Randomised, controlled trial of alternating pressure mattresses compared with alternating pressure overlays for the prevention of pressure ulcers : PRESSURE (pressure relieving support surfaces) trial

Objective To compare whether differences exist between alternating pressure overlays and alternating pressure mattresses in the development of new pressure ulcers, healing of existing pressure ulcers, and patient acceptability. Design Pragmatic, open, multicentre, randomised controlled trial. Setting 11 hospitals in six NHS trusts. Participants 1972 people admitted to hospital as acute or elective patients. Interventions Participants were randomised to an alternating pressure mattress (n = 982) of- an alternating pressure overlay (n = 990). Main outcome measures The proportion of participants developing a new pressure ulcer of grade 2 or worse; time to development of new pressure ulcers; proportions of participants developing a new ulcer within 30 days; healing of existing pressure ulcers; and patient acceptability Results Intention to treat analysis found no difference in the proportions of participants developing a new pressure ulcer of grade 2 or worse (10.7% overlay patients, 10.3% mattress patients; difference 0.4%, 95% confidence interval - 23% to 3.1%, P = 0.75). More overlay patients requested change owing to dissatisfaction (23.3%) than mattress patients (18.9%, P = 0.02). Conclusion No difference was found between alternating pressure mattresses and alternating pressure overlays in the proportion of people who develop a pressure ulcer

Ultracompact monolithic integration of balanced, polarization diversity photodetectors for coherent lightwave receivers

The authors have monolithically integrated an optical front-end on InP for balanced, polarization-diversity coherent lightwave reception which is only 1.3-mm long. Low on-chip insertion loss (<4.5 dB) and balanced photoresponse (1.05:1 or better) are achieved at 1.5-μm wavelength using straightforward, regrowth-free fabrication. Low-capacitance photodetectors (≤0.15 pF) are employed for high bandwidth operation

Assessing the Privacy Risks of Data Sharing in Genomics

The protection of identity of participants in medical research has traditionally been guaranteed by the maintenance of the confidentiality of health information through mechanisms such as only releasing data in an aggregated form or after identifying variables have been removed. This protection of privacy is regarded as a fundamental principle of research ethics, through which the support of research participants and the public is maintained. Whilst this traditional model was adopted for genetics and genomics research, and was generally considered broadly fit for purpose, we argue that this approach is increasingly untenable in genomics. Privacy risk assessments need to have regard to the whole data environment, not merely the quality of the dataset to be released in isolation. As sources of data proliferate, issues of privacy protection are increasingly problematic in relation to the release of genomic data. However, we conclude that, by paying careful attention to potential pitfalls, scientific funders and researchers can take an important part in attempts to safeguard the public and ensure the continuation of potentially important scientific research

The Quasar Pair Q 1634+267 A, B and the Binary QSO vs. Dark Lens Hypotheses

Deep HST/NICMOS H (F160W) band observations of the z=1.96 quasar pair Q 1634+267A,B reveal no signs of a lens galaxy to a 1 sigma threshold of approximately 22.5 mag. The minimum luminosity for a normal lens galaxy would be a 6L_* galaxy at z > 0.5, which is 650 times greater than our detection threshold. Our observation constrains the infrared mass-to-light ratio of any putative, early-type, lens galaxy to (M/L)_H > 690h_65 (1200h_65) for Omega_0=0.1 (1.0) and H_0=65h_65 km/s/Mpc. We would expect to detect a galaxy somewhere in the field because of the very strong Mg II absorption lines at z=1.1262 in the Q 1634+267 A spectrum, but the HST H-band, I-band (F785LP) and V-band (F555W) images require that any associated galaxy be very under-luminous less than 0.1 L^*_H (1.0 L^*_I) if it lies within less than 40 h^{-1} (100 h^{-1}) kpc from Q 1634+267 A,B. While the large image separation (3.86 arcsec) and the lack of a lens galaxy strongly favor interpreting Q 1634+267A,B as a binary quasar system, the spectral similarity remains a puzzle. We estimate that at most 0.06% of randomly selected quasar pairs would have spectra as similar to each other as the spectra of Q 1634+267 A and B. Moreover, spectral similarities observed for the 14 quasar pairs are significantly greater than would be expected for an equivalent sample of randomly selected field quasars. Depending on how strictly we define similarity, we estimate that only 0.01--3% of randomly drawn samples of 14 quasar pairs would have as many similar pairs as the observational sample.Comment: 24 pages, including 4 figures, LaTex, ApJ accepted, comments from the editor included, minor editorial change

A Fast Algorithm for Robust Regression with Penalised Trimmed Squares

The presence of groups containing high leverage outliers makes linear regression a difficult problem due to the masking effect. The available high breakdown estimators based on Least Trimmed Squares often do not succeed in detecting masked high leverage outliers in finite samples. An alternative to the LTS estimator, called Penalised Trimmed Squares (PTS) estimator, was introduced by the authors in \cite{ZiouAv:05,ZiAvPi:07} and it appears to be less sensitive to the masking problem. This estimator is defined by a Quadratic Mixed Integer Programming (QMIP) problem, where in the objective function a penalty cost for each observation is included which serves as an upper bound on the residual error for any feasible regression line. Since the PTS does not require presetting the number of outliers to delete from the data set, it has better efficiency with respect to other estimators. However, due to the high computational complexity of the resulting QMIP problem, exact solutions for moderately large regression problems is infeasible. In this paper we further establish the theoretical properties of the PTS estimator, such as high breakdown and efficiency, and propose an approximate algorithm called Fast-PTS to compute the PTS estimator for large data sets efficiently. Extensive computational experiments on sets of benchmark instances with varying degrees of outlier contamination, indicate that the proposed algorithm performs well in identifying groups of high leverage outliers in reasonable computational time.Comment: 27 page

Development and evaluation of predictive models for measuring the biological integrity of streams

The ratio of the number of observed taxa to that expected to occur in the absence of human-caused stress (OIE) is an intuitive and ecologically meaningful measure of biological integrity. We examined how OIE ratios derived from stream invertebrate data varied among 234 unimpaired reference sites and 254 test sites potentially impaired by past logging. Data were collected from streams in three montane ecoregions in California. Two sets of River Invertebrate Prediction and Classification System (RIVPACS) predictive models were built: one set of models was based on near-species taxonomic resolution; the other was based on family identifications. Two models were built for each level of taxonomic resolution: one calculated 0 and E based on all taxa with probabilities of capture (PC) \u3e 0; the other calculated 0 and E based on only those taxa with PC2 0.5. Evaluations of the performance of each model were based on three criteria: (1) how well models predicted the taxa found at unimpaired sites, (2) the degree to which OIE values differed among unimpaired reference sites and potentially impaired test sites, and (3) the degree to which test site OIE values were correlated with independent measures of watershed alteration. Predictions of species models were more accurate than those of family models, and predictions of the PC2 0.5 species model were more robust than predictions of the PC2 0 model. OIE values derived from both species models were related to land use variables, but only assessments based on the PC2 0.5 model were insensitive to naturally occurring differences among streams, ecoregions, and year

The X-ray Properties of z>4 Quasars

We report on a search for X-ray emission from quasars with redshifts greater than four using the ROSAT public database. Our search has doubled the number of z>4 quasars detected in X-rays from 6 to 12. Most of those known prior to this work were radio-loud and X-ray selected sources; our study increases the number of X-ray detected, optically selected z>4 quasars from one to seven. We present their basic X-ray properties and compare these to those of lower redshift quasars. We do not find any evidence for strong broad-band spectral differences between optically selected z>4 quasars and those at lower redshifts.Comment: 7 pages, 4 figures included, LaTeX emulateapj.sty, accepted for publication in the Astronomical Journa

Spring School on Language, Music, and Cognition: Organizing Events in Time

The interdisciplinary spring school “Language, music, and cognition: Organizing events in time” was held from February 26 to March 2, 2018 at the Institute of Musicology of the University of Cologne. Language, speech, and music as events in time were explored from different perspectives including evolutionary biology, social cognition, developmental psychology, cognitive neuroscience of speech, language, and communication, as well as computational and biological approaches to language and music. There were 10 lectures, 4 workshops, and 1 student poster session. Overall, the spring school investigated language and music as neurocognitive systems and focused on a mechanistic approach exploring the neural substrates underlying musical, linguistic, social, and emotional processes and behaviors. In particular, researchers approached questions concerning cognitive processes, computational procedures, and neural mechanisms underlying the temporal organization of language and music, mainly from two perspectives: one was concerned with syntax or structural representations of language and music as neurocognitive systems (i.e., an intrapersonal perspective), while the other emphasized social interaction and emotions in their communicative function (i.e., an interpersonal perspective). The spring school not only acted as a platform for knowledge transfer and exchange but also generated a number of important research questions as challenges for future investigations