Bullous Fixed Drug Eruption Induced by Paracetamol: Report of a Pediatric Case

Drug eruptions are among the most common adverse drug reactions, affecting approximately 3% of hospitalized patients. A fixed drug eruption (FDE) is a distinct drug-induced reaction pattern that characteristically recurs at the same skin or mucosal site. We report a case of a 2-year-old girl with bullous FDE due to Tachipirina syrup, a preparation containing paracetamol, a commonly used nonsteroidal anti-inflammatory drug in Italy

Ultraviolet B and A irradiation induces fibromodulin expression in human fibroblasts in vitro

Ultraviolet (UV) radiation affects the extracellular matrix (ECM) of the human skin. The small leucine-rich repeat protein fibromodulin interacts with type I and II collagen fibrils, thereby affecting ECM assembly. The aim of this study was to evaluate whether short wave UV (UVB) or long wave UV (UVA) irradiation influences fibromodulin expression. Exponentially growing human fibroblasts (IMR-90 cells) were exposed to increasing doses of UVB (2.5-60 mJ/cm(2)) or UVA (0.5-10 J/cm(2)). After UV irradiation fibromodulin, p21 and GADD45 levels were evaluated as well as cell viability, reactive oxygen species formation (ROS) and DNA damage. We found that fibromodulin expression: (i) increased after UVB and UVA irradiation; (ii) was 10-fold higher after UVA (10 J/cm(2)) versus 5-fold with UVB (10 mJ/cm(2)); (iii) correlated with reactive oxygen species formation, particularly after UVA; and (iv) was linked to the DNA damage binding protein (DDB1) translocation in the nucleus, particularly after UVB. These results further suggest that the UV-induced fibromodulin increase could counteract the UV-induced connective tissue damage, promoting the assembly of new collagen fibrils

Kaolin protects olive fruits from Bactrocera oleae (Gmelin) infestations unaffecting olive oil quality

The efficacy of the processed kaolin “Surround WP” to control olive fruit fly, Bactrocera oleae Gmelin, field infestations was investigated in east Calabria. The preliminary results showed that fruit infestation levels were significantly reduced on kaolin-treated trees compared with untreated trees. The promising results of these experiments points to the feasibility of using particle film technology composed of a non-toxic material, to avoid olive fly damage as an alternative to the applications of rotenone in organic orchards. Finally, kaolin treatment unaffected the nutritional and sensory quality parameters of the corresponding virgin olive oils obtained by a laboratory scale olive mill, thus satisfying the present quality requirements

The 2014 Earthquake Model of the Middle East: seismogenic sources

The Earthquake Model of Middle East (EMME) project was carried out between 2010 and 2014 to provide a harmonized seismic hazard assessment without country border limitations. The result covers eleven countries: Afghanistan, Armenia, Azerbaijan, Cyprus, Georgia, Iran, Jordan, Lebanon, Pakistan, Syria and Turkey, which span one of the seismically most active regions on Earth in response to complex interactions between four major tectonic plates i.e. Africa, Arabia, India and Eurasia. Destructive earthquakes with great loss of life and property are frequent within this region, as exemplified by the recent events of Izmit (Turkey, 1999), Bam (Iran, 2003), Kashmir (Pakistan, 2005), Van (Turkey, 2011), and Hindu Kush (Afghanistan, 2015). We summarize multidisciplinary data (seismicity, geology, and tectonics) compiled and used to characterize the spatial and temporal distribution of earthquakes over the investigated region. We describe the development process of the model including the delineation of seismogenic sources and the description of methods and parameters of earthquake recurrence models, all representing the current state of knowledge and practice in seismic hazard assessment. The resulting seismogenic source model includes seismic sources defined by geological evidence and active tectonic findings correlated with measured seismicity patterns. A total of 234 area sources fully cross-border-harmonized are combined with 778 seismically active faults along with background-smoothed seismicity. Recorded seismicity (both historical and instrumental) provides the input to estimate rates of earthquakes for area sources and background seismicity while geologic slip-rates are used to characterize fault-specific earthquake recurrences. Ultimately, alternative models of intrinsic uncertainties of data, procedures and models are considered when used for calculation of the seismic hazard. At variance to previous models of the EMME region, we provide a homogeneous seismic source model representing a consistent basis for the next generation of seismic hazard models within the region.Published3465-34966T. Studi di pericolosità sismica e da maremotoJCR Journa

Investigar en Trabajo Social: diferentes experiencias como pasantes de investigación

El presente trabajo se propone compartir tres experiencias de investigación llevadas a cabo por estudiantes (ahora licenciadas) en la Facultad de Trabajo Social de la Universidad Nacional de La Plata, en diferentes proyectos de investigación. Dos de las experiencias de pasantías se enmarcaron en el proyecto de investigación “Seguridad, Violencia y Derechos Humanos. Un estudio de las representaciones sociales en jóvenes y policías”1. La otra pasantía se inserta en el proyecto “Disputas en el espacio público: cultura, política y desigualdades socio-urbanas”2. A su vez, dos de nosotras continuamos nuestro proceso de aprendizaje del oficio de investigar a través de dos becas CIN en el marco de los proyectos de investigación acreditados, mencionados anteriormente. Haremos una breve mención respecto a esto. Por último, analizaremos las experiencias como pasantes de investigación a la luz de los aportes de distintos autores/as, haciendo hincapié principalmente en la comprensión de las competencias, habilidades y destrezas necesarias para desarrollar la práctica investigativa.Eje Teórico-metodológico en Trabajo Social-GT 27: Metodología y Trabajo Social.Facultad de Trabajo Socia

Comparison of HIV-1 Genotypic Resistance Test Interpretation Systems in Predicting Virological Outcomes Over Time

Background: Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. Methodology/Principal Findings: Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was available at the time of changing treatment with at least one follow-up viral load measurement. Genotypic susceptibility scores for the active regimens were calculated using scores defined by each interpretation system. Using logistic regression, we determined the association between the genotypic susceptibility score and proportion of TCEs having an undetectable viral load (<50 copies/ml) at 12 (8-16) weeks (2152 TCEs), 24 (16-32) weeks (2570 TCEs), and 48 (44-52) weeks (1083 TCEs). The Area under the ROC curve was calculated using a 10-fold cross-validation to compare the different interpretation systems regarding the sensitivity and specificity for predicting undetectable viral load. The mean genotypic susceptibility score of the systems was slightly smaller for HIVdb, with 1.92±1.17, compared to Rega and ANRS, with 2.22±1.09 and 2.23±1.05, respectively. However, similar odds ratio's were found for the association between each-unit increase in genotypic susceptibility score and undetectable viral load at week 12; 1.6 [95% confidence interval 1.5-1.7] for HIVdb, 1.7 [1.5-1.8] for ANRS, and 1.7 [1.9-1.6] for Rega. Odds ratio's increased over time, but remained comparable (odds ratio's ranging between 1.9-2.1 at 24 weeks and 1.9-2.

Prevalence of hepatic steatosis in patients with type 2 diabetes and response to glucose-lowering treatments. A multicenter retrospective study in Italian specialist care

Type 2 diabetes (T2D) is a risk factor for metabolic dysfunction-associated fatty liver disease (MAFLD), which is becoming the commonest cause of chronic liver disease worldwide. We estimated MAFLD prevalence among patients with T2D using the hepatic steatosis index (HSI) and validated it against liver ultrasound. We also examined whether glucose-lowering medications (GLM) beneficially affected HSI

Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study

Aims According to cardiovascular outcome trials, some sodium-glucose contransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real-world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP-1RA as second or a more advanced line of therapy. Materials and methods DARWIN-T2D was a retrospective multi-centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP-1RA (exenatide once weekly or liraglutide). Data were collected at baseline and at the first follow-up visit after 3 to 12 months. The primary endpoint was the proportion of patients achieving a simultaneous reduction in HbA1c, body weight and systolic blood pressure. To reduce confounding, we used multivariable adjustment (MVA) or propensity score matching (PSM). Results Totals of 473 patients initiating dapagliflozin and 336 patients initiating GLP-1RA were included. The two groups differed in age, diabetes duration, HbA1c, weight and concomitant medications. The median follow-up was 6 months in both groups. Using MVA or PSM, the primary endpoint was observed in 30% to 32% of patients, with no difference between groups. Simultaneous reduction of HbA1c, BP and SBP by specific threshold, as well as achievement of final goals, did not differ between groups. GLP-1RA reduced HbA1c by 0.3% more than the reduction achieved with dapagliflozin. Conclusion In routine specialist care, initiation of dapagliflozin can be as effective as initiation of a GLP-1RA for attainment of combined risk factor goals

Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management