Plasmas generated by ultra-violet light rather than electron impact

We analyze, in both plane and cylindrical geometries, a collisionless plasma consisting of an inner region where generation occurs by UV illumination, and an un-illuminated outer region with no generation. Ions generated in the inner region flow outwards through the outer region and into a wall. We solve for this system's steady state, first in the quasi-neutral regime (where the Debye length ${\lambda}_D$ vanishes and analytic solutions exist) and then in the general case, which we solve numerically. In the general case a double layer forms where the illuminated and un-illuminated regions meet, and an approximately quasi-neutral plasma connects the double layer to the wall sheath; in plane geometry the ions coast through the quasi-neutral section at slightly more than the Bohm speed $c_s$. The system, although simple, therefore has two novel features: a double layer that does not require counter-streaming ions and electrons, and a quasi-neutral plasma where ions travel in straight lines with at least the Bohm speed. We close with a pr\'{e}cis of our asymptotic solutions of this system, and suggest how our theoretical conclusions might be extended and tested in the laboratory.Comment: 10 pages, 3 figures, accepted by Physics of Plasma

Photographic Assessment of Change in Trichotillomania: Psychometric Properties and Variables Influencing Interpretation

Although photographic assessment has been found to be reliable in assessing hair loss in Trichotillomania, the validity of this method is unclear, particularly for gauging progress in treatment. The current study evaluated the psychometric properties of photographic assessment of change in Trichotillomania. Photographs showing hair loss of adults with Trichotillomania were taken before and after participating in a clinical trial for the condition. Undergraduate college students (N = 211) rated treatment response according to the photos, and additional archival data on hair pulling severity and psychosocial health were retrieved from the clinical trial. Photographic assessment of change was found to possess fair reliability (ICC = 0.53), acceptable criterion validity (r = 0.51), good concurrent validity (r = 0.30–0.36), and excellent incremental validity (ΔR2 = 8.67, p \u3c 0.01). In addition, photographic measures were significantly correlated with change in quality of life (r = 0.42), and thus could be considered an index of the social validity of Trichotillomania treatment. Gender of the photo rater and pulling topography affected the criterion validity of photographic assessment (partial η2 = 0.05–0.11). Recommendations for improving photographic assessment and future directions for hair pulling research are discussed

Shortcuts to Spherically Symmetric Solutions: A Cautionary Note

Spherically symmetric solutions of generic gravitational models are optimally, and legitimately, obtained by expressing the action in terms of the two surviving metric components. This shortcut is not to be overdone, however: a one-function ansatz invalidates it, as illustrated by the incorrect solutions of [1].Comment: 2 pages. Amplified derivation, accepted for publication in Class Quant Gra

Facilitators and Barriers to Safe Medication Administration to Hospital Inpatients: A Mixed Methods Study of Nurses' Medication Administration Processes and Systems (the MAPS Study).

Research has documented the problem of medication administration errors and their causes. However, little is known about how nurses administer medications safely or how existing systems facilitate or hinder medication administration; this represents a missed opportunity for implementation of practical, effective, and low-cost strategies to increase safety

Animal Research: A Review of Developments, 1950–2000

The third phase of the animal research debate started around 1950. After World War II the government became a major sponsor of scientific research, including biomedical research. The budget of the National Institutes of Health (NIH) grew dramatically and has continued to grow, with a few minor retrenchment periods, up to the present time (see Figure 1). This growth led to an enormous expansion in publicly funded research. In the private sector, the discovery of penicillin and streptomycin led to a tremendous expansion in pharmaceutical research and in the size of the prescription drug industry. These expansions in government funding for biomedical research and in private-sector investment in drug discovery created an increase in demand for laboratory animals

Urban Lymphatic Filariasis in the Metropolis of\ud Dar es Salaam, Tanzania

The last decades have seen a considerable increase in urbanization in Sub-Saharan Africa, and it is estimated that over 50% of the population will live in urban areas by 2040. Rapid growth of cities combined with limited economic resources often result in informal settlements and slums with favorable conditions for proliferation of vectors of lymphatic filariasis (LF). In Dar es Salaam, which has grown more than 30 times in population during the past 55 years (4.4 million inhabitants in 2012), previous surveys have indicated high prevalences of LF. This study investigated epidemiological aspects of LF in Dar es Salaam, as a background for planning and implementation of control. Six sites with varying distance from the city center (3–30 km) and covering different population densities, socioeconomic characteristics, and water, sewerage and sanitary facilities were selected for the study. Pupils from one public primary school at each site were screened for circulating filarial antigen (CFA; marker of adult worm infection) and antibodies to Bm14 (marker of exposure to transmission). Community members were examined for CFA, microfilariae and chronic manifestations. Structured questionnaires were administered to pupils and heads of community households, and vector surveys were carried out in selected households. The study indicated that a tremendous decrease in the burden of LF infection had occurred, despite haphazard urbanisation. Contributing factors may be urban malaria control targeting Anopheles vectors, short survival time of the numerous Culex quinquefasciatus vectors in the urban environment, widespread use of bed nets and other mosquito proofing measures, and mass drug administration (MDA) in 2006 and 2007. Although the level of ongoing transmission was low, the burden of chronic LF disease was still high. The development has so far been promising, but continued efforts are necessary to ensure elimination of LF as a public health problem. These will include improving the awareness of people about the role of mosquitoes in transmission of LF, more thorough implementation of environmental sanitation to reduce Cx. Quinquefasciatus breeding, continued MDA to high-risk areas, and set-up of programmes for management of chronic LF disease

Switchable Genetic Oscillator Operating in Quasi-Stable Mode

Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, these attractors may not fully explain the observed behavior in transient and stochastic environments such as the cell. We show here that even repressilators possess quasi-stable, travelling-wave periodic solutions that are reachable, long-lived and robust to parameter changes. These solutions underlie the sustained oscillations observed in even rings in the stochastic regime, even if these circuits are expected to behave as switches. The existence of such solutions can also be exploited for control purposes: operation of the system around the quasi-stable orbit allows us to turn on and off the oscillations reliably and on demand. We illustrate these ideas with a simple protocol based on optical interference that can induce oscillations robustly both in the stochastic and deterministic regimes.Comment: 24 pages, 5 main figure

Subtleties on energy calculations in the image method

In this pedagogical work we point out a subtle mistake that can be done by undergraduate or graduate students in the computation of the electrostatic energy of a system containing charges and perfect conductors if they naively use the image method. Specifically, we show that the naive expressions for the electrostatic energy for these systems obtained directly from the image method are wrong by a factor 1/2. We start our discussion with well known examples, namely, point charge-perfectly conducting wall and point charge-perfectly conducting sphere and then proceed to the demonstration of general results, valid for conductors of arbitrary shapes.Comment: 9 pages, 2 figures; Major change in this version: subsection added to Sect.4 (theorem generalization). Minor changes: title replaced; corrections to the English; some explanatory comments adde

Intrinsic thermal vibrations of suspended doubly clamped single-wall carbon nanotubes

We report the observation of thermally driven mechanical vibrations of suspended doubly clamped carbon nanotubes, grown by chemical vapor deposition (CVD). Several experimental procedures are used to suspend carbon nanotubes. The vibration is observed as a blurring in images taken with a scanning electron microscope. The measured vibration amplitudes are compared with a model based on linear continuum mechanics.Comment: pdf including figures, see: http://www.unibas.ch/phys-meso/Research/Papers/2003/NT-Thermal-Vibrations.pd