (54%). CONCLUSION: As well as effective management of side-effects being a vital aspect of patient and carer education, prescribing doctors need to be aware that their mentally ill patients are likely to be confronted with extremely negative public attitudes towards antipsychotic medication and with strong pressures to stop taking their medication in the event of side-effects
Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)
Cultural competence in working with the Arab Australian community: a conceptual review and the experience of the Arab Council Australia (ACA) gambling help counselling service
Programmable polymer light emitting transistors with ferroelectric polarization-enhanced channel current and light emission
Empiric therapy for hospital-acquired, Gram-negative complicated intra-abdominal infection and complicated urinary tract infections: a systematic literature review of current and emerging treatment options
Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland
<p>Abstract</p> <p>Background</p> <p>Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association between the use of antimicrobials and acquired antimicrobial resistance has highlighted the need for rational pharmacotherapy of common infections in general practice.</p> <p>Methods</p> <p>Management of urinary tract infections in general practice was studied prospectively over 8 weeks. Patients presenting with suspected UTI submitted a urine sample and were enrolled with an opt-out methodology. Data were collected on demographic variables, previous antimicrobial use and urine samples. Appropriateness of different treatment scenarios was assessed by comparing treatment with the laboratory report of the urine sample.</p> <p>Results</p> <p>A total of 22 practices participated in the study and included 866 patients. Bacteriuria was established for 21% of the patients, pyuria without bacteriuria for 9% and 70% showed no laboratory evidence of UTI. An antimicrobial agent was prescribed to 56% (481) of the patients, of whom 33% had an isolate, 11% with pyuria only and 56% without laboratory evidence of UTI. When taking all patients into account, 14% patients had an isolate identified and were prescribed an antimicrobial to which the isolate was susceptible. The agents most commonly prescribed for UTI were co-amoxyclav (33%), trimethoprim (26%) and fluoroquinolones (17%). Variation between practices in antimicrobial prescribing as well as in their preference for certain antimicrobials, was observed. Treatment as prescribed by the GP was interpreted as appropriate for 55% of the patients. Three different treatment scenarios were simulated, i.e. if all patients who received an antimicrobial were treated with nitrofurantoin, trimethoprim or ciprofloxacin only. Treatment as prescribed by the GP was no more effective than treatment with nitrofurantoin for all patients given an antimicrobial or treatment with ciprofloxacin in all patients. Prescribing cost was lower for nitrofurantoin. Empirical treatment of all patients with trimethoprim only was less effective due to the higher resistance levels.</p> <p>Conclusions</p> <p>There appears to be considerable scope to reduce the frequency and increase the quality of antimicrobial prescribing for patients with suspected UTI.</p
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