Reclaiming human machine nature

Extending and modifying his domain of life by artifact production is one of the main characteristics of humankind. From the first hominid, who used a wood stick or a stone for extending his upper limbs and augmenting his gesture strength, to current systems engineers who used technologies for augmenting human cognition, perception and action, extending human body capabilities remains a big issue. From more than fifty years cybernetics, computer and cognitive sciences have imposed only one reductionist model of human machine systems: cognitive systems. Inspired by philosophy, behaviorist psychology and the information treatment metaphor, the cognitive system paradigm requires a function view and a functional analysis in human systems design process. According that design approach, human have been reduced to his metaphysical and functional properties in a new dualism. Human body requirements have been left to physical ergonomics or "physiology". With multidisciplinary convergence, the issues of "human-machine" systems and "human artifacts" evolve. The loss of biological and social boundaries between human organisms and interactive and informational physical artifact questions the current engineering methods and ergonomic design of cognitive systems. New developpment of human machine systems for intensive care, human space activities or bio-engineering sytems requires grounding human systems design on a renewed epistemological framework for future human systems model and evidence based "bio-engineering". In that context, reclaiming human factors, augmented human and human machine nature is a necessityComment: Published in HCI International 2014, Heraklion : Greece (2014

Meeting Minutes of the Committee in Detroit

Minutes of the committee in Detroit, which was organized to support Albertus C. Van Raalte and his people in making a settlement in Michigan. The meeting was held in the Presbyterian Church. Seven people were appointed to the committee: Theodore Romeyn, Shubael Conant, Rev. George Duffield, E. C. Seaman, A. S. Porter, E. P. Hastings, and J. W. Brooks. Other people in the state were designated to assist Van Raalte as needed such as Rev. O. P. Hoyt, the Hon. N. A. Balch, of the Senate, in Kalamazoo; George Young in Grand Rapids; Rev. Wm. M. Ferry and Henry Pennoyer in Grand Haven; and J. R. Kellogg and E. B. Bassett of Allegan and others. Rev. Van Raalte, in a most touching and impressive manner, expressed his gratitude for the sympathy and aid proffered to his countrymen, and his gratification at having advanced thus far in the preparatory steps for the settlement in a land where labor would meet with its reward, and civil and religious freedom be secure. S. Conant was chair of the meeting and N. A. Balch, secretary.https://digitalcommons.hope.edu/vrp_1840s/1116/thumbnail.jp

Towards a theatre of new multimodal meanings : Applying second generation cognition to directorial devising practice in theatre which responds to trauma

This PhD seeks to develop and articulate a directorial theatre practice which creates new meanings in contexts of trauma, informed by second-generation cognitive science. It is grounded in my own past experience as a physical theatre director devising new productions in context of conflict, and grew from a need to find language through which to articulate the mechanisms of multimodal meaning-making in embodied theatre practice which responds to trauma specifically. The research applies Robin Nelson’s Practice as Research methodology, adapted to an enactivist epistemology and augmented by Robert Romanyshyn’s approach to researcher-reflexivity. The research design is centred around the development of semantic and experiential knowledge through the creation of two theatre projects: the first a cross-community participatory production in Derry, Northern Ireland which examined personal and collective memories of the Troubles; and the second a professional production exploring cultural identity, created with first- and second-generation migrant theatremakers in London during lockdown. The critical framework structuring the inquiry is grounded in definitions of ‘meaning’ and ‘trauma’ which consider schema-based embodied and symbolic process to be constitutive of all perception, and which consider trauma to be a breakdown in schema organisation at the level of self and world. This framework is applied as a lens to dialogue the PaR with two relevant areas of scholarship: trauma and performance studies, and cognitive theatre studies. Overall, the research evidences the ways that new-meaning creation through schema co-updating and transformation is facilitated and achieved in contexts of trauma through multimodal forms of theatre practice, and indicates that more research at this intersection is warranted. The thesis offers recommendations to theatre practitioners through a ‘Points of Departure’ document which describes key methods and synthesises learning from the inquiry

Wearable Knee Health Rehabilitation Assessment using Acoustical Emissions

Each year, approximately 200,000 Americans endure anterior cruciate ligament (ACL) tears, and 100,000 reconstructive procedures are conducted to repair the injured knees (1). The injury itself, and the long rehabilitation process that follows, can majorly disrupt the quality of life for these Americans through missed workdays, reduction of overall physical activity, and increased risk of re-injury in future activities. Wearable technologies for quantifying the state of rehabilitation, and providing feedback to the user regarding which activities or intensities of activities are safe to perform at any given time, could potentially help accelerate the rehabilitation process as well as reduce the risk of re-injury. Our lab has developed a novel, wearable sensing system based on miniature piezoelectric contact microphones for measuring the acoustical emissions from the knee during movements such as unloaded flexion / extension, sit-to-stand, and walking activities. The system consists of two Knowles BU-23173 contact microphones (Knowles, Itasca, IL) positioned on the medial and lateral sides of the patella, connected to custom, analog pre-amplifier circuits and a microcontroller for digitization and data storage on a secure digital (SD) card. In addition to the acoustical sensing, the system includes two integrated inertial measurement sensors including accelerometer and gyroscope modalities to enable joint angle calculations; these sensors, with digital outputs, are connected directly to the same microcontroller via serial peripheral interface (SPI). The system provides low noise, accurate joint acoustical emission and angle measurements in a wearable form factor, and has several hours of battery life. We have also taken measurements from healthy subjects, and athletes following acute ACL tear, to determine initial features from these acoustical emissions that are associated with injured versus healthy joints. We have found that the main acoustic clicks during particular motions occurred at consistent joint angles for healthy subjects based on intraclass correlation coefficient analysis (ICC(1,1) = 0.94 and ICC(1,k) = 0.99) (2). For one subject with an ACL tear, we found that the consistency of the joint acoustical emissions was lower for the injured knee as compared to the healthy knee in the recording immediately following the injury (\u3c 7 days), and improved following six months of rehabilitation. We envision using the wearable system we have recently completed to conduct further experiments with subjects following acute ACL tears, and tracking the progress of the rehabilitation while simultaneously measuring acoustical emissions in the context of particular movements. This data will then serve as a foundation for creating subject-specific algorithms for assessing rehabilitation and providing feedback to the users

Synergistic effects of the invasive Chinese tallow (Triadica sebifera) and climate change on aquatic amphibian survival

Changes in climate and the introduction of invasive species are two major stressors to amphibians, although little is known about the interaction between these two factors with regard to impacts on amphibians. We focused our study on an invasive tree species, the Chinese tallow (Triadica sebifera), that annually sheds its leaves and produces leaf litter that is known to negatively impact aquatic amphibian survival. The purpose of our research was to determine whether the timing of leaf fall from Chinese tallow and the timing of amphibian breeding (determined by weather) influence survival of amphibian larvae. We simulated a range of winter weather scenarios, ranging from cold to warm, by altering the relative timing of when leaf litter and amphibian larvae were introduced into aquatic mesocosms. Our results indicate that amphibian larvae survival was greatly affected by the length of time Chinese tallow leaf litter decomposes in water prior to the introduction of the larvae. Larvae in treatments simulating warm winters (early amphibian breeding) were introduced to the mesocosms early in the aquatic decomposition process of the leaf litter and had significantly lower survival compared with cold winters (late amphibian breeding), likely due to significantly lower dissolved oxygen levels. Shifts to earlier breeding phenology, linked to warming climate, have already been observed in many amphibian taxa, and with most climate models predicting a significant warming trend over the next century, the trend toward earlier breeding should continue if not increase. Our results strongly suggest that a warming climate can interact with the effects of invasive plant species, in ways we have not previously considered, to reduce the survival of an already declining group of organisms

Selective Constraints on Amino Acids Estimated by a Mechanistic Codon Substitution Model with Multiple Nucleotide Changes

Empirical substitution matrices represent the average tendencies of substitutions over various protein families by sacrificing gene-level resolution. We develop a codon-based model, in which mutational tendencies of codon, a genetic code, and the strength of selective constraints against amino acid replacements can be tailored to a given gene. First, selective constraints averaged over proteins are estimated by maximizing the likelihood of each 1-PAM matrix of empirical amino acid (JTT, WAG, and LG) and codon (KHG) substitution matrices. Then, selective constraints specific to given proteins are approximated as a linear function of those estimated from the empirical substitution matrices. Akaike information criterion (AIC) values indicate that a model allowing multiple nucleotide changes fits the empirical substitution matrices significantly better. Also, the ML estimates of transition-transversion bias obtained from these empirical matrices are not so large as previously estimated. The selective constraints are characteristic of proteins rather than species. However, their relative strengths among amino acid pairs can be approximated not to depend very much on protein families but amino acid pairs, because the present model, in which selective constraints are approximated to be a linear function of those estimated from the JTT/WAG/LG/KHG matrices, can provide a good fit to other empirical substitution matrices including cpREV for chloroplast proteins and mtREV for vertebrate mitochondrial proteins. The present codon-based model with the ML estimates of selective constraints and with adjustable mutation rates of nucleotide would be useful as a simple substitution model in ML and Bayesian inferences of molecular phylogenetic trees, and enables us to obtain biologically meaningful information at both nucleotide and amino acid levels from codon and protein sequences.Comment: Table 9 in this article includes corrections for errata in the Table 9 published in 10.1371/journal.pone.0017244. Supporting information is attached at the end of the article, and a computer-readable dataset of the ML estimates of selective constraints is available from 10.1371/journal.pone.001724

Symbols in Wittgenstein's Tractatus

This paper is concerned with the status of a symbol in Wittgenstein’s Tractatus. It is claimed in the first section that a Tractarian symbol, whilst essentially a syntactic entity to be distinguished from the mark or sound that is its sign, bears its semantic significance only inessentially. In the second and third sections I pursue this point of exegesis through the Tractarian discussions of nonsense and the context principle respectively. The final section of the paper places the forgoing work in a secondary context, addressing in particular a debate regarding the realism of the Tractatus

Phosphorus mobilizing consortium Mammoth P enhances plant growth

Global agricultural productivity may be constrained by the finite and limited supply of phosphorus (P), adding to the challenges in meeting the projected needs of a growing human population in the coming decades. In addition, when P fertilizers are added to soils, they can become bound to soils resulting in low fertilizer efficiency. However, P-mobilizing bacteria could potentially liberate soil-bound P, resulting in a higher plant P uptake and increased yield. Bacteria can mobilize P through several mechanisms, suggesting that consortia of P-bacteria may be more effective than single species. Species diversity can have a synergistic, or non-additive, effect on ecosystem functioning ("the whole is more than the sum of its parts") but rarely is the microbial community structure intentionally managed to improve plant nutrient uptake. We investigated whether inoculation of soils with a four-species bacterial community developed to mobilize soil P could increase plant productivity. In wheat and turf trials, we found that Mammoth P was able to deliver yields equivalent to those achieved using conventional fertilizer applications. Herbs and fruits showed that the combination of fertilizer with Mammoth P significantly increased productivity -in some cases productivity doubled. Metabolites produced by the Mammoth P consortium led to increased yields in some cases, suggesting that microbial products (produced in the absence of plants) played a role in enhancing plant productivity. Results from these trials indicate substantial potential of Mammoth P to enhance P supply to plants, improving P fertilizer use-efficiency and increasing agricultural productivity. 19 Agricultural productivity may be constrained in the 21 st Century by the finite supply of global a 20 phosphorus (P), adding to the challenges in meeting the projected needs of a growing human population 21 in the coming decades. In addition, when P fertilizers are added to soils, they can become bound to soils 22 resulting in low fertilizer efficiency. However, bacteria have the ability to mobilize soil bound P through 23 several mechanisms potentially resulting in a higher plant P uptake and increased yield. Furthermore, 24 species diversity can have a synergistic effect on ecosystem functioning ("the whole is more than the sum 25 of its parts") suggesting that bacterial communities, or consortia, may be more effective than single 26 species. However, in agriculture management practices, rarely is the soil microbial community structure 27 effectively manipulated to improve plant nutrient uptake. We investigated whether inoculation of soils 28 with a bacterial consortium developed to mobilize soil P named Mammoth P could increase plant 29 productivity. In turf, herbs and fruits, we showed that the combination of conventional inorganic fertilizer 30 combined with Mammoth P increased productivity up to twofold compared to the fertilizer treatments 31 without the Mammoth P inoculant. In wheat trials, we found that Mammoth P by itself was able to deliver 32 yields equivalent to those achieved with conventional inorganic fertilizer applications. The metabolites 33 produced by the consortium in Mammoth P likely played a role in enhancing plant productivity. Results 34 from this study indicate the substantial potential of Mammoth P to enhance P supply to plants, improving 35 P fertilizer use-efficiency and increasing agricultural productivity. 3

Greenhouse gas mitigation potentials in the livestock sector

Acknowledgements This paper constitutes an output of the Belmont Forum/FACCE-JPI funded DEVIL project (NE/M021327/1). Financial support from the CGIAR Program on Climate Change, Agriculture and Food Security (CCAFS) and the EU-FP7 AnimalChange project is also recognized. P.K.T. acknowledges the support of a CSIRO McMaster Research Fellowship.Peer reviewedPostprin

High Energy Physics Opportunities Using Reactor Antineutrinos

Nuclear reactors are uniquely powerful, abundant, and flavor-pure sources ofantineutrinos that continue to play a vital role in the US neutrino physicsprogram. The US reactor antineutrino physics community is a diverse interestgroup encompassing many detection technologies and many particle physicstopics, including Standard Model and short-baseline oscillations, BSM physicssearches, and reactor flux and spectrum modeling. The community's aims offerstrong complimentary with numerous aspects of the wider US neutrino program andhave direct relevance to most of the topical sub-groups composing the Snowmass2021 Neutrino Frontier. Reactor neutrino experiments also have a directsocietal impact and have become a strong workforce and technology developmentpipeline for DOE National Laboratories and universities. This white paper,prepared as a submission to the Snowmass 2021 community organizing exercise,will survey the state of the reactor antineutrino physics field and summarizethe ways in which current and future reactor antineutrino experiments can playa critical role in advancing the field of particle physics in the next decade.<br