KUALITAS SELAI YANG DIOLAH DARI RUMPUT LAUT, Graci/aria verrucosa, Eucheuma cottonii, SERTA CAMPURAN KEDUANYA = THE QUALITY OF JAM PROCESSED FROM SEAWEEDS, Graci/aria verrucosa, , Eucheuma cottonii AND ITS COMBINATIONS

The aims of this research were to investigate the physical, chemical and organoleptic quality of jam that processed from 3 different seaweeds raw material. Materials that used in this research were Gracilaria venvcosa, Eucheuma cottonii and its combination. Seaweeds were boiled, blended, mixed with sugar and stirred for 20 minutes and jams are packaged. The experimental design applied was Completely Randomized Design with 3 treatments and each treatments were triplicates. Data on moisture content, sugar content, crude fiber, pH, water activity, viscosity and sensory evaluation were tested with analyzes of variance. The HSD test was conducted in order to determine the differences among treatments. While sensory evaluation data were analyzed by using Kruskall Wallis test. Based on the results, moisture content of combination jam were significantly different (P&#88040.05) from E. cottoniijam, but it did not significantlydifferent (P>0.05) to G. venvcosa jam. Water activity of combination jam showed there were significantly different (P&#88040.05) from E. cottonii jam, but it did not significantly different (P>0.05) to G. venvcosa jam. While, between G. venvcosa and E. cottonii showed did not significantly different (P>0.05). For pH value, sugar content, and crude fiber content showed did not significantly different (P>0.05). There were highly significant different (P&#88040.01) on the viscosity of E. cottonii jam from G. venvcosa jam, and it was significantly different (P&#88040.05) to its combination jam. While, viscosity of its combination jam did not significantly different (P>0.05) from G. ve"ucosa jam. The sensory evaluation (color,texture, taste and odor) results indicated that there were significant differences (P&#88040.05) among treatments. However the spreads characteristic showed did not significantly different (P>0.05)

Pengaruh Lama Fermentasi Terhadap Kualitas Kecap Keong Sawah (Pila Ampullacea)

Keong sawah dapat dijadikan sumber protein lokal yang baik bagi tubuh, keberadaannya sangat melimpah sehingga keong sawah dapat digunakan sebagai sumber nutrisi yang baik bagi kebutuhan tubuh manusia. Pengolahannya yang masih sangat sederhana membuat keong sawah kurang menarik untuk dikonsumsi. Tujuan dari penelitian ini adalah untuk mengetahui kadar garam terbaik pada pembuatan kecap keong sawah secara enzimatis dan untuk mengetahui lama fermentasiterbaik sehingga dihasilkan kecap asin keong sawah dengan kualitas baik dan disukai konsumen. Metode penelitian yang digunakan bersifat experimental laboratories dengan Rancangan Acak Lengkap (RAL). Penelitian dilakukan dalam dua tahap, pada tahap pertama dilakukan penambahan kadar garam 10%, 15% dan 20%. Dari perlakuan tersebut, didapatkan konsentrasi 20% sebagai penambahan kadar garam terbaik yang masih dapat diterima secara hedonik. Pada tahap kedua, dilakukan perlakuan lama fermentasi 5 hari, 10 hari dan 15 hari pada pembuatan kecap keong sawah, kemudian kecap keong sawah dilakukan pengujian nilai amino nitrogen, kadar air, kadar Pb, pH, hedonik dengan masing-masing tiga kali pengulangan. Data dianalisis menggunakan analisa ragam (ANOVA). Hasil penelitian menunjukkan bahwa lama fermentasi memberikan pengaruh berbeda nyata (p<0,05) terhadap semua parameter uji. Lama fermentasi 15 hari menjadi lama fermentasi terbaik dengan amino protein 3,42%, kadar air 82,15%, nilai kadar Pb 0,18%, nilai pH 5,58 dan nilai rata-rata hedonik 7,56

Cash Turnover, Debt to Asset Ratio, Current Ratio dan Net Profit Margin terhadap ROE Perusahaan Konstruksi yang Terdaftar di BEI

ABSTRACT This study aims to analyze the effect of Cash Turnover, liabilities on assets, current ratios, and net profit margins on the return on capital of construction companies listed on the BEI. This research method is quantitative, because the data used is numerical. The population of this survey reached 18 construction companies listed on the Indonesia Stock Exchange. The survey sample used in the form of financial statements of 10 construction companies listed on the IDX in 2016 to 2020. The type of data used in this research activity is secondary data, which was taken through the IDX official website (www.idx.co.id). The results show that the results of the T test are, a) the Cash Turnover variable has a t-count value of 3.279 > 2.026 and a significance value of 0.001 <0.05: b) the Debt to Assets Ratio variable has a t-count value of 5.348 > 2.026 and a significance value of 0.002 <0 ,05; c) the Current Ratio variable has a t value of - 0.424 < 2.026 and a significance value of 0.674 > 0.05; d) the Net Profit Margin variable has a t-count value of 1.636 < 2.026 and a significance value of 0.110 > 0.05. Also, the results of the F test show the calculated F value (24.172)>F table (2.69) with a significance value of <0.05. Conclusions, a) Cash Turnover (CT) has a significant effect on the value of companies in the Construction industry listed on the IDX in 2016-2020; b) Debt To Equity Ratio (DER) has a significant effect on the value of companies in the Construction industry listed on the IDX in 2016-2020; c) Current Ratio (CT) does not affect the value of companies in the Construction industry listed on the IDX in 2016-2020; d) Net Profit Margin (NPM) has no effect on the value of companies in the Construction industry listed on the IDX in 2016-2020. Keywords: Cash Turnover, Debt to Asset Ratio, Current Ratio, Net Profit Margin Return on Equit

KUALITAS SELAI YANG DIOLAH DARI RUMPUT LAUT, Gracilaria verrucosa, Eucheuma cottonii, SERTA CAMPURAN KEDUANYA

The aims of this research were to investigate the physical, chemical and organoleptic quality of jam that processed from 3 different seaweeds raw material. Materials that used in this research were Gracilaria verrucosa, Eucheuma cottonii and its combination. Seaweeds were boiled, blended, mixed with sugar and stirred for 20 minutes and jams are packaged. The experimental design applied was Completely Randomized Design with 3 treatments and each treatments were triplicates. Data on moisture content, sugar content, crude fi ber, pH, water activity, viscosity and sensory evaluation were tested with analyzes of variance. The HSD test was conducted in order to determine the differences among treatments. While sensory evaluation data were analyzed by using Kruskall Wallis test. Based on the results, moisture content of combination jam were significantly different (P0.05) to G. verrucosa jam. Water activity of combination jam showed there were significantly different (P0.05) to G. verrucosa jam. While, between G. verrucosa and E. cottonii showed did not significantly different (P>0.05). For pH value, sugar content, and crude fi ber content showed did not significantly different (P>0.05). There were highly signifi cant different (P0.05) from G. verrucosa jam. The sensory evaluation (color, texture, taste and odor) results indicated that there were signifi cant differences (P0.05)

Time resolution of the plastic scintillator strips with matrix photomultiplier readout for J-PET tomograph

Recent tests of a single module of the Jagiellonian Positron Emission Tomography system (J-PET) consisting of 30 cm long plastic scintillator strips have proven its applicability for the detection of annihilation quanta (0.511 MeV) with a coincidence resolving time (CRT) of 0.266 ns. The achieved resolution is almost by a factor of two better with respect to the current TOF-PET detectors and it can still be improved since, as it is shown in this article, the intrinsic limit of time resolution for the determination of time of the interaction of 0.511 MeV gamma quanta in plastic scintillators is much lower. As the major point of the article, a method allowing to record timestamps of several photons, at two ends of the scintillator strip, by means of matrix of silicon photomultipliers (SiPM) is introduced. As a result of simulations, conducted with the number of SiPM varying from 4 to 42, it is shown that the improvement of timing resolution saturates with the growing number of photomultipliers, and that the 2 x 5 configuration at two ends allowing to read twenty timestamps, constitutes an optimal solution. The conducted simulations accounted for the emission time distribution, photon transport and absorption inside the scintillator, as well as quantum efficiency and transit time spread of photosensors, and were checked based on the experimental results. Application of the 2 x 5 matrix of SiPM allows for achieving the coincidence resolving time in positron emission tomography of $\approx$ 0.170 ns for 15 cm axial field-of-view (AFOV) and $\approx$ 0.365 ns for 100 cm AFOV. The results open perspectives for construction of a cost-effective TOF-PET scanner with significantly better TOF resolution and larger AFOV with respect to the current TOF-PET modalities.Comment: To be published in Phys. Med. Biol. (26 pages, 17 figures

Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads

The sequence and assembly of human genomes using long-read sequencing technologies has revolutionized our understanding of structural variation and genome organization. We compared the accuracy, continuity, and gene annotation of genome assemblies generated from either high-fidelity (HiFi) or continuous long-read (CLR) datasets from the same complete hydatidiform mole human genome. We find that the HiFi sequence data assemble an additional 10% of duplicated regions and more accurately represent the structure of tandem repeats, as validated with orthogonal analyses. As a result, an additional 5 Mbp of pericentromeric sequences are recovered in the HiFi assembly, resulting in a 2.5-fold increase in the NG50 within 1 Mbp of the centromere (HiFi 480.6 kbp, CLR 191.5 kbp). Additionally, the HiFi genome assembly was generated in significantly less time with fewer computational resources than the CLR assembly. Although the HiFi assembly has significantly improved continuity and accuracy in many complex regions of the genome, it still falls short of the assembly of centromeric DNA and the largest regions of segmental duplication using existing assemblers. Despite these shortcomings, our results suggest that HiFi may be the most effective standalone technology for de novo assembly of human genomes

FDG PET/CT in carcinoma of unknown primary

Carcinoma of unknown primary (CUP) is a heterogeneous group of metastatic malignancies in which a primary tumor could not be detected despite thorough diagnostic evaluation. Because of its high sensitivity for the detection of lesions, combined 18F-fluoro-2-deoxyglucose positron emission tomography (FDG PET)/computed tomography (CT) may be an excellent alternative to CT alone and conventional magnetic resonance imaging in detecting the unknown primary tumor. This article will review the use, diagnostic performance, and utility of FDG PET/CT in CUP and will discuss challenges and future considerations in the diagnostic management of CUP

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV