Signal quality measures for unsupervised blood pressure measurement

Accurate systolic and diastolic pressure estimation, using automated blood pressure measurement, is difficult to achieve when the transduced signals are contaminated with noise or interference, such as movement artifact. This study presents an algorithm for automated signal quality assessment in blood pressure measurement by determining the feasibility of accurately detecting systolic and diastolic pressures when corrupted with various levels of movement artifact. The performance of the proposed algorithm is compared to a manually annotated reference scoring (RS). Based on visual representations and audible playback of Korotkoff sounds, the creation of the RS involved two experts identifying sections of the recorded sounds and annotating sections of noise contamination. The experts determined the systolic and diastolic pressure in 100 recorded Korotkoff sound recordings, using a simultaneous electrocardiograph as a reference signal. The recorded Korotkoff sounds were acquired from 25 healthy subjects (16 men and 9 women) with a total of four measurements per subject. Two of these measurements contained purposely induced noise artifact caused by subject movement. Morphological changes in the cuff pressure signal and the width of the Korotkoff pulse were extracted features which were believed to be correlated with the noise presence in the recorded Korotkoff sounds. Verification of reliable Korotkoff pulses was also performed using extracted features from the oscillometric waveform as recorded from the inflatable cuff. The time between an identified noise section and a verified Korotkoff pulse was the key feature used to determine the validity of possible systolic and diastolic pressures in noise contaminated Korotkoff sounds. The performance of the algorithm was assessed based on the ability to: verify if a signal was contaminated with any noise; the accuracy, sensitivity and specificity of this noise classification, and the systolic and diastolic pressure differences between the result obtained from the algorithm and the RS. 90% of the actual noise contaminated signals were correctly identified, and a sample-wise accuracy, sensitivity and specificity of 97.0%, 80.61% and 98.16%, respectively, were obtained from 100 pooled signals. The mean systolic and diastolic differences were 0.37 ± 3.31 and 3.10 ± 5.46 mmHg, respectively, when the artifact detection algorithm was utilized, with the algorithm correctly determined if the signal was clean enough to attempt an estimation of systolic or diastolic pressures in 93% of blood pressure measurements

The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP

The zinc finger antiviral protein (ZAP) is known to restrict viral replication by binding to the CpG rich regions of viral RNA, and subsequently inducing viral RNA degradation. This enzyme has recently been shown to be capable of restricting SARS-CoV-2. These data have led to the hypothesis that the low abundance of CpG in the SARS-CoV-2 genome is due to an evolutionary pressure exerted by the host ZAP. To investigate this hypothesis, we performed a detailed analysis of many coronavirus sequences and ZAP RNA binding preference data. Our analyses showed neither evidence for an evolutionary pressure acting specifically on CpG dinucleotides, nor a link between the activity of ZAP and the low CpG abundance of the SARS-CoV-2 genome

Earth Radiation Budget Experiment (ERBE) scanner instrument anomaly investigation

The results of an ad-hoc committee investigation of in-Earth orbit operational anomalies noted on two identical Earth Radiation Budget Experiment (ERBE) Scanner instruments on two different spacecraft busses is presented. The anomalies are attributed to the bearings and the lubrication scheme for the bearings. A detailed discussion of the pertinent instrument operations, the approach of the investigation team and the current status of the instruments now in Earth orbit is included. The team considered operational changes for these instruments, rework possibilities for the one instrument which is waiting to be launched, and preferable lubrication considerations for specific space operational requirements similar to those for the ERBE scanner bearings

On the influence of the Sun on the rapid variability of compact extragalactic sources

Starting from December 2004, a program for the monitoring of intraday variable sources at a frequency of 5 GHz was performed at the Urumqi Observatory. The analysis of the variability characteristics of the flat-spectrum radio source AO 0235+164 revealed the existence of an annual cycle in the variability amplitude. This appears to correlate with the solar elongation of the source. A thorough analysis of the results of the MASIV IDV survey --- which provides the variability characteristics of a large sample of compact radio sources --- confirms that there is a small but detectable component of the observed fractional modulation which increases with decreasing solar elongation. We discuss the hypothesis that the phenomenon is related to interplanetary scintillation.Comment: 10 pages, 12 figures and 2 tables. Accepted for publication in Astronomy and Astrophysic

A seasonal cycle and an abrupt change in the variability characteristics of the intraday variable source S4 0954+65

The BLLac object S4 0954+65 is one of the main targets of the Urumqi monitoring program targeting IntraDay Variable (IDV) sources. Between August 2005 and December 2009, the source was included in 41 observing sessions, carried out at a frequency of 4.8 GHz. The time analysis of the collected light curves, performed by applying both a structure function analysis and a specifically developed wavelet-based algorithm, discovered an annual cycle in the variability timescales, suggesting that there is a fundamental contribution by interstellar scintillation to the IDV pattern of the source. The combined use of the two analysis methods also revealed that there was a dramatic change in the variability characteristics of the source between February and March 2008, at the starting time of a strong outburst phase. The analysis' results suggest that the flaring state of the source coincides with the appearance of multiple timescales in its light curves, indicating that changes in the structure of the relativistically moving emitting region may strongly influence the variability observed on IDV timescales.Comment: 9 pages, 8 figures and 3 tables. Accepted for publication in Astronomy and Astrophysic

Local and non-local equivalent potentials for p-12C scattering

A Newton-Sabatier fixed energy inversion scheme has been used to equate inherently non-local p-${}^{12}$C potentials at a variety of energies to pion threshold, with exactly phase equivalent local ones. Those energy dependent local potentials then have been recast in the form of non-local Frahn-Lemmer interactions.Comment: 15 pages plus 9 figures submitted to Phys. Rev.

PMN J1838-3427: A new gravitationally lensed quasar

We report the discovery of a new double-image quasar that was found during a search for gravitational lenses in the southern sky. Radio source PMN J1838-3427 is composed of two flat-spectrum components with separation 1", flux density ratio 14:1 and matching spectral indices, in VLA and VLBA images. Ground-based BRI images show the optical counterpart (total I=18.6) is also double with the same separation and position angle as the radio components. An HST/WFPC2 image reveals the lens galaxy. The optical flux ratio (27:1) is higher than the radio value probably due to differential extinction of the components by the lens galaxy. An optical spectrum of the bright component contains quasar emission lines at z=2.78 and several absorption features, including prominent Ly-alpha absorption. The lens galaxy redshift could not be measured but is estimated to be z=0.36 +/- 0.08. The image configuration is consistent with the simplest plausible models for the lens potential. The flat radio spectrum and observed variability of PMN J1838-3427 suggest the time delay between flux variations of the components is measurable, and could thus provide an independent measurement of H_0.Comment: 23 pages, incl. 6 figures, to appear in A.J.; replaced with accepted version; minor changes to text, improved figure