Coping with multiple adversities: Men who sought medico-legal care because of physical violence from a partner or ex-partner.

Objectives: To describe male victims of physical violence by an intimate partner who consulted a medico-legal unit, and information available on their perpetrators; to characterize the violent events and their contexts. Little research exists on male victims of physical intimate partner violence seeking medical care. Method: Based on Heise’s ecological framework, mixed methods were used to analyze quantitative and qualitative data collected during 122 medico-legal consultations attended by 115 men who sustained physical violence by an intimate partner from 2006–2012. Results: Quantitative and quantitative data collected from male victims concurred in showing that many of such victims, as well as their partners, faced at the time of the assault multiple adversities and challenges at individual and relationship levels. Among male victims, 26% had no paid job. Among perpetrators, 34% were third-country nationals subject to restricted residence permits. Health issues, worries about money or work combined with complex and conflictive family situations were often in the background of violent events. In a few cases, however, male victims reported no other problems than their partner’s assault. Conclusions: Our findings point out gender-specific aspects of female-to-male physical partner violence. The most common feature is that violence was experienced as one among several adversities. Even though wounds sustained by male victims were not necessarily severe, their emotional suffering was frequent. When underage children were involved, their situation was particularly noteworthy. Interventions with male victims of intimate partner violence should include protection of minors as a priority and as an incentive for fathers to seek help

La prévention et le sexting : un état des lieux

Le développement social et relationnel des adolescent-e-s et des jeunes adultes s’effectue aujourd’hui avec celui d’Internet et des nouvelles technologies. Dans ce contexte, les interactions et la transmission d’informations numériques sont facilitées et peu restreintes, ce qui peut mener à un certain nombre d’enjeux en termes d’usage des technologies et de gestion de l’image numérique. Le sexting fait partie de ces problématiques. Cette pratique pouvant, de manière générale, se définir comme l’échange électronique de matériel personnel à caractère sexuel ou intime, peut parfois mener à des situations dramatiques lorsque, par exemple, le contenu d’un message est transféré sans consentement à d’autres personnes. Après avoir mené une première recherche exploratoire qualitative sur la pratique du sexting chez les jeunes, la thématique de la prévention relative au sexting s’est avérée particulièrement intéressante à approfondir. En effet, très peu de jeunes ont rapporté se rappeler de messages ou campagnes de prévention autour du sexting spécifiquement. Au vu de ces résultats, nous avons considéré qu’il était essentiel d’établir un état des lieux de l’offre préventive sur la thématique du sexting, plus particulièrement dans le canton de Vaud, afin de vérifier les dires de certains jeunes sur le manque d’intervention et de discussion sur le sexting et ses possibles dérives. A travers cet état des lieux et ce rapport, nous proposons donc un catalogue permettant de répertorier et d’offrir une vue d’ensemble des différents acteurs-trices et ressources à disposition dans le cadre de la prévention relative à la pratique du sexting auprès des jeunes

Magnetic parameters as proxies for anthropogenic pollution in water reservoir sediments from Mexico: an interdisciplinary approach

We assess the element pollution level of water reservoir sediments using environmental magnetism techniques as a novel approach. Although “La Purísima” Water Reservoir is an important source for multiple activities (e.g. recreational, fishing and agricultural) in Guanajuato state, it has been receiving for the last centuries a high load of pollutants by mining extraction, urbanization and land-use change from the Guanajuato Hydrological Basin. The analyses of environmental magnetism, geochemistry, X-ray energy dispersive spectroscopy, scanning electron microscopy and multivariate methods were applied to study sediments from the reservoir and basin. Accordingly, they indicate the presence of iron oxides (magnetite and hematite) and iron sulfides (pyrite and greigite), which evidences relevant differences in particle size and concentration within the water reservoir (median mass-specific magnetic susceptibility χ = 23.2 × 10−8 m3/kg), as well as with respect to the river basin sediments (median χ = 88.8 × 10−8 m3/kg). The highest enrichment factor EF values (median values of EF = 2–10 for As, Co, Ba, Cu, Cd, Ni and EF > 20 for S) are mainly associated with historical mining activities that have led to an enrichment of potentially toxic elements on these water reservoir sediments. We propose the use of concentration and grain size dependent magnetic parameters, i.e. χ, remanent magnetizations and anhysteretic ratios ARM/SIRM and χARM/χ, as proxies for Ba, Co, Cr, Ni, P and Pb pollution in these river and water reservoir sediments. Such parameters allow to evaluate this sedimentary environment, and similar ones, through useful and convenient proxies.Fil: Chaparro, Marcos Adrián Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; ArgentinaFil: Ramírez Ramírez, Margarita. Universidad de Guanajuato. División Ciencias de la Vida; MéxicoFil: Chaparro, Mauro Alejandro Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; ArgentinaFil: Miranda Avilés, Raúl. Universidad de Guanajuato; MéxicoFil: Puy Alquiza, María Jesús. Universidad de Guanajuato; MéxicoFil: Böhnel, Harald N.. Universidad Nacional Autónoma de México. Centro de Geociencias; MéxicoFil: Zanor, Gabriela Ana. Universidad de Guanajuato. División Ciencias de la Vida; Méxic

Low-Mass Star Formation, Triggered by Supernova in Primordial Clouds

The evolution of a gas shell, swept by the supernova remnant of a massive first generation star, is studied with H_2 and HD chemistry taken into account. When a first-generation star explodes as a supernova, H_2 and HD molecules are formed in the swept gas shell and effectively cool the gas shell to temperatures of 32 K - 154 K. If the supernova remnant can sweep to gather the ambient gas, the gas shell comes to be dominated by its self-gravity, and hence, is expected to fragment. Our result shows that for a reasonable range of temperatures (200 K - 1000 K) of interstellar gas, the formation of second-generation stars can be triggered by a single supernova or hypernova.Comment: 38pages, 10 figures, The Astrophysical Journal, accepted 8 Dec. 200

Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells

Heme biosynthesis begins in the mitochondrion with the formation of delta-aminolevulinic acid (ALA). In acute intermittent porphyria, hereditary tyrosinemia type I and lead poisoning patients, ALA is accumulated in plasma and in organs, especially the liver. These diseases are also associated with neuromuscular dysfunction and increased incidence of hepatocellular carcinoma. Many studies suggest that this damage may originate from ALA-induced oxidative stress following its accumulation. Using the MnSOD as an oxidative stress marker, we showed here that ALA treatment of cultured cells induced ROS production, increasing with ALA concentration. The mitochondrial energetic function of ALA-treated HepG2 cells was further explored. Mitochondrial respiration and ATP content were reduced compared to control cells. For the 300 μM treatment, ALA induced a mitochondrial mass decrease and a mitochondrial network imbalance although neither necrosis nor apoptosis were observed. The up regulation of PGC-1, Tfam and ND5 genes was also found; these genes encode mitochondrial proteins involved in mitochondrial biogenesis activation and OXPHOS function. We propose that ALA may constitute an internal bioenergetic signal, which initiates a coordinated upregulation of respiratory genes, which ultimately drives mitochondrial metabolic adaptation within cells. The addition of an antioxidant, Manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), resulted in improvement of maximal respiratory chain capacity with 300 μM ALA. Our results suggest that mitochondria, an ALA-production site, are more sensitive to pro-oxidant effect of ALA, and may be directly involved in pathophysiology of patients with inherited or acquired porphyria

Constraining decaying dark energy density models with the CMB temperature-redshift relation

We discuss the thermodynamic and dynamical properties of a variable dark energy model with density scaling as $\rho_x \propto (1+z)^{m}$, z being the redshift. These models lead to the creation/disruption of matter and radiation, which affect the cosmic evolution of both matter and radiation components in the Universe. In particular, we have studied the temperature-redshift relation of radiation, which has been constrained using a recent collection of cosmic microwave background (CMB) temperature measurements up to $z \sim 3$. We find that, within the uncertainties, the model is indistinguishable from a cosmological constant which does not exchange any particles with other components. Future observations, in particular measurements of CMB temperature at large redshift, will allow to give firmer bounds on the effective equation of state parameter $w_{eff}$ for such types of dark energy models.Comment: 9 pages, 1 figure, to appear in the Proceedings of the 3rd Italian-Pakistani Workshop on Relativistic Astrophysics, Lecce 20-22 June 2011, published in Journal of Physics: Conference Series (JPCS

Enfants exposés à la violence dans le couple parental : étude rétrospective des données récoltées auprès de 430 mères et pères de 654 enfants âgés de 0 à 17 ans, lorsque ces parents avaient consulté l’Unité de médecine des violences du CHUV suite à un événement violent dans le couple survenu entre 2011 et 2014

[Préface (extraits)] L'étude menée par l'équipe de l'Unité de médecine des violences (UMV) entrouvre la porte de la chambre des enfants, afin d’amener un éclairage supplémentaire sur la nature et les circonstances de l’exposition des enfants à la violence dans le couple parental. Elle montre comment les enfants sont directement concernés dans la violence qui a lieu dans leur foyer. Souvent atteints psychiquement et physiquement, il n'est pas rare qu'ils aillent jusqu’à s'interposer au milieu de ces rapports de violence en se mettant eux-mêmes en danger lorsqu’ils prennent la défense de la victime, le plus souvent d'ailleurs leur mère. Dans d'autres cas, ils et elles intériorisent les modèles genrés d'auteur ou de victime auprès desquels ils grandissent et puisent leur identité. Les prérequis favorables à une transmission intergénérationnelle de la violence dans le couple sont renforcés par cette immersion quotidienne

Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over

Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base. Methods: The IEMO 80-plus thyroid trial was explicitly designed as an ancillary experiment to the Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism randomised placebo controlled Trial (TRUST) with a near identical protocol and shared research infrastructure. Outcomes will be presented separately for the IEMO and TRUST 80-plus groups, as well as a pre-planned combined analysis of the 145 participants included in the IEMO trial and the 146 participants from the TRUST thyroid trial aged 80 years and over. The IEMO 80-plus thyroid trial is a multi-centre randomised double-blind placebo-controlled parallel group trial of levothyroxine treatment in community-dwelling participants aged 80 years and over with persistent subclinical hypothyroidism (TSH ≥4.6 and ≤ 19.9 mU/L and fT4 within laboratory reference ranges). Participants are randomised to levothyroxine 25 or 50 micrograms daily or matching placebo with dose titrations according to TSH levels, for a minimum follow-up of one and a maximum of three years. Primary study endpoints: hypothyroid physical symptoms and tiredness on the thyroid-related quality of life patient-reported outcome (ThyPRO) at one year. Secondary endpoints: generic quality of life, executive cognitive function, handgrip strength, functional ability, blood pressure, weight, body mass index, and mortality. Adverse events will be recorded with specific interest on cardiovascular endpoints such as atrial fibrillation and heart failure. Discussion: The combined analysis of participants in the IEMO 80-plus thyroid trial with the participants aged over 80 in the TRUST trial will provide the largest experimental evidence base on multimodal effects of levothyroxine treatment in 80-plus persons to date

Source parameters of the great Sumatran megathrust earthquakes of 1797 and 1833 inferred from coral microatolls

Large uplifts and tilts occurred on the Sumatran outer arc islands between 0.5° and 3.3°S during great historical earthquakes in 1797 and 1833, as judged from relative sea level changes recorded by annually banded coral heads. Coral data for these two earthquakes are most complete along a 160-km length of the Mentawai islands between 3.2° and 2°S. Uplift there was as great as 0.8 m in 1797 and 2.8 m in 1833. Uplift in 1797 extended 370 km, between 3.2° and 0.5°S. The pattern and magnitude of uplift imply megathrust ruptures corresponding to moment magnitudes (M_w) in the range 8.5 to 8.7. The region of uplift in 1833 ranges from 2° to at least 3.2°S and, judging from historical reports of shaking and tsunamis, perhaps as far as 5°S. The patterns and magnitude of uplift and tilt in 1833 are similar to those experienced farther north, between 0.5° and 3°N, during the giant Nias-Simeulue megathrust earthquake of 2005; the outer arc islands rose as much as 3 m and tilted toward the mainland. Elastic dislocation forward modeling of the coral data yields megathrust ruptures with moment magnitudes ranging from 8.6 to 8.9. Sparse accounts at Padang, along the mainland west coast at latitude 1°S, imply tsunami runups of at least 5 m in 1797 and 3–4 m in 1833. Tsunamis simulated from the pattern of coral uplift are roughly consistent with these reports. The tsunami modeling further indicates that the Indian Ocean tsunamis of both 1797 and 1833, unlike that of 2004, were directed mainly south of the Indian subcontinent. Between about 0.7° and 2.1°S, the lack of vintage 1797 and 1833 coral heads in the intertidal zone demonstrates that interseismic submergence has now nearly equals coseismic emergence that accompanied those earthquakes. The interseismic strains accumulated along this reach of the megathrust have thus approached or exceeded the levels relieved in 1797 and 1833