Giant Magnetic Moments of Nitrogen Stabilized Mn Clusters and Their Relevance to Ferromagnetism in Mn Doped GaN

Using first principles calculations based on density functional theory, we show that the stability and magnetic properties of small Mn clusters can be fundamentally altered by the presence of nitrogen. Not only are their binding energies substantially enhanced, but also the coupling between the magnetic moments at Mn sites remains ferromagnetic irrespective of their size or shape. In addition, these nitrogen stabilized Mn clusters carry giant magnetic moments ranging from 4 Bohr magnetons in MnN to 22 Bohr magnetons in Mn_5N. It is suggested that the giant magnetic moments of Mn_xN clusters may play a key role in the ferromagnetism of Mn doped GaN which exhibit a wide range (10K - 940K) of Curie temperatures

Parent-reported problems in children with Cerebral Visual Impairment:Improving the discriminative ability from ADHD and dyslexia using screening inventories

Daily problems of children with Cerebral Visual Impairment (CVI) are often misinterpreted as symptoms of behavioural disorders or learning disabilities instead of higher order visual function (HOVF) deficits. It is difficult to differentiate between various paediatric clinical groups based on daily manifestations. We used two CVI inventories (V-CVI-I, HVFQI) and an ADHD questionnaire (AVL) to compare parent-reported visual and behavioural problems of children with CVI, ADHD, dyslexia and neurotypical children (Age 6–15, Verbal Intelligence &gt; 70). Our results show a higher percentage of parent-reported visual problems in children with CVI compared to all other groups, which was not affected by their visual acuity levels. On most HOVF categories, a higher percentage of parent-reported visual problems was also found in children with ADHD or dyslexia compared to neurotypical children. Children with ADHD had significantly more parent-reported behavioural problems, but more behavioural problems were reported by the parents of children with CVI compared to neurotypical children as well. Our findings complicate using the existing inventories for initial screening and referral of children with potential CVI. We propose a shortened screening list to improve the potential differentiation between CVI and ADHD or dyslexia based on parent-reported visual problems in everyday life.</p

Targeting urine output and 30-day mortality in goal-directed therapy: A systematic review with meta-analysis and meta-regression.

Background: Oliguria is associated with a decreased kidney- and organ perfusion, leading to orga

Gut-microbiome composition in response to phenylketonuria depends on dietary phenylalanine in BTBR Pah^enu2 mice

Phenylketonuria (PKU) is a metabolic disorder caused by a hepatic enzyme deficiency causing high blood and brain levels of the amino acid Phenylalanine (Phe), leading to severe cognitive and psychological deficits that can be prevented, but not completely, by dietary treatment. The behavioral outcome of PKU could be affected by the gut-microbiome-brain axis, as diet is one of the major drivers of the gut microbiome composition. Gut-microbiome alterations have been reported in treated patients with PKU, although the question remains whether this is due to PKU, the dietary treatment, or their interaction. We, therefore, examined the effects of dietary Phe restriction on gut-microbiome composition and relationships with behavioral outcome in mice. Male and female BTBR Pah(enu2) mice received either a control diet (normal protein, “high” Phe), liberalized Phe-restricted (33% natural protein restriction), or severe Phe-restricted (75% natural protein restriction) diet with protein substitutes for 10 weeks (n = 14 per group). Their behavioral performance was examined in an open field test, novel and spatial object location tests, and a balance beam. Fecal samples were collected and sequenced for the bacterial 16S ribosomal RNA (rRNA) region. Results indicated that PKU on a high Phe diet reduced Shannon diversity significantly and altered the microbiome composition compared with wild-type animals. Phe-restriction prevented this loss in Shannon diversity but changed community composition even more than the high-Phe diet, depending on the severity of the restriction. Moreover, on a taxonomic level, we observed the highest number of differentially abundant genera in animals that received 75% Phe-restriction. Based on correlation analyses with differentially abundant taxa, the families Entereococacceae, Erysipelotrichaceae, Porphyromonadaceae, and the genus Alloprevotella showed interesting relationships with either plasma Phe levels and/or object memory. According to our results, these bacterial taxa could be good candidates to start examining the microbial metabolic potential and probiotic properties in the context of PKU. We conclude that PKU leads to an altered gut microbiome composition in mice, which is least severe on a liberalized Phe-restricted diet. This may suggest that the current Phe-restricted diet for PKU patients could be optimized by taking dietary effects on the microbiome into account

Continuum removal in H\alpha\ extragalactic measurements

We point out an important source of error in measurements of extragalactic H-alpha emission and suggest ways to reduce it. The H-alpha line, used for estimating star formation rates, is commonly measured by imaging in a narrow band and a wide band, both which include the line. The image analysis relies on the accurate removal of the underlying continuum. We discuss in detail the derivation of the emission line's equivalent width and flux for extragalactic extended sources, and the required photometric calibrations. We describe commonly used continuum-subtraction procedures, and discuss the uncertainties that they introduce. Specifically, we analyse errors introduced by colour effects. We show that the errors in the measured H-alpha equivalent width induced by colour effects can lead to underestimates as large as 40% and overestimates as large as 10%, depending on the underlying galaxy's stellar population and the continuum-subtraction procedure used. We also show that these errors may lead to biases in results of surveys, and to the underestimation of the cosmic star formation rate at low redshifts (the low z points in the Madau plot). We suggest a method to significantly reduce these errors using a single colour measurement.Comment: 8 pages, 3 figures, MNRAS in pres

The Evolutionary Status of Isolated Dwarf Irregular Galaxies II. Star Formation Histories and Gas Depletion

The results of UBV and H alpha imaging of a large sample of isolated dwarf irregular galaxies are interpreted in the context of composite stellar population models. The observed optical colors are best fit by composite stellar populations which have had approximately constant star formation rates for at least 10 Gyr. The galaxies span a range of central surface brightness, from 20.5 to 25.0 mag arcsec^{-2}; there is no correlation between surface brightness and star formation history. Although the current star formation rates are low, it is possible to reproduce the observed luminosities without a major starburst episode. The derived gas depletion timescales are long, typically ~20 Gyr. These results indicate that dwarf irregular galaxies will be able to continue with their slow, but constant, star formation activity for at least another Hubble time. The sample of isolated dIs is compared to a sample of star bursting dwarf galaxies taken from the literature. The star bursting dwarf galaxies have many similar properties; the main difference between these two types of gas-rich dwarf galaxies is that the current star formation is concentrated in the center of the star bursting systems while it is much more distributed in the quiescent dIs. This results in pronounced color gradients for the starbursting dwarf galaxies, while the majority of the quiescent dwarf irregular galaxies have minor or non-existent color gradients. Thus, the combination of low current star formation rates, blue colors, and the lack of significant color gradients indicates that star formation percolates slowly across the disk of normal dwarf galaxies in a quasi-continuous manner.Comment: 16 pages, uses emulateapj, to appear in The Astronomical Journal (April 2001

Gas distribution, kinematics and star formation in faint dwarf galaxies

We compare the gas distribution, kinematics and the current star formation in a sample of 10 very faint (-13.37 < M_B < -9.55) dwarf galaxies. For 5 of these galaxies we present fresh, high sensitivity, GMRT HI 21cm observations. For all our galaxies we construct maps of the HI column density at a constant linear resolution of ~300 pc; this forms an excellent data set to check for the presence of a threshold column density for star formation. We find that while current star formation (as traced by Halpha emission) is confined to regions with relatively large (N_HI > (0.4 -1.7) X 10^{21} atoms cm^{-2}) HI column density, the morphology of the Halpha emission is in general not correlated with that of the high HI column density gas. Thus, while high column density gas may be necessary for star formation, in this sample at least, it is not sufficient to ensure that star formation does in fact occur. We examine the line profiles of the HI emission, but do not find a simple relation between regions with complex line profiles and those with on-going star formation. Finally, we examine the very fine scale (~20-100 pc) distribution of the HI gas, and find that at these scales the emission exhibits a variety of shell like, clumpy and filamentary features. The Halpha emission is sometimes associated with high density HI clumps, sometimes the Halpha emission lies inside a high density shell, and sometimes there is no correspondence between the Halpha emission and the HI clumps. In summary, the interplay between star formation and gas density in these galaxy does not seem to show the simple large scale patterns observed in brighter galaxies (abridged).Comment: 15 pages, 6 tables, 13 figures. Accepted for publication in MNRA

Treatment limitation decisions in critically ill patients with a malignancy on the Intensive Care Unit

Background: Treatment limitation decisions (TLDs) on the ICU can be challenging, especially in patients with a malignancy. Up-to-date literature regarding TLDs in critically ill patients with a malignancy admitted to the ICU is scarce. The aim was to compare the incidence of written TLDs between patients with an active malignancy, patients with a malignancy in their medical history (complete remission, CR) and patients without a malignancy admitted unplanned to the ICU. Methods: We conducted a retrospective cohort study in a large university hospital in the Netherlands. We identified all unplanned admissions to the ICU in 2017 and categorized the patients in 3 groups: patients with an active malignancy (study population), with CR and without a malignancy. A TLD was defined as a written instruction not to perform life-saving treatments, such as CPR in case of cardiac arrest. A multivariate binary logistic regression analysis was used to identify whether having a malignancy was associated with TLDs. Results: Of the 1046 unplanned admissions, 125 patients (12%) had an active malignancy and 76 (7.3%) patients had CR. The incidence of written TLDs in these subgroups were 37 (29.6%) and 20 (26.3%). Age (OR 1.03; 95% CI 1.01 -1.04), SOFA score at ICU admission (OR 1.11; 95% CI 1.05 -1.18) and having an active malignancy (OR 1.75; 95% CI 1.04-2.96) compared to no malignancy were independently associated with written TLDs. SOFA scores on the day of the TLD were not significantly different in patients with and without a malignancy. Conclusions: This study shows that the presence of an underlying malignancy is independently associated with written TLDs during ICU stay. Patients with CR were not at risk of more written TLDs. Whether this higher incidence of TLDs in patients with a malignancy is justified, is at least questionable and should be evaluated in future research