The role of anti-malarial drugs in eliminating malaria

Effective anti-malarial drug treatment reduces malaria transmission. This alone can reduce the incidence and prevalence of malaria, although the effects are greater in areas of low transmission where a greater proportion of the infectious reservoir is symptomatic and receives anti-malarial treatment. Effective treatment has greater effects on the transmission of falciparum malaria, where gametocytogenesis is delayed, compared with the other human malarias in which peak gametocytaemia and transmissibility coincides with peak asexual parasite densities. Mature Plasmodium falciparum gametocytes are more drug resistant and affected only by artemisinins and 8-aminoquinolines. The key operational question now is whether primaquine should be added to artemisinin combination treatments for the treatment of falciparum malaria to reduce further the transmissibility of the treated infection. Radical treatment with primaquine plays a key role in the eradication of vivax and ovale malaria. More evidence is needed on the safety of primaquine when administered without screening for G6PD deficiency to inform individual and mass treatment approaches in the context of malaria elimination programmes

Chemical and biological processes for nutrients removal and recovery

This chapter gives an overview on the main technologies for nutrient removal from industrial wastewater by focusing on principles and operational parameters of real applications. A plethora of technologies can achieve the nutrients removal from wastewater depending mainly on their concentration and forms; however, biological nitrification and denitrification and chemical precipitation are the most common processes used today to remove nitrogen and phosphorus, respectively. Stripping, adsorption and membrane based processes for nutrients recovery can be economically viable only when nitrogen concentration is higher than 1.5-2 gN/L. On the other hand, phosphorus recovery should always be pursued and struvite crystalization is the most common option that should be evaluated together with biological phosphorus accumulation in sludge or plants for the following post-processing and valorization

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regulation could therefore provide valuable mechanistic insights. We have now mapped and examined the function of human islet cis-regulatory networks. We identify genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and show that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains. We find that sequence variants associated with type 2 diabetes and fasting glycemia are enriched in these clustered islet enhancers and identify trait-associated variants that disrupt DNA binding and islet enhancer activity. Our studies illustrate how islet transcription factors interact functionally with the epigenome and provide systematic evidence that the dysregulation of islet enhancers is relevant to the mechanisms underlying type 2 diabetes

Crisis and interest: the political economy of think tanks during the great recession

This article analyzes the inputs and constituencies (funding, founders, trustees, and experts) of the most influential group of think tanks in Spain during the great recession (2008-2015) in order to assess how far these think tanks were connected to other interest groups providing support for neoliberal policies. The aim of the article is to advance knowledge on think tank theory and it addresses three research goals: (a) assessing how far Spanish think tanks are affected by political clientelism and financialization, (b) identifying those actors who direct Spanish think tanks and collaborate with them, and (c) assessing the think tanks’ connections with international lobbying networks. Our results show that the think tanks studied are consistently related to three types of actor—political, economic, and academic—while also maintaining strong ties with the media. In this regard, their main traits are a pluralism biased toward right and center-left stances, state and party clientelism, the financial and political instrumentalization of party tanks, and the superior ability of conservative tanks to build network coalitions.The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Spanish Ministry for Economy and Innovation under Grant ECO2012-34490 (a 3-year R+D project for 2013-2016)

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.

Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regulation could therefore provide valuable mechanistic insights. We have now mapped and examined the function of human islet cis-regulatory networks. We identify genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and show that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains. We find that sequence variants associated with type 2 diabetes and fasting glycemia are enriched in these clustered islet enhancers and identify trait-associated variants that disrupt DNA binding and islet enhancer activity. Our studies illustrate how islet transcription factors interact functionally with the epigenome and provide systematic evidence that the dysregulation of islet enhancers is relevant to the mechanisms underlying type 2 diabetes