Discovery of an unusual bright eclipsing binary with the longest known period: TYC 2505-672-1 / MASTER OT J095310.04+335352.8

We report on the MASTER Global Robotic Net discovery of an eclipsing binary, MASTER OT J095310.04+335352.8, previously known as unremarkable star TYC 2505-672-1, which displays extreme orbital parameters. The orbital period P=69.1 yr is more than 2.5 times longer than that of epsilon-Aurigae, which is the previous record holder. The light curve is characterized by an extremely deep total eclipse with a depth of more than 4.5 mag, which is symmetrically shaped and has a total duration of 3.5 yrs. The eclipse is essentially gray. The spectra acquired with the Russian 6 m BTA telescope both at minimum and maximum light mainly correspond to an M0-1III--type red giant, but the spectra taken at the bottom of eclipse show small traces of a sufficiently hot source. The observed properties of this system can be better explained as the red giant eclipsed by a large cloud (the disk) of small particles surrounding the invisible secondary companion.Comment: 8 figures, 9 pages, Astronomy and astrophysics in prin

The spectroscopic evolution of the symbiotic-like recurrent nova V407 Cygni during its 2010 outburst. II. The circumstellar environment and the aftermath

The nova outburst of V407 Cyg in 2010 Mar. 10 was the first observed for this star but its close resemblance to the well known symbiotic-like recurrent nova RS Oph suggests that it is also a member of this rare type of Galactic novae. The nova was the first detected at $\gamma$-ray energies and is the first known nova explosion for this system. The extensive multiwavelength coverage of this outburst makes it an ideal comparison with the few other outbursts known for similar systems. We extend our previous analysis of the Mira and the expanding shock from the explosion to detail the time development of the photoionized Mira wind, circumstellar medium, and shocked circumstellar environment to derive their physical parameters and how they relate to large scale structure of the environment, extending the previous coverage to more than 500 days after outburst. Absorption lines of Fe-peak ions formed in the Mira wind were visible as P Cyg profiles at low velocity before Day 69, around the time of the X-ray peak and we identified many absorption transitions without accompanying emission for metal lines. The H Balmer lines showed strong P Cyg absorption troughs that weakened during the 2010 observing period, through Day 128. We distinguish the components from the shock, the photoionized environment, and the chromosphere and inner Mira wind using spectra taken more than one year after outburst. The multiple shells and radiative excitation phenomenology are similar to those recently cited for GRBs and SNIa (severely truncated)Comment: accepted for publication in A&A (9/12/11

АССОЦИАЦИИ ПОЛИМОРФИЗМА ГЕНА ADRA2B С ФАКТОРАМИ РИСКА СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ В ПОПУЛЯЦИИ КОРЕННЫХ ЖИТЕЛЕЙ ГОРНОЙ ШОРИИ

Study objectives: examine the frequency of genotypes and alleles of I/D polymorphism of gene ADRA2B of native people living in Mountain Shoria (the Shors), as well as their association with risk factors for cardiovascular diseases.Material and methods. Overall 221 native people of Shoria were examined. The average age is51.07 ± 1.46 among males, 52.93 ± 0.96 among females (p = 0.286). Anthropometric characteristics, lipid levels of blood and I/D polymorphism of ADRA2B were studied.Results. DD genotype of the gene ADRA2B in the native population of the Shor people is associated with adiposis and high index of "waist/hip", hypertriglyceridemia. The average values of Quetelet index is higher in carriers of this genotype compared with carriers of genotype ID. Average waist indications in homozygous insertions were lower than those in homozygous deletions and heterozygotes. Patients with genotype DD have higher average levels of triglycerides, atherogenic index, cholesterol, very low density lipoproteins.Conclusion. DD allele ADRA2B genotype is responsible for adiposis and high levels of TG among native population of Shoria.Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАН, Кемерово; Новокузнецкий государственный институт усовершенствования врачей, НовокузнецкЦель исследования – изучить частоты генотипов и аллелей I/D полиморфизма гена ADRA2B в популяции коренных жителей Горной Шории (шорцев), а также их ассоциацию с факторами риска сердечно-сосудистых заболеваний.Материал и методы. Проведено клинико-эпидемиологическое исследование коренного населения труднодоступных районов Горной Шории. Сплошным методом обследован 221 человек, выборка состояла из взрослого населения (лица в возрасте 18 лет и старше). Средний возраст обследуемых составил (51,07 ± 1,46) лет у мужчин, (52,93 ± 0,96) лет у женщин (p = 0,286). Изучены антропометрические данные, показатели липидного спектра крови, I/D полиморфизм гена ADRA2B.Результаты. Генотип DD гена ADRA2B в популяции шорцев ассоциируется с ожирением и повышенным индексом «талия/бедро», гипертриглицеридемией. Средние значения индекса Кетле выше у носителей данного генотипа по сравнению с носителями генотипа ID. У гомозигот по инсерции средние показатели окружности талии оказались меньше, чем у гомозигот по делеции и у гетерозигот. Средние уровни триглицеридов, индекса атерогенности, холестерина липопротеинов очень низкой плотности были выше у лиц с генотипом DD.Заключение. В популяции шорцев маркером генетической предрасположенности к ожирению, нарушению распределения жировой ткани и гипертриглицеридемии является аллель D гена а2В-адренорецептора

Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis

Gallstone disease (GSD) and arterial hypertension (AH) have many common risk factors – age, overweight, dyslipidemia, low physical activity, diabetes mellitus, in addition, the presence of AH is considered by many authors as a risk factor for GSD. Numerous trials are devoted to the study of the contribution of gene polymorphisms in the development of AH, but researches about common candidate genes for AH and GSD are rare. In several studies, including a meta-analysis, the association of GSD and APOE4 allele genotype is depicted. Our clinical study in women with GSD in combination with AH shows the greatest frequency of allele APOE4 (21.2) compared with women with GSD without AH (8.0) or with women with isolated AH (10.6, p < 0.05). Also in this study, we found no significant differences in the frequency of genotypes A/A, A/G and G/G polymorphism A145G ADRB1 gene in women with AH in combination with GSD and women with isolated AH. Earlier in epidemiological study we did not found any association of GSD with I/D polymorphism of angiotensin converting enzyme gene. Thus, further research is needed to find a common candidate genes involved in the regulation of blood pressure and in the development of GSD in each population that will help identify patients at highest risk of complications of GSD and AH

VIRTUAL MULTISLICE-CT-BRONCHOSCOPY AS A DIAGNOSTIC TOOL IN PATIENTS WITH BRONCHIAL TUMORS

Purpose: to study the role of virtual multislice-CT-bronchoscopy in the detection of bronchial tumors and assessment of bronchial tumor extension. Material and methods. Findings of the virtual multislice-CTbronchoscopy were analyzed in 61 patients with primary and secondary bronchial tumors. Virtual multislice-CTbronchoscopy was performed using the AquilionONE (320-slice) CT scanner. Results. Virtual bronchoscopy revealed 3 types of bronchial involvement: peribronchial, intrabronchial and mixed tumor infiltrations. The virtual fly through bronchoscopy was used to assess the macrostructure and tumor margins in patients with intrabronchial tumor growth. Broad-based polypoid masses causing the obstructing narrowing of the bronchus were visualized inside the bronchial lumen. The narrowing of the bronchial lumen and no visualization of the cartilaginous structures (the bronchus turned into the deformed tubular structure) were the signs of infiltration of the main bronchi and the trachea. In patients with lung and hilar lymph node metastases, infiltration of segmental and lobar bronchi led to the impaired ventilation of the affected segments or lobes of the lungs, thus resulting in the development of atelectasis. In patients with benign tumors, the lesion was characterized by the regular shape, smooth surface and homogeneous internal structure, as well as the absence of infiltration of the bronchial wall. Conclusion. Virtual multislice-CT-bronchoscopy with multiplanar and three dimensional reconstruction is a reliable noninvasive method for accurate diagnosis of bronchial involvement and the differential diagnosis between extrinsic pressure on the bronchial tree and bronchial tumor

Polymorphism taqib (rs708272) gene protein cholesterol ester transfer (CETP) in women with autoimmune thyroiditis with the result of hypothyroidism

Objective: To study the polymorphism TaqIB (rs708272) gene protein cholesterolоl ester transfer (CETP) in women with autoimmune thyroiditis. Materials and Methods: We examined 98 women with autoimmune thyroiditis, mean age 55.2 ± 7.8 years, disease duration 8.0 ± 6.4 years, menopause duration 6.4 ± 3.5 years. The average dose of L-thyroxine 84.3 ± 28.5. Control group consisted of 135 women of similar age without thyroid pathology. Polymorphism of TaqIB (rs708272) CETP gene formed by PCR RFLP on published by technique. Results: As a result, it was found that in the group of women with AIT В1В1 and В2В2 genotypes determined in 37.8 % and 21.4 %. Win В1В2 heterozygotes in patients with hypothyroidism compared with the control group was significantly lower: 40.8 % and 54.8 %, p = 0.035. Average levels of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides were not significantly different in carriers of different genotypes of TaqIB polymorphism (rs708272) CETP gene in the two groups

МАГНИТНО-РЕЗОНАНСНАЯ И КОМПЬЮТЕРНАЯ ТОМОГРАФИЯ В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ЭКТОПИИ ТКАНИ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ И ЗАБРЮШИННОЙ ОПУХОЛИ

A rare clinical observation of retroperitoneal ectopy of pancreatic tissue with diligence to the kidney and jejunum is presented. For the first time, semiotics of ectopia is described according to the data of magnetic resonance imaging, which is compared with computer tomography data and allows to perform differential diagnostics with a retroperitoneal tumor with a high degree of reliability, to determine whether the revealed structures belong to the tissues of the pancreas.Представлено редкое клиническое наблюдение забрюшинной эктопии ткани поджелудочной железы с прилежанием к почке и тощей кишки. Впервые описана семиотика эктопии по данным магнитно-резонансной томографии, которая сопоставлена с  результатами компьютерной томографии и  позволяет с  высокой степенью достоверности провести дифференциальную диагностику с  забрюшинной опухолью, определить принадлежность выявленных структур к тканям поджелудочной железы

МАГНИТНО-РЕЗОНАНСНАЯ И КОМПЬЮТЕРНАЯ ТОМОГРАФИЯ В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ЭКТОПИИ ТКАНИ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ И ЗАБРЮШИННОЙ ОПУХОЛИ

A rare clinical observation of retroperitoneal ectopy of pancreatic tissue with diligence to the kidney and jejunum is presented. For the first time, semiotics of ectopia is described according to the data of magnetic resonance imaging, which is compared with computer tomography data and allows to perform differential diagnostics with a retroperitoneal tumor with a high degree of reliability, to determine whether the revealed structures belong to the tissues of the pancreas.Представлено редкое клиническое наблюдение забрюшинной эктопии ткани поджелудочной железы с прилежанием к почке и тощей кишки. Впервые описана семиотика эктопии по данным магнитно-резонансной томографии, которая сопоставлена с  результатами компьютерной томографии и  позволяет с  высокой степенью достоверности провести дифференциальную диагностику с  забрюшинной опухолью, определить принадлежность выявленных структур к тканям поджелудочной железы