1,179 research outputs found
Tuning ultrafast electron thermalization pathways in a van der Waals heterostructure
Ultrafast electron thermalization - the process leading to Auger
recombination, carrier multiplication via impact ionization and hot carrier
luminescence - occurs when optically excited electrons in a material undergo
rapid electron-electron scattering to redistribute excess energy and reach
electronic thermal equilibrium. Due to extremely short time and length scales,
the measurement and manipulation of electron thermalization in nanoscale
devices remains challenging even with the most advanced ultrafast laser
techniques. Here, we overcome this challenge by leveraging the atomic thinness
of two-dimensional van der Waals (vdW) materials in order to introduce a highly
tunable electron transfer pathway that directly competes with electron
thermalization. We realize this scheme in a graphene-boron nitride-graphene
(G-BN-G) vdW heterostructure, through which optically excited carriers are
transported from one graphene layer to the other. By applying an interlayer
bias voltage or varying the excitation photon energy, interlayer carrier
transport can be controlled to occur faster or slower than the intralayer
scattering events, thus effectively tuning the electron thermalization pathways
in graphene. Our findings, which demonstrate a novel means to probe and
directly modulate electron energy transport in nanoscale materials, represent
an important step toward designing and implementing novel optoelectronic and
energy-harvesting devices with tailored microscopic properties.Comment: Accepted to Nature Physic
Ballistic Josephson junctions in edge-contacted graphene
Hybrid graphene-superconductor devices have attracted much attention since
the early days of graphene research. So far, these studies have been limited to
the case of diffusive transport through graphene with poorly defined and modest
quality graphene-superconductor interfaces, usually combined with small
critical magnetic fields of the superconducting electrodes. Here we report
graphene based Josephson junctions with one-dimensional edge contacts of
Molybdenum Rhenium. The contacts exhibit a well defined, transparent interface
to the graphene, have a critical magnetic field of 8 Tesla at 4 Kelvin and the
graphene has a high quality due to its encapsulation in hexagonal boron
nitride. This allows us to study and exploit graphene Josephson junctions in a
new regime, characterized by ballistic transport. We find that the critical
current oscillates with the carrier density due to phase coherent interference
of the electrons and holes that carry the supercurrent caused by the formation
of a Fabry-P\'{e}rot cavity. Furthermore, relatively large supercurrents are
observed over unprecedented long distances of up to 1.5 m. Finally, in the
quantum Hall regime we observe broken symmetry states while the contacts remain
superconducting. These achievements open up new avenues to exploit the Dirac
nature of graphene in interaction with the superconducting state.Comment: Updated version after peer review. Includes supplementary material
and ancillary file with source code for tight binding simulation
Lipoprotein(a) and inflammation in patients with atrial fibrillation after electrical cardioversion
<p>Abstract</p> <p>Background</p> <p>Recently few studies tried to confirm the association between AF and lipoprotein(a) (Lp(a)), however the results remained conflicted. In present study we evaluated the possible interaction between Lp(a), inflammatory state and echocardiographic characteristics in patients after successful electrical cardioversion (EC) of persistent AF. We also tried to investigate the role of Lp(a) as a possible prognostic factor for AF recurrence after successful EC.</p> <p>Results</p> <p>Data of 79 patients admitted due to planned EC was analyzed. After successful procedure patients were monitored for 2 years. For analytical purposes patients were divided in two groups according to AF recurrence. There was no significant difference between Lp(a) levels in both groups. We also didn't find any positive correlation between Lp(a) and CRP levels, as well as between Lp(a) levels and left atrium diameter. For logistic and survival analysis optimal cut-off value of Lp(a) â„ 0.32 (upper quartile) was used. In logistic regression model with AF recurrence as dependent variable Lp(a) didn't show any statistically significant association with AF recurrence. Survival analysis showed slightly higher AF recurrence rate in group with higher Lp(a) levels but not to the level of statistical significance (log rank test, <it>p </it>= 0.62).</p> <p>Conclusions</p> <p>We weren't able to confirm the association between Lp(a) levels and AF recurrence, inflammation and left atrium diameter in patients after successful EC of persistent AF. Further studies are needed to elucidate the role of Lp(a) in this clinical setting.</p
How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?
This work was financially support by a Marie Curie Initial Training Network grant, âUnderstanding the evolutionary origin of biological diversityâ (ITN-2008â213780 SPECIATION), grants from the Academy of Finland to A.H. (project 132619) and M.K. (projects 268214 and 272927), a grant from NERC, UK to M.G.R. (grant NE/J020818/1), and NERC, UK PhD studentship to D.J.P. (NE/I528634/1).For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace changes in gene expression during cold acclimation that lead to an increase in cold tolerance. We used an RNA-Seq approach to investigate this in two species of the Drosophila virilis group. We found that the majority of genes that are differentially expressed during cold acclimation differ between the two species. Despite this, the biological processes associated with the differentially expressed genes were broadly similar in the two species. These included: metabolism, cell membrane composition, and circadian rhythms, which are largely consistent with previous work on cold acclimation/cold tolerance. In addition, we also found evidence of the involvement of the rhodopsin pathway in cold acclimation, a pathway that has been recently linked to thermotaxis. Interestingly, we found no evidence of differential expression of stress genes implying that long-term cold acclimation and short-term stress response may have a different physiological basis.PostprintPeer reviewe
Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists
PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its translational validity. METHODS: A systematic review identified available evidence and was used to perform meta-analyses. RESULTS: Of 182 potentially relevant publications, 115 reported cisplatin-induced emesis in ferrets and 68 were included in the analysis. The majority (n = 53) used a 10 mg kg(â1) dose to induce acute emesis, which peaked after 2 h. More recent studies (n = 11) also used 5 mg kg(â1), which induced a biphasic response peaking at 12 h and 48 h. Overall, 5-HT(3) receptor antagonists reduced cisplatin (5 mg kg(â1)) emesis by 68% (45â91%) during the acute phase (day 1) and by 67% (48â86%) and 53% (38â68%, all P < 0.001), during the delayed phase (days 2, 3). In an analysis focused on the acute phase, the efficacy of ondansetron was dependent on the dosage and observation period but not on the dose of cisplatin. CONCLUSION: Our analysis enabled novel findings to be extracted from the literature including factors which may impact on the applicability of preclinical results to humans. It reveals that the efficacy of ondansetron is similar against low and high doses of cisplatin. Additionally, we showed that 5-HT(3) receptor antagonists have a similar efficacy during acute and delayed emesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret
Some Like It Fat: Comparative Ultrastructure of the Embryo in Two Demosponges of the Genus Mycale (Order Poecilosclerida) from Antarctica and the Caribbean
0000-0002-7993-1523© 2015 Riesgo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License [4.0], which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article
Ablation of Mrds1/Ofcc1 Induces Hyper-Îł-Glutamyl Transpeptidasemia without Abnormal Head Development and Schizophrenia-Relevant Behaviors in Mice
Mutations in the Opo gene result in eye malformation in medaka fish. The human ortholog of this gene, MRDS1/OFCC1, is a potentially causal gene for orofacial cleft, as well as a susceptibility gene for schizophrenia, a devastating mental illness. Based on this evidence, we hypothesized that this gene could perform crucial functions in the development of head and brain structures in vertebrates. To test this hypothesis, we created Mrds1/Ofcc1-null mice. Mice were examined thoroughly using an abnormality screening system referred to as âthe Japan Mouse Clinicâ. No malformations of the head structure, eye or other parts of the body were apparent in these knockout mice. However, the mutant mice showed a marked increase in serum Îł-glutamyl transpeptidase (GGT), a marker for liver damage, but no abnormalities in other liver-related measurements. We also performed a family-based association study on the gene in schizophrenia samples of Japanese origin. We found five single nucleotide polymorphisms (SNPs) located across the gene that showed significant transmission distortion, supporting a prior report of association in a Caucasian cohort. However, the knockout mice showed no behavioral phenotypes relevant to schizophrenia. In conclusion, disruption of the Mrds1/Ofcc1 gene elicits asymptomatic hyper-Îł-glutamyl-transpeptidasemia in mice. However, there were no phenotypes to support a role for the gene in the development of eye and craniofacial structures in vertebrates. These results prompt further examination of the gene, including its putative contribution to hyper-Îł-glutamyl transpeptidasemia and schizophrenia
Four-electron deoxygenative reductive coupling of carbon monoxide at a single metal site
Carbon dioxide is the ultimate source of the fossil fuels that are both central to modern life and problematic: their use increases atmospheric levels of greenhouse gases, and their availability is geopolitically constrained. Using carbon dioxide as a feedstock to produce synthetic fuels might, in principle, alleviate these concerns. Although many homogeneous and heterogeneous catalysts convert carbon dioxide to carbon monoxide, further deoxygenative coupling of carbon monoxide to generate useful multicarbon products is challenging. Molybdenum and vanadium nitrogenases are capable of converting carbon monoxide into hydrocarbons under mild conditions, using discrete electron and proton sources. Electrocatalytic reduction of carbon monoxide on copper catalysts also uses a combination of electrons and protons, while the industrial FischerâTropsch process uses dihydrogen as a combined source of electrons and electrophiles for carbon monoxide coupling at high temperatures and pressures6. However, these enzymatic and heterogeneous systems are difficult to probe mechanistically. Molecular catalysts have been studied extensively to investigate the elementary steps by which carbon monoxide is deoxygenated and coupled, but a single metal site that can efficiently induce the required scission of carbonâoxygen bonds and generate carbonâcarbon bonds has not yet been documented. Here we describe a molybdenum compound, supported by a terphenylâdiphosphine ligand, that activates and cleaves the strong carbonâoxygen bond of carbon monoxide, enacts carbonâcarbon coupling, and spontaneously dissociates the resulting fragment. This complex four-electron transformation is enabled by the terphenylâdiphosphine ligand, which acts as an electron reservoir and exhibits the coordinative flexibility needed to stabilize the different intermediates involved in the overall reaction sequence. We anticipate that these design elements might help in the development of efficient catalysts for converting carbon monoxide to chemical fuels, and should prove useful in the broader context of performing complex multi-electron transformations at a single metal site
Extraordinary carrier multiplication gated by a picosecond electric field pulse
The study of carrier multiplication has become an essential part of many-body physics and materials science as this multiplication directly affects nonlinear transport phenomena, and has a key role in designing efficient solar cells and electroluminescent emitters and highly sensitive photon detectors. Here we show that a 1-MVcmâ1 electric field of a terahertz pulse, unlike a DC bias, can generate a substantial number of electronâhole pairs, forming excitons that emit near-infrared luminescence. The bright luminescence associated with carrier multiplication suggests that carriers coherently driven by a strong electric field can efficiently gain enough kinetic energy to induce a series of impact ionizations that can increase the number of carriers by about three orders of magnitude on the picosecond time scale
Genome Fragmentation Is Not Confined to the Peridinin Plastid in Dinoflagellates
When plastids are transferred between eukaryote lineages through series of endosymbiosis, their environment changes dramatically. Comparison of dinoflagellate plastids that originated from different algal groups has revealed convergent evolution, suggesting that the host environment mainly influences the evolution of the newly acquired organelle. Recently the genome from the anomalously pigmented dinoflagellate Karlodinium veneficum plastid was uncovered as a conventional chromosome. To determine if this haptophyte-derived plastid contains additional chromosomal fragments that resemble the mini-circles of the peridin-containing plastids, we have investigated its genome by in-depth sequencing using 454 pyrosequencing technology, PCR and clone library analysis. Sequence analyses show several genes with significantly higher copy numbers than present in the chromosome. These genes are most likely extrachromosomal fragments, and the ones with highest copy numbers include genes encoding the chaperone DnaK(Hsp70), the rubisco large subunit (rbcL), and two tRNAs (trnE and trnM). In addition, some photosystem genes such as psaB, psaA, psbB and psbD are overrepresented. Most of the dnaK and rbcL sequences are found as shortened or fragmented gene sequences, typically missing the 3âČ-terminal portion. Both dnaK and rbcL are associated with a common sequence element consisting of about 120 bp of highly conserved AT-rich sequence followed by a trnE gene, possibly serving as a control region. Decatenation assays and Southern blot analysis indicate that the extrachromosomal plastid sequences do not have the same organization or lengths as the minicircles of the peridinin dinoflagellates. The fragmentation of the haptophyte-derived plastid genome K. veneficum suggests that it is likely a sign of a host-driven process shaping the plastid genomes of dinoflagellates
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