COCO: A Platform for Comparing Continuous Optimizers in a Black-Box Setting

We introduce COCO, an open source platform for Comparing Continuous Optimizers in a black-box setting. COCO aims at automatizing the tedious and repetitive task of benchmarking numerical optimization algorithms to the greatest possible extent. The platform and the underlying methodology allow to benchmark in the same framework deterministic and stochastic solvers for both single and multiobjective optimization. We present the rationales behind the (decade-long) development of the platform as a general proposition for guidelines towards better benchmarking. We detail underlying fundamental concepts of COCO such as the definition of a problem as a function instance, the underlying idea of instances, the use of target values, and runtime defined by the number of function calls as the central performance measure. Finally, we give a quick overview of the basic code structure and the currently available test suites.Comment: Optimization Methods and Software, Taylor & Francis, In press, pp.1-3

Profiling Metacognition in Binge Eating Disorder

© 2020, The Author(s). Research has shown that metacognition may play a role in problem eating. In this study we explored whether aspects of metacognition are relevant to the understanding of binge eating in patients with Binge Eating Disorder. We aimed to ascertain: (1) the presence of metacognitive beliefs about binge eating; (2) the goal of, and stop signal for, binge eating; and (3) the impact of binge eating on self-consciousness. Ten Binge Eating Disorder patients took part in the study and were assessed using the metacognitive profiling semi-structured interview. Results suggested that all patients endorsed both positive and negative metacognitive beliefs about binge eating. The goals of binge eating were stop thinking about personal concerns and improve emotional state. All patients reported that they did not know when these goals had been reached. The stop signals for binge eating included physical discomfort, beliefs about binge eating not being the best way to solve problems, and environmental stimuli. All patients also confirmed that a reduction in self-consciousness occurred during a binge eating episode. The results of this study confirm that metacognition may indeed be relevant to the understanding of Binge Eating Disorder

Espondilodiscitis en la infancia

La espondilodiscitis es una enfermedad inflamatoria que afecta el disco intervertebral y los cuerpos vertebrales adyacentes. Esta afección cursa con gran variedad de síntomas, relacionados con la edad del paciente y la localización del proceso inflamatorio. Se presentan 3 casos de discitis en niños pequeños que manifestaron síntomas diversos tales como: dificultad en la marcha, rechazo a caminar o sentarse, lumbalgia y dolor abdominal. Todos presentaron hiperlordosis lumbo-sacra. La centellografía resultó el examen complementario de elección para definir el diagnóstico al demostrar hipercaptación a nivel del disco intervertebral. La antibioticoterapia endovenosa fue curativa. Se propone al dosaje de proteína C reactiva como parámetro de laboratorio útil para el seguimiento.Spondylodiscitis is an inflammatory disease that affects the intervertebral disk and adjacent vertebral bodies. This affection develops a wide variety of symptoms related to the patient´s age and the inflammatory process location. We are reporting three children of early age with discitis who presented a range of symptoms such as: walking difficulties, refusal to walk or sit, low back pain and abdominal pain. Lumbosacral hyperlordosis was present in all cases. Scintigraphy was the complementary method of choice to define the diagnosis by showing hypercaptatation at the invertebral disk level. Endovenous antibiotic therapy proved effective. We propose the dosage of C protein as a useful laboratory parameter for the follow-up of these patients

Cold atoms in micromachined waveguides: A new platform for atom-photon interactions

Hybrid quantum devices, incorporating both atoms and photons, can exploit the benefits of both to enable scalable architectures for quantum computing and quantum communication, as well as chip-scale sensors and single-photon sources. Production of such devices depends on the development of an interface between their atomic and photonic components. This should be compact, robust, and compatible with existing technologies from both fields. Here we demonstrate such an interface. Cold cesium atoms are trapped inside a transverse, 30μm-diameter through hole in an optical fiber, created via laser micromachining. When the guided light is on resonance with the cesium D2 line, up to 87% of it is absorbed by the atoms. The corresponding optical depth per unit length is ∼700 cm−1, higher than any reported for a comparable system. This is important for miniaturization and scalability. The technique can be equally effective in optical waveguide chips and other existing photonic systems, providing a promising platform for fundamental research

Methodologies for determining staffing needs in healthcare: systematic literature review

The determination of staffing needs in healthcare is not just calculating the optimal number of professionals but is defining how the professional contingent accompanies the development of the healthcare organisation and of the population’s care needs. This research investigates the existence of a gold standard for determining health personnel requirements. We perform a systematic literature review to explore several approaches worldwide, examining a wide range of contextual variables, useful for the definition of an omni-comprehensive approach. A total of 557 articles was initially detected, then reduced to 57 after excluding everything not related to healthcare context and staff planning models. Results do not reveal a recognized standard for determining staffing needs. Approaches to the definition of staffing standards are mainly ex-ante (31%), based on the characteristics of specific models and organisational needs, or ex-post (62%), based on production analysis and historical trends. Most of these refer to the medical and nursing category (68.4%), while the minority proposes a multi-professional approach (17.5%). This review highlights innovative approaches based on algorithms which, starting from historical data, are adjusted by moderating key variables such as contextual factors, healthcare organisation models and professional attributes. The review suggests: 1. Develop and share a unique tool for defining standards based on several variables that identify the characteristics of the context 2. Use up-to-date information flows and quality data 3. Consider a multi-professional approach 4. Adopt a long-term vision and continuous dialogue with the training process It is clear the need to develop a tool for the definition of personnel requirements in line with internal and external changes in the health system. Therefore, such models need to account for an adequate number of variables, useful to identify the characteristics of the overall context. Key messages: The development of staffing needs estimates must necessarily rely on a certain level of standardisation, but at the same time must take into account the variability characterising different contexts. In order to respond to recent demographic and epidemiological trends, it is crucial to include in the model skill mix and task shifting strategies involving health professionals as a whole

Alimentos contra el cáncer oral

El cáncer oral representa el 5% de todas las neoplasias y el 30% de los cánceres de cabeza y cuello. El porcentaje de supervivencia a los 5 años es de tan sólo el 25%, por lo que el diagnóstico y tratamiento precoces pueden salvar muchas vidas. La mayoría de los cánceres se relacionan con factores externos al organismo (tabaco, alcohol, betel, dieta y radiaciones solares, principalmente), que pueden modificarse o evitarse, es decir, prevenibles. Alrededor del 35% de los casos de cáncer están relacionados con la alimentación. Por este motivo, es importante que los profesionales de la salud informen a sus pacientes acerca de las enormes posibilidades profilácticas de la dieta. El objetivo de este trabajo de actualización bibliográfica es destacar la importancia de una alimentación saludable para la prevención del cáncer oral

The coevolutionary biology of brood parasitism : a call for integration

Obligate brood-parasitic cheats have fascinated natural historians since ancient times. Passing on the costs of parental care to others occurs widely in birds, insects and fish, and often exerts selection pressure on hosts that in turn evolve defences. Brood parasites have therefore provided an illuminating system for researching coevolution. Nevertheless, much remains unknown about howecology and evolutionary history constrain or facilitate brood parasitism, or the mechanisms that shape or respond to selection. In this special issue, we bring together examples fromacross the animal kingdomto illustrate the diverseways in which recent research is addressing these gaps. This special issue also considers how research on brood parasitism may benefit from, and in turn inform, related fields such as social evolution and immunity. Here, we argue that progress in our understanding of coevolution would benefit from the increased integration of ideas across taxonomic boundaries and across Tinbergen's Four Questions: mechanism, ontogeny, function and phylogeny of brood parasitism. We also encourage renewed vigour in uncovering the natural history of the majority of the world's brood parasites that remain little-known. Indeed, it seems very likely that some of nature's brood parasites remain entirely unknown, because otherwise we are left with a puzzle: if parental care is so costly, why is brood parasitism not more common? This article is part of the theme issue 'The coevolutionary biology of brood parasitism: from mechanism to pattern'.Non peer reviewe

L'usage des systèmes d'informations électroniques en recherche scientifique : le cas de la neurophysiologie.

Nous présentons les premiers résultats d'une enquête destinée à mieux connaître les pratiques de recherche d'information bibliographique et documentaire chez les chercheurs scientifiques. 64 chercheurs et étudiants doctorants en neurophysiologie ont répondu à un questionnaire portant sur les méthodes, les outils, et les objectifs des recherches d'information typiques dans leur activité. De plus, 11 personnes parmi les répondants ont participé à un entretien individuel semi structuré. Il en ressort que l'usage d'outils informatisés de recherche d'information bibliographique (RIB) est désormais pratique courante, au détriment des index et autres sources imprimées. Les principaux outils utilisés sont la base de données bibliographiques PubMed et le moteur de recherche Google, avec toutefois de nombreux autres outils plus spécifiques utilisés à titre complémentaire. Les répondants mentionnent des objectifs très variés, comme l'acquisition de connaissances nouvelles, mais aussi la recherche de techniques expérimentales, la veille documentaire, l'alimentation du débat scientifique, ou l'aide à l'enseignement. Les difficultés que rencontrent les experts en neurosciences intégratives dans l'exploitation des outils informatiques de RIB spécialisés semblent surtout liées à l'absence de formation des experts à ces outils. Les chercheurs définissent l'outil informatique de RIB « idéal » comme fiable et exhaustif, mais aussi rapide et facile à utiliser et apprendre . De fait, le facteur temps apparaît déterminant dans leur choix d'utilisation ou non d'un outil particulier. Cette étude ouvre la voie à des expériences plus spécifiques, qui porteront sur les stratégies cognitives des experts dans ce type de tâches

Design optimization of a contact-aided continuum robot for endobronchial interventions based on anatomical constraints

PURPOSE: A laser-profiled continuum robot (CR) with a series of interlocking joints has been developed in our center to reach deeper areas of the airways. However, it deflects with constant curvature, which thus increases the difficulty of entering specific bronchi without relying on the tissue reaction forces. This paper aims to propose an optimization framework to find the best design parameters for nonconstant curvature CRs to reach distal targets while attempting to avoid the collision with the surrounding tissue. METHODS: First, the contact-aided compliant mechanisms (CCMs) are integrated with the continuum robot to achieve the nonconstant curvature. Second, forward kinematics considering CCMs is built. Third, inverse kinematics is implemented to steer the robot tip toward the desired targets within the confined anatomy. Finally, an optimization framework is proposed to find the best robot design to reach the target with the least collision to the bronchi walls. RESULTS: Experiments are carried out to verify the feasibility of CCMs to enable the nonconstant curvature deflection, and simulations demonstrate a lower cost function value to reach a target for the nonconstant curvature optimized design with respect to the standard constant curvature robot (0.11 vs. 2.66). In addition, the higher capacity of the optimized design to complete the task is validated by interventional experiments using fluoroscopy. CONCLUSION: Results demonstrate the effectiveness of the proposed framework to find an optimized CR with nonconstant curvature to perform safer interventions to reach distal targets

A sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle

Abstract The bulk of body fat in mammals is in the form of triacylglycerol. Diacylglycerol O-acyltransferase 2 (DGAT2) catalyses the terminal step in triacylglycerol synthesis. The proximity of DGAT2 with stearoyl-CoA desaturase (SCD) in the endoplasmic reticulum may facilitate provision of de novo SCD-mediated fatty acids as substrate for DGAT2. Here, we first searched for sequence variants in the DGAT2 gene to then validate their effect on fat content and fatty acid composition in muscle, subcutaneous fat and liver of 1129 Duroc pigs. A single nucleotide polymorphism in exon 9 (ss7315407085 G > A) was selected as a tag variant for the 33 sequence variants identified in the DGAT2 region. The DGAT2-G allele increased DGAT2 expression in muscle and had a positive impact on muscular C14 and C16 fatty acids at the expense of C18 fatty acids. Although there was no evidence for an interaction of DGAT2 with functional SCD genotypes, pigs carrying the DGAT2-G allele had proportionally more palmitoleic acid relative to palmitic acid. Our findings indicate that DGAT2 preferentially uptakes shorter rather than longer-chain fatty acids as substrate, especially if they are monounsaturated, and confirm that fatty acid metabolism in pigs is subjected to subtle tissue-specific genetic regulatory mechanisms