488 research outputs found
Scaling up kangaroo mother care in South Africa: 'on-site' versus 'off-site' educational facilitation
Background Scaling up the implementation of new health care interventions can be challenging and demand intensive training or retraining of health workers. This paper reports on the results of testing the effectiveness of two different kinds of face-to-face facilitation used in conjunction with a well-designed educational package in the scaling up of kangaroo mother care. Methods : Thirty-six hospitals in the Provinces of Gauteng and Mpumalanga in South Africa were targeted to implement kangaroo mother care and participated in the trial. The hospitals were paired with respect to their geographical location and annual number of births. One hospital in each pair was randomly allocated to receive either 'on-site' facilitation (Group A) or 'off-site' facilitation (Group B). Hospitals in Group A received two on-site visits, whereas delegates from hospitals in Group B attended one off-site, 'hands-on' workshop at a training hospital. All hospitals were evaluated during a site visit six to eight months after attending an introductory workshop and were scored by means of an existing progress-monitoring tool with a scoring scale of 0-30. Successful implementation was regarded as demonstrating evidence of practice (score >10) during the site visit. Results : There was no significant difference between the scores of Groups A and B (p = 0.633). Fifteen hospitals in Group A and 16 in Group B demonstrated evidence of practice. The median score for Group A was 16.52 (range 00.00-23.79) and that for Group B 14.76 (range 07.50-23.29). Conclusion : A previous trial illustrated that the implementation of a new health care intervention could be scaled up by using a carefully designed educational package, combined with face-to-face facilitation by respected resource persons. This study demonstrated that the site of facilitation, either on site or at a centre of excellence, did not influence the ability of a hospital to implement KMC. The choice of outreach strategy should be guided by local circumstances, cost and the availability of skilled facilitators
From Necklace Quivers to the F-theorem, Operator Counting, and T(U(N))
The matrix model of Kapustin, Willett, and Yaakov is a powerful tool for
exploring the properties of strongly interacting superconformal Chern-Simons
theories in 2+1 dimensions. In this paper, we use this matrix model to study
necklace quiver gauge theories with {\cal N}=3 supersymmetry and U(N)^d gauge
groups in the limit of large N. In its simplest application, the matrix model
computes the free energy of the gauge theory on S^3. The conjectured F-theorem
states that this quantity should decrease under renormalization group flow. We
show that for a simple class of such flows, the F-theorem holds for our
necklace theories. We also provide a relationship between matrix model
eigenvalue distributions and numbers of chiral operators that we conjecture
holds more generally. Through the AdS/CFT correspondence, there is therefore a
natural dual geometric interpretation of the matrix model saddle point in terms
of volumes of 7-d tri-Sasaki Einstein spaces and some of their 5-d
submanifolds. As a final bonus, our analysis gives us the partition function of
the T(U(N)) theory on S^3.Comment: 3 figures, 41 pages; v2 minor improvements, refs adde
Holographic zero sound at finite temperature in the Sakai-Sugimoto model
In this paper, we study the fate of the holographic zero sound mode at finite
temperature and non-zero baryon density in the deconfined phase of the
Sakai-Sugimoto model of holographic QCD. We establish the existence of such a
mode for a wide range of temperatures and investigate the dispersion relation,
quasi-normal modes, and spectral functions of the collective excitations in
four different regimes, namely, the collisionless quantum, collisionless
thermal, and two distinct hydrodynamic regimes. For sufficiently high
temperatures, the zero sound completely disappears, and the low energy physics
is dominated by an emergent diffusive mode. We compare our findings to
Landau-Fermi liquid theory and to other holographic models.Comment: 1+24 pages, 19 figures, PDFTeX, v2: some comments and references
added, v3: some clarifications relating to the different regimes added,
matches version accepted for publication in JHEP, v4: corrected typo in eq.
(3.18
BPS dyons and Hesse flow
We revisit BPS solutions to classical N=2 low energy effective gauge
theories. It is shown that the BPS equations can be solved in full generality
by the introduction of a Hesse potential, a symplectic analog of the
holomorphic prepotential. We explain how for non-spherically symmetric,
non-mutually local solutions, the notion of attractor flow generalizes to
gradient flow with respect to the Hesse potential. Furthermore we show that in
general there is a non-trivial magnetic complement to this flow equation that
is sourced by the momentum current in the solution.Comment: 25 pages, references adde
Holographic Hadrons in a Confining Finite Density Medium
We study a sector of the hadron spectrum in the presence of finite baryon
density. We use a non-supersymmetric gravity dual to a confining guage theory
which exhibits a running dilaton. The interaction of mesons with the finite
density medium is encoded in the dual theory by a force balancing between
flavor D7-branes and a baryon vertex provided by a wrapped D5-brane. When the
current quark mass m_q is sufficiently large, the meson mass reduces,
exhibiting an interesting spectral flow as we increase the baryon density while
it has a more complicated behaviour for very small m_q.Comment: 34 pages, 20 figures, errors for some figures are fixe
The prevalence and experience of oral diseases in Adelaide nursing home residents
The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Background: The twenty-first century will see the evolution of a population of dentate older Australians with dental needs very different from those of older adults in past years. This study provided comprehensive information concerning oral disease prevalence in older South Australian nursing home residents. Methods: This paper presents cross-sectional baseline results. Results: Most of the 224 residents, from seven randomly selected nursing homes, were functionally dependent, medically compromised, cognitively impaired and behaviourally difficult older adults who presented many complex challenges to carers and to dental professionals. Two-thirds (66 per cent) were edentulous with many dental problems and treatment needs. Dentate residents had a mean of 11.9 teeth present, higher than previously reported. The prevalence and experience of coronal and root caries and plaque accumulation was very high in dentate residents; especially males, those admitted more than three years previously, those who ate fewer food types and those who were severely cognitively impaired. These residents had more retained roots, decayed teeth and missing teeth, and fewer filled teeth when compared with data for community-dwelling older adults. Conclusions: This study highlighted the poor oral health status of these nursing home residents and the great impact of dementia on their high levels of oral diseases.JM Chalmers, C Hodge, JM Fuss, AJ Spencer, KD Carte
Understanding emotionally relevant situations in primary care dental practice: 1. Clinical situations and emotional responses
Background and aims. The stressful nature of dental practice is well established. Much less information is available on the coping strategies used by dentists and the emotions which underlie the stressful experience. Previous research has been almost exclusively questionnaire-based, limiting the range of emotions explored. This study used qualitative methods to explore the full extent of emotions and coping strategies associated with stressful events in primary dental practice.
Method. Semi-structured interviews were conducted with 20 dentists in Lincoln and the surrounding area. Verbatim transcriptions were analysed using thematic analysis.
Results. Participants reported a wide variety of stressful situations, consistent with the existing literature, which were associated with a diverse range of negative emotional responses including anxiety, anger and sadness. Dentists tended to have more difficulty identifying positive events and emotions. The designation of a situation as stressful or otherwise was dependent on the dentist's personal interpretation of the event. Data relating to the effects of stressors and the coping strategies used by dentists will be presented in subsequent papers.
Conclusion. The situations which dentists find difficult are accompanied by a diverse set of emotions, rather than omnipresent 'stress.' This has implications for stress management programmes for those in dental practic
Atmospheric oxygen regulation at low Proterozoic levels by incomplete oxidative weathering of sedimentary organic carbon
It is unclear why atmospheric oxygen remained trapped at low levels for more than 1.5 billion years following the Paleoproterozoic Great Oxidation Event. Here, we use models for erosion, weathering and biogeochemical cycling to show that this can be explained by the tectonic recycling of previously accumulated sedimentary organic carbon, combined with the oxygen sensitivity of oxidative weathering. Our results indicate a strong negative feedback regime when atmospheric oxygen concentration is of order pO2∼0.1 PAL (present atmospheric level), but that stability is lost at pO2<0.01 PAL. Within these limits, the carbonate carbon isotope (δ13C) record becomes insensitive to changes in organic carbon burial rate, due to counterbalancing changes in the weathering of isotopically light organic carbon. This can explain the lack of secular trend in the Precambrian δ13C record, and reopens the possibility that increased biological productivity and resultant organic carbon burial drove the Great Oxidation Event
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
The quest for new antimalarial drugs, especially those with novel modes of action, is essential in the face of emerging drug-resistant parasites. Here we describe a new chemical class of molecules, pyrazoleamides, with potent activity against human malaria parasites and showing remarkably rapid parasite clearance in an in vivo model. Investigations involving pyrazoleamide-resistant parasites, whole-genome sequencing and gene transfers reveal that mutations in two proteins, a calcium-dependent protein kinase (PfCDPK5) and a P-type cation-ATPase (PfATP4), are necessary to impart full resistance to these compounds. A pyrazoleamide compound causes a rapid disruption of Na+ regulation in blood-stage Plasmodium falciparum parasites. Similar effect on Na+ homeostasis was recently reported for spiroindolones, which are antimalarials of a chemical class quite distinct from pyrazoleamides. Our results reveal that disruption of Na+ homeostasis in malaria parasites is a promising mode of antimalarial action mediated by at least two distinct chemical classes
Whole genome sequencing reveals a 7 base-pair deletion in DMD exon 42 in a dog with muscular dystrophy
Dystrophin is a key cytoskeletal protein coded by the Duchenne muscular dystrophy (DMD) gene located on the X-chromosome. Truncating mutations in the DMD gene cause loss of dystrophin and the classical DMD clinical syndrome. Spontaneous DMD gene mutations and associated phenotypes occur in several other species. The mdx mouse model and the golden retriever muscular dystrophy (GRMD) canine model have been used extensively to study DMD disease pathogenesis and show efficacy and side effects of putative treatments. Certain DMD gene mutations in high-risk, the so-called hot spot areas can be particularly helpful in modeling molecular therapies. Identification of specific mutations has been greatly enhanced by new genomic methods. Whole genome, next generation sequencing (WGS) has been recently used to define DMD patient mutations, but has not been used in dystrophic dogs. A dystrophin-deficient Cavalier King Charles Spaniel (CKCS) dog was evaluated at the functional, histopathological, biochemical, and molecular level. The affected dog’s phenotype was compared to the previously reported canine dystrophinopathies. WGS was then used to detect a 7 base pair deletion in DMD exon 42 (c.6051-6057delTCTCAAT mRNA), predicting a frameshift in gene transcription and truncation of dystrophin protein translation. The deletion was confirmed with conventional PCR and Sanger sequencing. This mutation is in a secondary DMD gene hotspot area distinct from the one identified earlier at the 5′ donor splice site of intron 50 in the CKCS breed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00335-016-9675-2) contains supplementary material, which is available to authorized users
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