Getting better acquainted with Auditory Voice Hallucinations (AVHs): A need for clinical and social change

The phenomenon of hearing voices (AVHs) is very much a subject of current scientific interest, both clinically1 and socially. For a long time, auditory hallucinations—perceiving sounds without external stimuli (David, 2004)—were considered an obvious sign of schizophrenic or psychotic psychopathology (Goodwin et al., 1971; Larøi et al., 2012), but these days such an association is no longer taken for granted. Various recent studies in the areas of psychology, psychiatry, and neuroscience have brought a renewal of interest in AVHs. First of all, the move beyond Kraepelinian logic (van Os, 2009; Fusar-Poli et al., 2014) has led us to see AVHs as a phenomenon in their own right, and not just a characteristic of schizophrenia (Fernyhough, 2004). Furthermore, a number of studies in imaging techniques have allowed us to study the phenomenon live, as it occurs, collecting various new data (Shergill et al., 2000). On the other hand, psychological studies with attempts at modeling, have boosted the idea that AVHs are linked to the linguistic and verbal qualities of the subject, thus reducing the association between voice hallucinations and signs of pathology (Johns and van Os, 2001; Pearson et al., 2001; Stanghellini and Cutting, 2003). Other researchers have theorized that hearing voices is a different manifestation of self-awareness (Salvini and Bottini, 2011; Salvini and Quarato, 2011). Even DSM-5 has modified the importance it attaches to hallucinations, in fact although the 4th edition diagnosed “schizophrenia” simply on the basis of the symptom “hallucinations,” in the new edition hallucinations on their own are not considered a sufficient symptom to diagnose the specter of schizophrenia” (American Psychiatric Association, 2013). Many of those suffering from this condition are not under treatment and are not diagnosable in psychopathological terms, which asks ever more questions of health professionals (Iudici, 2015), and which brings with it the risk that the phenomenon of hearing voices may be considered pathological because of a lack of understanding of the problem. One direct implication of this risk concerns non-psychotic and non-schizophrenic hearers of voices who are afraid of being considered mad or disturbed, who very often live in fear for years without talking about it with anyone, although realizing that hearing voices causes no general maladjustment in their lives (Andrew et al., 2008). In the long term this can lead to feelings of alarm in some of them, and when such situations result in a visit to a clinic or a psychiatrist, there are often “suffering and conflicted confessions” about such experiences, especially by people who have never had psychiatric experience (Iudici and Gagliardo Corsi, 2017). These people consequently do not have appropriate information to help them understand their experiences (Faccio et al., 2013). This fact raises further doubts about the direct juxtaposition of auditory hallucinations and diagnoses of mental disturbance, and consequently our interest is in sensitizing clinicians to a broader interpretation of the phenomenon than the traditional view, highlighting the importance of considering more perspectives

Landscape and City during Fascism: Enrico del Debbio’s Foro Mussolini

Beiträge zum Symposium „Urban design and dictatorship in the 20th century: Italy, Portugal, the Soviet Union, Spain and Germany. History and Historiography“. Weimar, 21.-22. November 2013For decades in Germany, historical research on dictatorial urban design in the first half of the 20th century focused on the National Socialist period. Studies on the urban design practices of other dictatorships remained an exception. This has changed. Meanwhile, the urban production practices of the Mussolini, Stalin, Salazar, Hitler and Franco dictatorships have become the subject of comprehensive research projects. Recently, a research group that studies dictatorial urban design in 20th century Europe has emerged at the Bauhaus-Institut für Geschichte und Theorie der Architektur und der Planung. The group is already able to refer to various research results. Part of the research group’s self-conception is the assumption that the urban design practices of the named dictatorships can only be properly understood from a European perspective. The dictatorships influenced one another substantially. Furthermore, the specificities of the practices of each dictatorship can only be discerned if one can compare them to those of the other dictatorships. This approach requires strict adherence to the research methods of planning history and urban design theory. Meanwhile, these methods must be opened to include those of general historical studies. With this symposium, the research group aims to further qualify this European perspective. The aim is to pursue an inventory of the various national historiographies on the topic of “urban design and dictatorship”. This inventory should offer an overview on the general national level of historical research on urban design as well as on the level of particular urban design projects, persons or topics. The symposium took place in Weimar, November 21-22, 2013. It was organized by Harald Bodenschatz, Piero Sassi and Max Welch Guerra and funded by the DAAD (German Academic Exchange Service)

Atenção a saúde dos discentes estrangeiros nas universidades com vocação internacional – demandas, políticas e práticas e perspectivas para fruição e acesso do direito à saúde dos ingressantes não nacionais na UNILA e UNILAB

Anais do VI Encontro de Iniciação Científica e II Encontro Anual de Iniciação ao Desenvolvimento Tecnológico e Inovação – EICTI 2017 - 04 a 06 de outubro de 2017 - temática Ciências Sociais AplicadasA proposta em tela busca conhecer e evidenciar como e de que forma se deu o planejamento e implementação de políticas e práticas de atenção à saúde dos discentes estrangeiros, propondo identificar alterações de cunho ético-político e institucionais a partir do processo de implantação das universidades federais com vocação para a integração internacional, Unila e Unilab, localizadas no Paraná e no Ceará respectivamente. Destaca-se que essa pesquisa tem relevância social, política e científica considerando que busca entender as particularidades na atenção à saúde dos discentes estrangeiros, propondo uma análise teórica de leis, pactos, protocolos e acordos – do local ao global – em relação à atenção em saúde pública e seus condicionantes no âmbito do Sistema Único de Saúde brasileiro. Além de apontar novas perspectivas de análise e atuação para os gestores de saúde dos municípios e das unidades de ensino nas cidades sedes de universidadesUniversidade Federal da Integração Latino-Americana (Unila); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação Araucária; Parque Tecnológico Itaipu (PTI) e Companhia de Saneamento do Paraná (SANEPAR

Exposure-Tolerant Imaging Solution forCultural Heritage Monitoring

This paper describes a simple and cheap solution specifically designed for monitoring the degradation of thin coatings employed for metal protection. The proposed solution employs a commercial photocamera and a frequency-domain-based approach that is capable of highlighting the surface uniformity changes due to initial corrosion. Even though the proposed solution is specifically designed to monitor the long-time performance of protective coatings employed for the restoration of silver artifacts, it can be successfully used also for assessing the conservation state of other ancient metallic works of art. The proposed solution is made tolerant to exposure changes by using a procedure for sensor nonlinearity identification and correction, does not require a precise lighting control, and employs only free open-source software, so that its overall cost is very low and can be used also by not specifically trained operator

Carbohydrate polymers as controlled release devices for pesticides

Controlled release technology addresses problems associated with excessive use of toxic agricultural chemicals. This paper reviews the studies on the use of carbohydrate polymers as controlled release matrices for pesticides. Alginates, starch and its derivatives, chitosan, carboxymethylcellulose and ethylcellulose are some of the natural polymers discussed in this review. The advantages and disadvantages of these polymeric systems as well as the factors that affect pesticide release are presented. A discussion on the polymers’ encapsulation efficiency and release profile is also included, which will aid future researchers in identifying the suitable formulation for controlled release of pesticides. Combination of two polymers, incorporation of sorbents into polymer matrices, and modification of polymer systems are some of the strategies also discussed herein. Recent trends in this area of research include nanoformulation, nanoencapsulation, and the development of polymeric systems with dual properties such as controlled release with photo-protective property and the attract-and-kill strategy. Cytotoxicity studies are being conducted to address safety issues of pesticide handlers as well as to determine the toxicity of the formulation to non-target organisms such as the plant itself

Coverage and Deployment Analysis of Narrowband Internet of Things in the Wild

Narrowband Internet of Things (NB-IoT) is gaining momentum as a promising technology for massive Machine Type Communication (mMTC). Given that its deployment is rapidly progressing worldwide, measurement campaigns and performance analyses are needed to better understand the system and move toward its enhancement. With this aim, this paper presents a large scale measurement campaign and empirical analysis of NB-IoT on operational networks, and discloses valuable insights in terms of deployment strategies and radio coverage performance. The reported results also serve as examples showing the potential usage of the collected dataset, which we make open-source along with a lightweight data visualization platform.Comment: Accepted for publication in IEEE Communications Magazine (Internet of Things and Sensor Networks Series

DOMINO PROJECT GUIDELINES FOR EXPERIMENTAL PRACTICE

The aim of this handbook of experimental guidelines is to level out analyses run during the "Domino project" on practices for sustainable management of organic apple orchard and vineyard in field condition

Early loss of blood-brain barrier integrity precedes NOX2 elevation in the prefrontal cortex of an animal model of psychosis

The social isolation rearing of young adult rats is a model of psychosocial stress and provides a nonpharmacological tool to study alterations reminiscent of symptoms seen in psychosis. We have previously demonstrated that social isolation in rats leads to increased oxidative stress and to cerebral NOX2 elevations. Here, we investigated early alterations in mRNA expression leading to increased NOX2 in the brain. Rats were exposed to a short period of social isolation (1 week) and real-time polymerase chain reaction (PCR) for mRNA expression of genes involved in blood-brain barrier (BBB) formation and integrity (ORLs, Vof 21 and Vof 16, Leng8, Vnr1, and Trank 1 genes) was performed. Real-time PCR experiments, immunohistochemistry, and Western blotting analysis showed an increased expression of these genes and related proteins in isolated rats with respect to control animals. The expression of specific markers of BBB integrity, such as matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 9 (MMP9), occludin 1, and plasmalemmal vesicle associated protein-1 (PV-1), was also significantly altered after 1 week of social isolation. BBB permeability, evaluated by quantification of Evans blue dye extravasation, as well as interstitial fluid, was significantly increased in rats isolated for 1 week with respect to controls. Isolation-induced BBB disruption was also accompanied by a significant increase of Interleukin 6 (IL-6) expression. Conversely, no differences in NOX2 levels were detected at this time point. Our study demonstrates that BBB disruption precedes NOX2 elevations in the brain. These results provide new insights in the interplay of mechanisms linking psychosocial stress to early oxidative stress in the brain, disruption of the BBB, and the development of mental disorders