Modern trends of scientific research and organizational methodological activities of Ural Scientific Research Institute of Dermatology, Venerology and Immunopathology

The paper presents main achivments of Ural Scientific Research Institute of Dermatology, Venerology an Immunopathology in scientific research and organizational methodological activities aimed at increasing of quality and accessibility of specialized medical care for patiens with chronical dermatoses, syphilis and other sexually transmitted diseases. Main trends of further development of Institute in current conditions of reorganization of National health care were defined.В статье представлены основные достижения Уральского научно-исследовательского института дерматовенерологии и иммунопатологии в научно-исследовательской и организационно-методической деятельности, направленной на повышение качество и доступности специализированной медицинской помощи больным хроническими дерматозами, сифилисом и другими инфекциями, передаваемыми половым путем. Определены основные направления дальнейшего развития института в современных условиях реорганизации отечественного здравоохранения

Experience in the treatment of psoriasis patients using Apremilast, a selective signalling pathway inhibitor

The article presents a brief description of Аpremilast — the target synthetic anti-inflammatory drug, which is representative of a new class of agents for the treatment of psoriasis and psoriatic arthritis. The efficiency and safety of the new drug in the treatment of patients with severe psoriasis are shown

Pathogenetic rationale for the application of cytostatics for the complex treatment of acantholytic pemphigus

Following a brief review on the etiology, pathogenesis, clinical and pathomorphological criteria of diagnostics and principles of treatment of Acantholytic Pemphigus, clinical cases of Pemphigus vulgaris and their complex treatment using subcutaneous injections of methotrexate are described. © Georg Thieme Verlag KG Stuttgart New York ISSN 0340-2541

Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc

Modern methods for acne scar correction. Review

The article presents recent data on the acne scars occurrence frequency, etiopathogenesis and classification. It was conducted the effectiveness analysis of existing methods of atrophic acne scars correction, including chemical peels, dermabrasion, needling, surgical techniques, fillers augmentation, laser and light therapy, objectively were assessed side effects and complications during treatment. It were reviewed indications, advantages and disadvantages of each method. The topicality, efficacy and safety of ablative fractional thermolysis were justified.В статье представлены современные данные о частоте встречаемости, этиопатогенезе и классификации рубцов постакне. Проведен анализ эффективности существующих методик коррекции атрофических рубцов постакне, в том числе с помощью химических пилингов, дермабразии, нидлинга, хирургических техник, аугментации филлерами, лазеро- и светотерапии, дана объективная оценка побочных действий и осложнений в процессе лечения. Рассмотрены показания, преимущества и недостатки каждого метода. Обоснована актуальность, эффективность и безопасность применения аблятивного фракционного термолиза

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity

A series of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines has been synthesized through oxidation reaction of the corresponding 3,6-disubstituted 1,2,4,5-tetrazines bearing amidine fragments. It is shown that the heterocyclic systems obtained can be modified easily at C(3) position in the reactions with aliphatic alcohols and amines. Also, the reactivity of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines towards CH-active compounds has been studied. The obtained triazolo[1,5-b]annulated 1,2,4,5-tetrazines proved to be active in micromolar concentrations in vitro against filamentous anthropophilic and zooanthropophilic dermatophyte fungi (Trichophyton, Microsporum and Epidermofiton), which cause skin and its appendages (hair, nails) diseases. © 2022 Korotina et al.; licensee Beilstein-Institut.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2020-777; Ural Branch, Russian Academy of Sciences, UB RASThis work was supported by the Ministry of Education and Science of the Russian Federation (Agreement No. 075-15-2020-777).Analytical studies were carried out using equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds”, located in Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences. This work was supported by the Ministry of Education and Science of the Russian Federation (Agreement No. 075-15-2020-777)

Epidemiology, diagnosis and treatment of self-inflicted dermatoses

The article presents current information of domestic and foreign literature about the epidemiology, clinical and laboratory diagnosis and treatment of self-inflicted dermatoses.Представлены современные данные отечественной и зарубежной литературы по вопросам эпидемиологии, клинико­лабораторной диагностики и лечения самовызванных дерматозов

Development of zinc pyrithione cream

Investigated effect of excipients on the organoleptic properties of cream zinc pyrithione. Cream containing zinc pyrithione and urea is optima] on the skin of patients with atopic dermatitis and psoriasis without exacerbation of the disease.Целью настоящей работы является разработка состава крема, определение концентрации вспомогательных и активных веществ, обеспечивающих увлажняющее, противовоспалительное и смягчающее действие на кожу больных атопическим дерматитом и псориазом в межрецидивный период

The Atmospheric Chemistry Suite (ACS) of Three Spectrometers for the ExoMars 2016 Trace Gas Orbiter

The Atmospheric Chemistry Suite (ACS) package is an element of the Russian contribution to the ESA-Roscosmos ExoMars 2016 Trace Gas Orbiter (TGO) mission. ACS consists of three separate infrared spectrometers, sharing common mechanical, electrical, and thermal interfaces. This ensemble of spectrometers has been designed and developed in response to the Trace Gas Orbiter mission objectives that specifically address the requirement of high sensitivity instruments to enable the unambiguous detection of trace gases of potential geophysical or biological interest. For this reason, ACS embarks a set of instruments achieving simultaneously very high accuracy (ppt level), very high resolving power (>10,000) and large spectral coverage (0.7 to 17 μm—the visible to thermal infrared range). The near-infrared (NIR) channel is a versatile spectrometer covering the 0.7–1.6 μm spectral range with a resolving power of ∼20,000. NIR employs the combination of an echelle grating with an AOTF (Acousto-Optical Tunable Filter) as diffraction order selector. This channel will be mainly operated in solar occultation and nadir, and can also perform limb observations. The scientific goals of NIR are the measurements of water vapor, aerosols, and dayside or night side airglows. The mid-infrared (MIR) channel is a cross-dispersion echelle instrument dedicated to solar occultation measurements in the 2.2–4.4 μm range. MIR achieves a resolving power of >50,000. It has been designed to accomplish the most sensitive measurements ever of the trace gases present in the Martian atmosphere. The thermal-infrared channel (TIRVIM) is a 2-inch double pendulum Fourier-transform spectrometer encompassing the spectral range of 1.7–17 μm with apodized resolution varying from 0.2 to 1.3 cm−1. TIRVIM is primarily dedicated to profiling temperature from the surface up to ∼60 km and to monitor aerosol abundance in nadir. TIRVIM also has a limb and solar occultation capability. The technical concept of the instrument, its accommodation on the spacecraft, the optical designs as well as some of the calibrations, and the expected performances for its three channels are described

Clinical efficacy and safety of topical treatment of atopic dermatitis

The article tells about results of clinical use of national non-hormonal topical treatment - Tsinokap cream. The active ingredient is zinc pyrithione 0.2% with anti-inflammatory, antibacterial and antifungal effect. A group of children with atopic dermatitis aged 1 to 16 years applied Tsinokap cream for 4 weeks. Clinical observations and analysis of dynamics of standardized SCORAD index during the treatment proved high efficiency of the therapy and its safety. Use of Tsinokap by patients with atopic dermatitis was associated with an increase in the quality of life in all age groups