Características morfológicas y estructura superficial de montículos submarinos del talud inferior del margen continental canario (O de las Islas Canarias)

Extrusive edifices and structural reliefs, catalogued as mounds and located on the seafloor to the west of Canary Islands were analyzed by acoustic data obtained with multibeam and parametric echosounders during several oceanographic expeditions. They were carried out at deep waters, from 4800 to 5200 m, and they have allowed characterizing 41 newly discovered submarine structures which occur either as isolated edifices or clustered mounds. These features have circular to elongated shapes with diameters of 2-24 km and relief heights of 10 to 250 m, showing different flank slopes of 2-50°. They generally display mounded forms and show morphological elements as ridges, near-circular rock outcrops, depressions and fault scarps together with mass flow and slide deposits located at the vicinity of the edifices. Two types of extrusive features are evidenced by the morphological and seismic data analyses, the first one probably corresponds to high velocity extrusions that reach the seafloor surface and the second one is probably formed by the combination of faulted structures and low velocity extrusions that produce singular domes in the shallower sedimentary records. Based on both analyses, extrusive phenomena represent the dominant mechanism for mound field evolution in the Canary lower slope region.Versión del edito

Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction-stir bar sorptive extraction-derivatization and gas chromatography-mass spectrometry

This work describes the development, optimiza- tion, and validation of a new method for the simultaneous determination of a wide range of pharmaceuticals (beta- blockers, lipid regulators ... ) and personal care products (fragrances, UV filters, phthalates ... ) in both aqueous and solid environmental matrices. Target compounds were extracted from sediments using pressurized hot water ex- traction followed by stir bar sorptive extraction. The first stage was performed at 1,500 psi during three static extrac- tion cycles of 5 min each after optimizing the extraction temperature (50 – 150 °C) and addition of organic modifiers (% methanol) to water, the extraction solvent. Next, aqueous extracts and water samples were processed using polydime- thylsiloxane bars. Several parameters were optimized for this technique, including extraction and desorption time, ionic strength, presence of organic modifiers, and pH. Fi- nally, analytes were extracted from the bars by ultrasonic irradiation using a reduced amount of solvent (0.2 mL) prior to derivatization and gas chromatography – mass spectrome- try analysis. The optimized protocol uses minimal amounts of organic solvents (<10 mL/sample) and time ( ≈ 8 h/sam- ple) compared to previous ex isting methodologies. Low standard deviation (usually below 10 %) and limits of de- tection (sub-ppb) vouch for the applicability of the method- ology for the analysis of target compounds at trace levels. Once developed, the method was applied to determin

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

The MAX network transcriptional repressor (MNT) is an MXD family transcription factor of the basic helix-loop-helix (bHLH) family. MNT dimerizes with another transcriptional regulator, MYC-associated factor X (MAX), and down-regulates genes by binding to E-boxes. MAX also dimerizes with MYC, an oncogenic bHLH transcription factor. Upon E-box binding, the MYC-MAX dimer activates gene expression. MNT also binds to the MAX dimerization protein MLX (MLX), and MNT-MLX and MNT-MAX dimers co-exist. However, all MNT functions have been attributed to MNT-MAX dimers, and no functions of the MNT-MLX dimer have been described. MNT's biological role has been linked to its function as a MYC oncogene modulator, but little is known about its regulation. We show here that MNT localizes to the nucleus of MAX-expressing cells and that MNT-MAX dimers bind and repress the MNT promoter, an effect that depends on one of the two E-boxes on this promoter. In MAX-deficient cells, MNT was overexpressed and redistributed to the cytoplasm. Interestingly, MNT was required for cell proliferation even in the absence of MAX. We show that in MAX-deficient cells, MNT binds to MLX, but also forms homodimers. RNA-sequencing experiments revealed that MNT regulates the expression of several genes even in the absence of MAX, with many of these genes being involved in cell cycle regulation and DNA repair. Of note, MNT-MNT homodimers regulated the transcription of some genes involved in cell proliferation. The tight regulation of MNT and its functionality even without MAX suggest a major role for MNT in cell proliferation.This work was supported by Grant SAF2017-88026-R from Agencia Estatal de Investigación, Spanish Government (to J. L. and M. D. D.), funded in part by FEDER Program from the European Union, National Institutes of Health Grant CA57138/CA from NCI (to R. N. E.), and grants from Shriners Hospitals for Children (to P. J. H.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

Características geomorfológicas del Pasaje de Lanzarote (Región oriental de las Islas Canarias)

The Passage of Lanzarote is an example of a wide oceanic corridor. It extends between the eastern Canary Islands and the Western Africa continental margin. Seafloor morphology of this passage has been analyzed with the aim to know the morphogenetic processes related to both the oceanography and the geology. Multibeam bathymetric data and high and very high resolution seismic profiles obtained in the SUBVENT2 cruise have been used. Five main morphological groups were analyzed: (a) Volcanic or diapiric submarine hills; (b) Tectonic features on the continental slope (linear scarps and a rhomboid-like depression) related to normal faults at the top of buried diapirs; (c) Giant circular depressions initially triggered by submarine venting at the top of diapirs; (d) Sedimentary instabilities and canyons (gullies, canyons, mass transport deposits) that are present specially on the Fuerteventura-Lanzarote ridge must be related to the high energy geological processes, both constructive and dismantling, associated to the evolution of these volcanic domains; and (e) Contouritic features both erosive (central channel, contourite channels) and depositional (mounded and plastered drifts) that occur in the central part of the bottom surface of the passage, and are generated by the interaction of the MW and the interface MW-AAIW with the seafloor.Versión del edito

Modified magnetic anisotropy at LaCoO_(3)/La_(0.7)Sr_(0.3)MnO_(3) interfaces

Controlling magnetic anisotropy is an important objective towards engineering novel magnetic device concepts in oxide electronics. In thin film manganites, magnetic anisotropy is weak and it is primarily determined by the substrate, through induced structural distortions resulting from epitaxial mismatch strain. On the other hand, in cobaltites, with a stronger spin orbit interaction, magnetic anisotropy is typically much stronger. In this paper, we show that interfacing La0.7Sr0.3MnO3 (LSMO) with an ultrathin LaCoO3 (LCO) layer drastically modifies the magnetic anisotropy of the manganite, making it independent of the substrate and closer to the magnetic isotropy characterizing its rhombohedral structure. Ferromagnetic resonance measurements evidence a tendency of manganite magnetic moments to point out-of-plane suggesting non collinear magnetic interactions at the interface. These results may be of interest for the design of oxide interfaces with tailored magnetic structures for new oxide devices

Micro-morphologies, habitats and associated biodiversity in a fluid venting submarine structure using ROV underwater images: Mercator mud volcano (Gulf of Cádiz)

Mercator mud volcano has been explored by direct visual observations using a ROV at 350 to 370 m depth. Underwater images, taken mainly at the summit, have allowed characterizing the fluid venting environment, where different microforms, habitats and associated biota, with typical seepage components have been identified. Chemosynthetic bacterial communities were detected and sampled at the northeastern side of the summit at 350 m, next to pockmark-like depressions with diameters ranging 1 to 3 m, bioturbation marks, sediment mounds and authigenic carbonates of different sizes (0.1-5m length). Chemosynthesis-based communities were mainly composed by bacterial mats (patch diameter 10-30 cm), however some remains of cold seep chemosymbiotic bivalves (Lucinoma asapheus) were also found on the sediment. Habitat types at Mercator MV are influenced by oceanographic and sedimentation processes deposition and favouring fauna colonizing diverse substrate types, such as large sponges on slabs and sea-pens and annelids on soft bottoms

Respiratory viruses detected in Mexican children younger than 5 years old with community-acquired pneumonia: a national multicenter study

Background: Acute respiratory infections are the leading cause of mortality in children worldwide, especially in developing countries. Pneumonia accounts for 16% of all deaths of children under 5 years of age and was the cause of death of 935 000 children in 2015. Despite its frequency and severity, information regarding its etiology is limited. The aim of this study was to identify respiratory viruses associated with community-acquired pneumonia (CAP) in children younger than 5 years old. Methods: One thousand four hundred and four children younger than 5 years of age with a clinical and/or radiological diagnosis of CAP in 11 hospitals in Mexico were included. Nasal washes were collected, placed in viral medium, and frozen at �70 C until processing. The first 832 samples were processed using the multiplex Bio-Plex/Luminex system and the remaining 572 samples using the Anyplex multiplex RT-PCR. Clinical data regarding diagnosis, clinical signs and symptoms, radiographic pattern, and risk factors were obtained and recorded. Results: Of the samples tested, 81.6% were positive for viruses. Respiratory syncytial virus (types A and B) was found in 23.7%, human enterovirus/rhinovirus in 16.6%, metapneumovirus in 5.7%, parainfluenza virus (types 1–4) in 5.5%, influenza virus (types A and B) in 3.6%, adenovirus in 2.2%, coronavirus (NL63, OC43, 229E, and HKU1) in 2.2%, and bocavirus in 0.4%. Co-infection with two or more viruses was present in 22.1%; 18.4% of the samples were negative. Using biomass for cooking, daycare attendance, absence of breastfeeding, and co-infections were found to be statistically significant risk factors for the presence of severe pneumonia. Conclusions: Respiratory syncytial virus (types A and B), human enterovirus/rhinovirus, and metapneumovirus were the respiratory viruses identified most frequently in children younger than 5 years old with CAP. Co-infection was present in an important proportion of the children

Triggering Mechanisms of Tsunamis in the Gulf of Cadiz and the Alboran Sea: An Overview

The Gulf of Cadiz and the Alboran Sea are characterized by tectonic activity due to oblique convergence at the boundary between the Eurasian and Nubian plates. This activity has favoured a variety of tsunamigenic sources: basically, seismogenic faults and submarine landslides. The main tsunamigenic faults in the Gulf of Cadiz would comprise the thrust systems of Gorringe Ridge, Marquês de Pombal, São Vicente Canyon, and Horseshoe faults with a high susceptibility; meanwhile in the Alboran Sea would be the thrust system of the northern Alboran Ridge with high susceptibility, and the thrust systems of north Xauen and Adra margin, the transpressive segment of Al Idrissi fault, and the Yusuf-Habibas and Averroes faults, with moderate to high susceptibility. The areas with the greatest potential to generate tsunamigenic submarine landslides are in the Gulf of Cadiz, the São Vicente Canyon, Hirondelle Seamount, and Gorringe Ridge; and in the Alboran Sea are the southern and northern flanks of Alboran Ridge. Both sources are likely to generate destructive tsunamis in the Gulf of Cadiz, given its history of bigger earthquakes (>7 Mw) and larger landslides. To fully assess tsunamigenic sources, further work needs to be performed. In the case of seismogenic faults, research focuses on geometry, offsets, timing, paleoearthquakes, and recurrence, and in landslides on early post-failure evolution, age, events, and recurrence. In situ measurements, paleotsunami records, and long-term monitoring, in addition to major modelling developments, will be also necessary.Versión del edito