Individual Budgets : Lessons from Early Users' Experiences

Within the context of modernization, there has been a trend towards 'cash-for-care' schemes designed to bring choice and control closer to the service user. In England, Individual Budgets (IBs) are being piloted, with the aim of promoting personalized support for disabled people and other users of social care services. This paper reports on the experiences and outcomes of early IB users two to three months after first being offered an IB. The users included adults with physical/sensory impairments, learning difficulties, mental health problems and older people. Semi-structured interviews were carried out with nine service users and five proxies. The findings suggest that IBs have the potential to be innovative and life-enhancing. However, achieving this potential in practice depends on a range of other factors, including changes in the routine practices and organizational culture of adult social care services and ensuring users have access to appropriate documentation and support. Any conclusions drawn from the experiences of these early IB users must be treated with caution. The findings nevertheless indicate some of the issues that will need to be addressed as IBs are implemented more widely to replace conventional forms of adult social care provision

Massive Stellar Content of the Galactic Supershell GSH 305+01-24

The distribution of OB stars along with that of H$\alpha$, $^{12}$CO, dust infrared emission, and neutral hydrogen is carried out in order to provide a more complete picture of interactions of the young massive stars and the observed supershell GSH 305+01-24. The studied field is located between $299^\circ \le l \le 311^\circ$ and $-5^\circ \le b \le 7^\circ$. The investigation is based on nearly 700 O-B9 stars with $uvby\beta$ photometry currently available. The derived stellar physical parameters were used to establish a homogeneous scale for the distances and extinction of light for major apparent groups and layers of foreground and background stars in Centaurus and study the interaction with the surrounding interstellar medium. The distance to the entire Centaurus star-forming complex is revised and a maximum of the OB-star distance distribution is found at 1.8$\pm$0.4 (r.m.s) kpc. The massive star component of GSH 305+01-24 is identified at about 85-90 % completeness up to 11.5-12 mag. The projected coincidence of the OB stars with the shell and the similarities between the shell's morphology and the OB-star distribution indicate a strong interaction of the stellar winds with the superbubble material. We demonstrate that these stars contribute a sufficient wind injection energy in order to explain the observed size and expansion velocity of the supershell. The derived stellar ages suggest an age gradient over the Coalsack Loop. A continuous star-formation might be taking place within the shell with the youngest stars located at its periphery and the open cluster NGC 4755 being the oldest. A layer of very young stars at 1 kpc is detected and its connection to both GSH 305+01-24 and the foreground GSH 304-00-12 H I shells is investigated.Comment: Accepted for publication in A&A. Paper consists of 11 pages, 3 tables and 9 figures. Table 1 and Table 3 will only be available from CD

Investigations in space-related molecular biology

Improved instrumentation and preparation techniques for high resolution, high voltage cryo-electron microscopic and diffraction studies on terrestrial and extraterrestrial specimens are reported. Computer correlated ultrastructural and biochemical work on hydrated and dried cell membranes and related biological systems provided information on membrane organization, ice crystal formation and ordered water, RNA virus linked to cancer, lunar rock samples, and organometallic superconducting compounds. Apollo 11, 12, 14, and 15 specimens were analyze

Flight test of navigation and guidance sensor errors measured on STOL approaches

Navigation and guidance sensor error characteristics were measured during STOL approach-flight investigations. Data from some of the state sensors of a digital avionics system were compared to corresponding outputs from an inertial navigation system. These sensors include the vertical gyro, compass, and accelerometers. Barometric altimeter data were compared to altitude measured by a tracking radar. Data were recorded with the Augmentor Wing Jet STOL Research Aircraft parked and in flight

User's manual: Subsonic/supersonic advanced panel pilot code

Sufficient instructions for running the subsonic/supersonic advanced panel pilot code were developed. This software was developed as a vehicle for numerical experimentation and it should not be construed to represent a finished production program. The pilot code is based on a higher order panel method using linearly varying source and quadratically varying doublet distributions for computing both linearized supersonic and subsonic flow over arbitrary wings and bodies. This user's manual contains complete input and output descriptions. A brief description of the method is given as well as practical instructions for proper configurations modeling. Computed results are also included to demonstrate some of the capabilities of the pilot code. The computer program is written in FORTRAN IV for the SCOPE 3.4.4 operations system of the Ames CDC 7600 computer. The program uses overlay structure and thirteen disk files, and it requires approximately 132000 (Octal) central memory words

Evolutionary history of the ADRB2 gene in humans

No abstract available

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement.

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP. TP deficiency leads to plasma and tissue accumulations of thymidine and deoxyuridine which generate imbalances within the mitochondrial nucleotide pools, ultimately leading to mitochondrial dysfunction.1 MNGIE is characterized clinically by leukoencephalopathy, external ophthalmoplegia, peripheral polyneuropathy, cachexia, and enteric neuromyopathy manifesting as gastrointestinal dysmotility. The condition is relentlessly progressive, with patients usually dying from a combination of nutritional and neuromuscular failure at an average age of 37 years.2 Allogeneic hematopoietic stem cell transplantation (AHSCT) offers a permanent cure. Clinical and biochemical improvements following AHSCT have been reported but it carries a high mortality risk and is limited by matched donor availability.3 A consensus proposal for standardizing AHSCT recommends treatment of patients without irreversible end-stage disease and with an optimally matched donor; a majority of patients are ineligible and thus there is a critical requirement for an alternative treatment

Evolution of the Stellar Mass--Metallicity Relation - I: Galaxies in the z~0.4 Cluster Cl0024

We present the stellar mass-stellar metallicity relationship (MZR) in the Cl0024+1654 galaxy cluster at z~0.4 using full spectrum stellar population synthesis modeling of individual quiescent galaxies. The lower limit of our stellar mass range is $M_*=10^{9.7}M_\odot$, the lowest galaxy mass at which individual stellar metallicity has been measured beyond the local universe. We report a detection of an evolution of the stellar MZR with observed redshift at $0.037\pm0.007$ dex per Gyr, consistent with the predictions from hydrodynamical simulations. Additionally, we find that the evolution of the stellar MZR with observed redshift can be explained by an evolution of the stellar MZR with their formation time, i.e., when the single stellar population (SSP)-equivalent ages of galaxies are taken into account. This behavior is consistent with stars forming out of gas that also has an MZR with a normalization that decreases with redshift. Lastly, we find that over the observed mass range, the MZR can be described by a linear function with a shallow slope, ($[Fe/H] \propto (0.16 \pm 0.03) \log M_*$). The slope suggests that galaxy feedback, in terms of mass-loading factor, might be mass-independent over the observed mass and redshift range.Comment: 22 pages, 10 figures. Accepted for publication in Ap