112 research outputs found

    Enhancing Scholarly Publications: Developing Hybrid Monographs in the Humanities and Social Sciences

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    Enhancing publications has a long history but is gaining acceleration as authors and publishers explore electronic tablets as devices for dissemination and presentation. Enhancement of scholarly publications, in contrast, more often takes place in a Web environment and is coupled with presentation of supplementary materials related to research. The approach to enhancing scholarly publications presented in this article goes a step further and involves the interlinking of the “objects” of a document: datasets, supplementary materials, secondary analyses, and post-publication interventions. This approach connects the user-centricity of Web 2.0 with the Semantic Web. It aims at facilitating long-term content structure through standardized formats intended to improve interoperability between concepts and terms within and across knowledge domains. We explored this conception of enhancement on a small set of books prepared for traditional academic publishers. While the project was primarily an exercise in development, the conclusion section of the article reflects on areas where conceptual and empirical studies could be initiated to complement this new direction in scholarly publishing.FSW - CWTS - Ou

    Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

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    Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

    Recent PhD dissertations in cultural and communication studies

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    Contains fulltext : 29617-OA.pdf (publisher's version ) (Open Access

    Researching audiences : ,2005 0-340-76275-6

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    Contains fulltext : 54816.pdf (publisher's version ) (Open Access)K. Schøder Researching audiences : ,2005 0-340-76275-

    Community media research: A quest for theoretically-grounded models

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    Contains fulltext : 62961-OA.pdf (publisher's version ) (Open Access)This article provides a panoramic sketch of the characteristics of community media and focuses on three forms: community television, community radio and community networks. The author contends, after a review of research conducted around these media, that much of this work has contributed little to the development of theoretical perspectives and theoretical model building suitable for guiding further empirical investigations. An illustration, taken from one theoretical perspective, is provided of the kind of model building that can be achieved. In conclusion, community media researchers are encouraged to take up the challenge associated with the general mandate for social scientists to contribute to theory, in this case through construction of theoretically-grounded models for understanding the place of community media in society
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