Frustrated multiband superconductivity

We show that a clean multiband superconductor may display one or several phase transitions with increasing temperature from or to frustrated configurations of the relative phases of the superconducting order parameters. These transitions may occur when more than two bands are involved in the formation of the superconducting phase and when the number of repulsive interband interactions is odd. These transitions are signalled by slope changes in the temperature dependence of the superconducting gaps.Comment: 5 pages, 3 figure

Charge on the quantum dot in the presence of tunneling current

The calculation of the charge present in central region of the double barrier structure at non-equilibrium conditions is discussed. We propose here a simple method to calculate non equilibrium Green's functions which allows consistent calculations of retarded and distribution functions. To illustrate the approach we calculate the charge on the quantum dot coupled {\it via} tunnel barriers to two external leads having different chemical potentials $\mu_L$ and $\mu_R$. The obtained results have been compared with other approaches existing in the literature. They all agree in the equilibrium situation and the departures grow with increasing the difference $\mu_L-\mu_R$.Comment: 9 pages, 2 (.eps) figures, to be published in Solid State Commu

Prokineticin 2 Is a Target Gene of Proneural Basic Helix-Loop-Helix Factors for Olfactory Bulb Neurogenesis

Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors. Neurogenin 1 and MASH1 activate PK2 transcription by binding to E-box motifs on the PK2 promoter with the same set of E-boxes critical for another pair of bHLH factors, CLOCK and BMAL1, in the regulation of circadian clock. Our results establish PK2 as a common functional target gene for different bHLH transcriptional factors in mediating their respective functions

Developing a service user informed intervention to improve participation and ability to perform daily activities in primary Sjögren’s syndrome: a mixed-methods study protocol

Introduction: A significant proportion of patients with primary Sjögren’s syndrome (PSS) is functionally impaired and experience difficulties participating in various aspects of everyday life. There is currently no evidence of efficacy for non-pharmacological interventions aimed specifically at supporting the patients with PSS to improve their participation and ability to perform daily activities. This paper describes a research protocol for a mixed-methods study to develop an intervention to improve these outcomes. The protocol follows the Medical Research Council framework for complex interventions. Methods and analysis: We will use group concept mapping with the patients, adults who live with them and healthcare professionals to identify factors which prevent people with PSS from participating in daily life and performing daily activities. The factors will be prioritised by participants for importance and feasibility and will inform an intervention to be delivered within a National Health Service (NHS) setting. Evidence-based intervention techniques will be identified for the prioritised factors and combined into a deliverable intervention package. Key stakeholders will comment on the intervention content and mode of delivery through focus groups, and the data will be used to refine the intervention. The acceptability and feasibility of the refined intervention will be evaluated in a future study. Ethics and dissemination: The study has been approved by an NHS Research Ethics Committee, REC Reference: 13/NI/0190. The findings of this study will be disseminated in peer-reviewed journals and through presentation at national and international conferences. Trial registration number: UKCRN Study ID: 15939

CP violation in 5D Split Fermions Scenario

We give a new configuration of split fermion positions in one extra dimension with two different Yukawa coupling strengths for up-type, $h_u$, and down-type, $h_d$, quarks at $\frac{h_u}{h_d}=36.0$. The new configurations can give enough CP violating (CPV) phase for accommodating all currently observed CPV processes. Therefore, a 5D standard model with split fermions is viable. In addition to the standard CKM phase, new CPV sources involving Kaluza-Klein(KK) gauge bosons coupling which arise from the fact that unitary rotation which transforms weak eigenstates into their mass eigenstates only holds for the zero modes which are the SM fields and not for the KK excitations. We have examined the physics of kaon, neutron, and $B/D$ mesons and found the most stringent bound on the size $R$ of the extra dimension comes from $|\epsilon_K|$. Moreover, it depends sensitively on the width, $\sigma$, of the Gaussian wavefunction in the extra dimension used to describe of the fermions. When $\sigma/R \ll 1$, the constraint will be lifted due to GIM suppression on the flavor changing neutral current(FCNC) and CPV couplings.Comment: 24 pages, 8 figure

Mutual-Chern-Simons effective theory of doped antiferromagnets

A mutual-Chern-Simons Lagrangian is derived as a minimal field theory description of the phase-string model for doped antiferromagnets. Such an effective Lagrangian is shown to retain the full symmetries of parity, time-reversal, and global SU(2) spin rotation, in contrast to conventional Chern-Simons theories where first two symmetries are usually broken. Two ordered phases, i.e., antiferromagnetic and superconducting states, are found at low temperatures as characterized by dual Meissner effects and dual flux quantization conditions due to the mutual-Chern-Simons gauge structure. A dual confinement in charge/spin degrees of freedom occurs such that no true spin-charge separation is present in these ordered phases, but the spin-charge separation/deconfinement serves as a driving force in the unconventional phase transitions of these ordered states to disordered states.Comment: 16 pages, 2 figures; published versio

Numerical analyses of the nonequilibrium electron transport through the Kondo impurity beside the Toulouse point

Nonequilibrium electron transport through the Kondo impurity is investigated numerically for the system with twenty conduction-electron levels. The electron current under finite voltage drop is calculated in terms of the `conductance viewed as transmission' picture proposed by Landauer. Here, we take into account the full transmission processes of both the many-body correlation and the hybridization amplitude up to infinite order. Our results demonstrate, for instance, how the exact solution of the differential conductance by Schiller and Hershfield obtained at the Toulouse point becomes deformed by more realistic interactions. The differential-conductance-peak height is suppressed below e^2/h with the width hardly changed through reducing the Kondo coupling from the Toulouse point, whereas it is kept unchanged by further increase of the coupling. We calculated the nonequilibrium local Green function as well. This clarifies the spectral property of the Kondo impurity driven far from equilibrium

Density-metric unimodular gravity: vacuum maximal symmetry

We have investigated the vacuum maximally symmetric solutions of recently proposed density-metric unimodular gravity theory,the results are widely different from inflationary senario.The exponential dependence on time in deSitter space is substiuted by a power law. Open space-times with non-zero cosmological constant are excluded in this theoryComment: 15 pages, no figures,stability section omitte

Drosophila Proliferating Cell Nuclear Antigen - Structural and Functional Homology with Its Mammalian Counterpart

A protein with an apparent mass of 36 kDa was purified from Drosophila melanogaster embryos using a protocol developed for the purification of proliferating cell nuclear antigen (PCNA) from human 293 cells. The Drosophila protein comigrated with human PCNA on one-dimensional sodium dodecyl sulfate-polyacrylamide gels and cross-reacted with monoclonal anti-rabbit PCNA antibodies. NH2-terminal amino acid sequence analysis revealed that the putative Drosophila PCNA was highly homologous to human PCNA. Of the first 22 amino acids, 16 were identical, and 4 of the remaining 6 were changed conservatively. Results of total amino acid analysis were also consistent with a high degree of similarity between Drosophila PCNA and human PCNA. Functional analysis using the reconstituted simian virus 40 in vitro DNA replication system demonstrated that Drosophila PCNA could substitute, albeit with reduced efficiency, for human PCNA in stimulating simian virus 40 DNA synthesis. Affinity-purified anti-Drosophila PCNA antibodies cross-reacted with human PCNA and were able to recognize specifically Drosophila PCNA both on crude homogenate immunoblots and by indirect immunofluorescence analysis of proliferating cells in larval tissues in situ. These antibodies thus promise to be useful probes for the study of cell proliferation in this rapidly developing organism