SYNTHESIS, CHARACTERIZATION AND IN VITRO MICROBIAL EVALUATION OF REGIOISOMERS OF ALLYL PHENYL ETHERS DERIVED 1, 2, 4-TRIAZOLES

Objective: Synthesis and antimicrobial evaluation of regioisomers of allyl phenyl ethers derived 1, 2, 4-triazoles. Methods: A series of new 1,2,4-triazole derivatives of allyl phenyl ethers were synthesized by reacting a mixture of regio isomers 1-(3-bromo-2-methoxypropoxy)-arene and 1-(2-bromo-3-methoxypropoxy)-arene with 1,2,4-triazole in presence of K2CO3 and DMF at 80oC in good yields. Allyl phenyl ethers 1(a-f) were synthesized by refluxing the substituted phenols with allyl bromide in the presence of K2CO3 and acetone in excellent yields. The newly synthesized compounds were characterized by IR, 1HNMR, Mass spectral studies and elemental analysis. These compounds were also screened for their In-vitro antibacterial and antifungal activities. Results: Allyl phenyl ethers derived 1,2,4-triazol derivatives were synthesized in good yields. Conclusion: Preliminary results revealed that some of the synthesized compounds were showed promising antibacterial and antifungal activity

Evidence for widespread hydrated minerals on asteroid (101955) Bennu

Early spectral data from the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission reveal evidence for abundant hydrated minerals on the surface of near-Earth asteroid (101955) Bennu in the form of a near-infrared absorption near 2.7 µm and thermal infrared spectral features that are most similar to those of aqueously altered CM-type carbonaceous chondrites. We observe these spectral features across the surface of Bennu, and there is no evidence of substantial rotational variability at the spatial scales of tens to hundreds of metres observed to date. In the visible and near-infrared (0.4 to 2.4 µm) Bennu’s spectrum appears featureless and with a blue (negative) slope, confirming previous ground-based observations. Bennu may represent a class of objects that could have brought volatiles and organic chemistry to Earth

The dynamic geophysical environment of (101955) Bennu based on OSIRIS-REx measurements

The top-shaped morphology characteristic of asteroid (101955) Bennu, often found among fast-spinning asteroids and binary asteroid primaries, may have contributed substantially to binary asteroid formation. Yet a detailed geophysical analysis of this morphology for a fast-spinning asteroid has not been possible prior to the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission. Combining the measured Bennu mass and shape obtained during the Preliminary Survey phase of the OSIRIS-REx mission, we find a notable transition in Bennu’s surface slopes within its rotational Roche lobe, defined as the region where material is energetically trapped to the surface. As the intersection of the rotational Roche lobe with Bennu’s surface has been most recently migrating towards its equator (given Bennu’s increasing spin rate), we infer that Bennu’s surface slopes have been changing across its surface within the last million years. We also find evidence for substantial density heterogeneity within this body, suggesting that its interior is a mixture of voids and boulders. The presence of such heterogeneity and Bennu’s top shape are consistent with spin-induced failure at some point in its past, although the manner of its failure cannot yet be determined. Future measurements by the OSIRIS-REx spacecraft will provide insight into and may resolve questions regarding the formation and evolution of Bennu’s top-shape morphology and its link to the formation of binary asteroids

Microwave induced Friedlander condensation A facile synthesis of 1,8-naphthyridines

215-217A simple and efficient method has been developed for the rapid synthesis of 1,8-naphthyridines 3 from 2-aminonicotinaldehyde 1 and active methylene compounds 2 in methanol in the presence of a catalytic amount of piperidine in unmodified domestic microwave oven in unsealed borosil vessels. The reaction time has been brought down from hours to minutes with improved yields using microwave irradiation

Microwave assisted heterocyclization: A rapid and efficient synthesis of 1,8-naphthyridinyl-1 ,3,4-oxadiazoles

2124-21255-Aryl-2-[4-(3-phenyl-1,8-naphthyridin-2-ylamino)phenyl]-1,3,4-oxadiazoles 4 have been synthesized by the reaction or 2-(4-carboxyphenylamino)-3-phenyl-1,8-naphthyridine 3 with aromatic acid hydrazides in the presence of POCl3 under microwave irradiation and by conventional methods arc described. The reaction rate is enhanced tremendously under microwave irradiation as compared to conventional method with improved yields

Potassium triiodide catalyzed Friedlander synthesis of 1,8-naphthyridines in aqueous media

253-255 Potassium triiodide catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing -methylene group 2 in aqueous media to afford 1,8-naphthyridines 3 in high yields. </smarttagtype

Mild and Efficient Oxidation of Pyrazolinyl-1,8-naphthyridines to Pyrazolyl-1,8-naphthyridines Mediated by Cerium(IV) Ammonium Nitrate under Microwave Irradiation.

2618-2621Cerium (IV ) ammonium nitrate (CAN) has been used as an effective oxidizing agent for the oxidation of pyrazolinyl-1,8- naphthyridines 3 to the corresponding pyrazolyl-1,8-naphthyridines 4 under microwave irradiation with high yields

Synthesis of some novel azetidino[2,3-<i>b</i>][1,8]naphthyridin-2(1<i>H</i>)-ones and 1,2,4-triazolo [4,3<i>-a</i>][1,8] naphthyridines

1746-1749Ethyl 1,8-naphthyridin-2-one-3-carboxylate 1 on fusion with different anilines at 200°C affords N-aryl-1,8-naphthyridin-2-one-3-carboxamides 2, which undergo smooth cyclization with POCl3 yielding 1-arylazetidino [2,3-b][1,8]naphthyrid in-2(1H)-ones 3.Compound 1 on treatment with POCl3 yield ethyl 2-chloro-1,8-naphthyridine-3-carboxylate 4, which on reaction with aromatic acid hydrazides in methanol furnishes respective N-aroyl-N'-(3- carbethoxy-1,8-naphthyridin-2-yl) hydrazines 5. Cyclization of 5 with POCl3 under reflux result in the formation of 1-aryl-4-carbethoxy-1,2,4-triazolof [4,3-a][1,8] naphthyridines 6. Compounds 3 and 6 have been evaluated for their antibacterial activity using streptomycin as a reference compound