Neck atonia with a focal stimulation-induced seizure arising from the SMA: pathophysiological considerations.

A 28-year-old patient with pharmacoresistant non-lesional right frontal epilepsy underwent extra-operative intracranial EEG recordings and electrical cortical stimulation (ECS) to map eloquent cortex. Right supplementary motor area (SMA) ECS induced a brief seizure with habitual symptoms involving neck tingling followed by asymmetric tonic posturing. An additional feature was neck atonia. During atonia and sensory aura, discharges were seen in the mesial frontal electrodes and precentral gyrus. Besides motor signs, atonia, although rare and not described in the neck muscles, and sensations have been reported with SMA stimulation. The mechanisms underlying neck atonia in seizures arising from the SMA can be explained by supplementary negative motor area (SNMA) - though this was not mapped in electrodes overlying the ictal onset zone in our patient - or primary sensorimotor cortex activation through rapid propagation. Given the broad spectrum of signs elicited by SMA stimulation and rapid spread of seizures arising from the SMA, caution should be taken to not diagnose these as non-epileptic, as had previously occurred in this patient

RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes

The RegPrecise database (http://regprecise.lbl.gov) was developed for capturing, visualization and analysis of predicted transcription factor regulons in prokaryotes that were reconstructed and manually curated by utilizing the comparative genomic approach. A significant number of high-quality inferences of transcriptional regulatory interactions have been already accumulated for diverse taxonomic groups of bacteria. The reconstructed regulons include transcription factors, their cognate DNA motifs and regulated genes/operons linked to the candidate transcription factor binding sites. The RegPrecise allows for browsing the regulon collections for: (i) conservation of DNA binding sites and regulated genes for a particular regulon across diverse taxonomic lineages; (ii) sets of regulons for a family of transcription factors; (iii) repertoire of regulons in a particular taxonomic group of species; (iv) regulons associated with a metabolic pathway or a biological process in various genomes. The initial release of the database includes ∼11 500 candidate binding sites for ∼400 orthologous groups of transcription factors from over 350 prokaryotic genomes. Majority of these data are represented by genome-wide regulon reconstructions in Shewanella and Streptococcus genera and a large-scale prediction of regulons for the LacI family of transcription factors. Another section in the database represents the results of accurate regulon propagation to the closely related genomes

PASTIS: Bayesian extrasolar planet validation II. Constraining exoplanet blend scenarios using spectroscopic diagnoses

The statistical validation of transiting exoplanets proved to be an efficient technique to secure the nature of small exoplanet signals which cannot be established by purely spectroscopic means. However, the spectroscopic diagnoses are providing us with useful constraints on the presence of blended stellar contaminants. In this paper, we present how a contaminating star affects the measurements of the various spectroscopic diagnoses as function of the parameters of the target and contaminating stars using the model implemented into the PASTIS planet-validation software. We find particular cases for which a blend might produce a large radial velocity signal but no bisector variation. It might also produce a bisector variation anti-correlated with the radial velocity one, as in the case of stellar spots. In those cases, the full width half maximum variation provides complementary constraints. These results can be used to constrain blend scenarios for transiting planet candidates or radial velocity planets. We review all the spectroscopic diagnoses reported in the literature so far, especially the ones to monitor the line asymmetry. We estimate their uncertainty and compare their sensitivity to blends. Based on that, we recommend the use of BiGauss which is the most sensitive diagnosis to monitor line-profile asymmetry. In this paper, we also investigate the sensitivity of the radial velocities to constrain blend scenarios and develop a formalism to estimate the level of dilution of a blended signal. Finally, we apply our blend model to re-analyse the spectroscopic diagnoses of HD16702, an unresolved face-on binary which exhibits bisector variations.Comment: Accepted for publication in MNRA

Novel Single Photon Detectors for UV Imaging

There are several applications which require high position resolution UV imaging. For these applications we have developed and successfully tested a new version of a 2D UV single photon imaging detector based on a microgap RPC. The main features of such a detectors is the high position resolution - 30 micron in digital form and the high quantum efficiency (1-8% in the spectral interval of 220-140 nm). Additionally, they are spark- protected and can operate without any feedback problems at high gains, close to a streamer mode. In attempts to extend the sensitivity of RPCs to longer wavelengths we have successfully tested the operation of the first sealed parallel-plate gaseous detectors with CsTe photocathodes. Finally, the comparison with other types of photosensitive detectors is given and possible fields of applications are identified.Comment: Presented at the 5th International Workshop on RICH detectors Playa del Carmen, Mexico, November 200

The Energy Level Shifts, Wave Functions and the Probability Current Distributions for the Bound Scalar and Spinor Particles Moving in a Uniform Magnetic Field

We discuss the equations for the bound one-active electron states based on the analytic solutions of the Schrodinger and Pauli equations for a uniform magnetic field and a single attractive $\delta({\bf r})$-potential. It is vary important that ground electron states in the magnetic field differ essentially from the analogous state of spin-0 particles, whose binding energy was intensively studied more than forty years ago. We show that binding energy equations for spin-1/2 particles can be obtained without using the language of boundary conditions in the $\delta$-potential model developed in pioneering works. We use the obtained equations to calculate the energy level displacements analytically and demonstrate nonlinear dependencies on field intensity. We show that the magnetic field indeed plays a stabilizing role in considered systems in a case of the weak intensity, but the opposite occurs in the case of strong intensity. These properties may be important for real quantum mechanical fermionic systems in two and three dimensions. We also analyze the exact solution of the Pauli equation for an electron moving in the potential field determined by the three-dimensional $\delta$-well in the presence of a strong magnetic field. We obtain asymptotic expressions for this solution for different values of the problem parameters. In addition, we consider electron probability currents and their dependence on the magnetic field. We show that including the spin in the framework of the nonrelativistic approach allows correctly taking the effect of the magnetic field on the electric current into account. The obtained dependencies of the current distribution, which is an experimentally observable quantity, can be manifested directly in scattering processes, for example.Comment: 31 pages, 10 figure

Estimating the Dark Halo Mass from the Relative Thickness of Stellar Disks

We analyze the relationship between the mass of a spherical component and the minimum possible thickness of stable stellar disks. This relationship for real galaxies allows the lower limit on the dark halo mass to be estimated (the thinner the stable stellar disk is, the more massive the dark halo must be). In our analysis, we use both theoretical relations and numerical N-body simulations of the dynamical evolution of thin disks in the presence of spherical components with different density profiles and different masses. We conclude that the theoretical relationship between the thickness of disk galaxies and the mass of their spherical components is a lower envelope for the model data points. We recommend using this theoretical relationship to estimate the lower limit for the dark halo mass in galaxies. The estimate obtained turns out to be weak. Even for the thinnest galaxies, the dark halo mass within four exponential disk scale lengths must be more than one stellar disk mass.Comment: 20 pages including 6 figures. To be published in Astronomy Letters (v. 32, No. 10, pp. 649-660, 2006

Out-of-Equilibrium Admittance of Single Electron Box Under Strong Coulomb Blockade

We study admittance and energy dissipation in an out-of-equlibrium single electron box. The system consists of a small metallic island coupled to a massive reservoir via single tunneling junction. The potential of electrons in the island is controlled by an additional gate electrode. The energy dissipation is caused by an AC gate voltage. The case of a strong Coulomb blockade is considered. We focus on the regime when electron coherence can be neglected but quantum fluctuations of charge are strong due to Coulomb interaction. We obtain the admittance under the specified conditions. It turns out that the energy dissipation rate can be expressed via charge relaxation resistance and renormalized gate capacitance even out of equilibrium. We suggest the admittance as a tool for a measurement of the bosonic distribution corresponding collective excitations in the system