Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula?

Background: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake. Method: A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet. Nutritional intake where HF was used was compared to those without HF, with or without a vitamin and mineral supplement (VMS). Results: One-hundred-and-five food diaries were included in the data analysis: 70 boys (66.7%) with median age of 21.8 months [IQR: 10 - 67.7]. Fifty-three children (50.5%) consumed a HF and the volume of consumption was correlated to micronutrient intake. Significantly (p <0.05) more children reached their micronutrient requirements if a HF was consumed. In those without a HF, some continued not to achieve requirements in particular for vitamin D and zinc, in spite of VMS. Conclusion: This study points towards the important micronutrient contribution of a HF in children with FPIGA. Children, who are not on a HF and without a VMS, are at increased risk of low intakes in particular vitamin D and zinc. Further studies need to be performed, to assess whether dietary intake translates into actual biological deficiencies

Super Abrasive Machining of Integral Rotary Components Using Grinding Flank Tools

Manufacturing techniques that are applied to turbomachinery components represent a challenge in the aeronautic sector. These components require high resistant super-alloys in order to satisfy the extreme working conditions they have to support during their useful life. Besides, in the particular case of Integrally Bladed Rotors (IBR), usually present complex geometries that need to be roughed and finished by milling and grinding processes, respectively. In order to improve their manufacturing processes, Super Abrasive Machining (SAM) is presented as a solution because it combines the advantages of the use of grinding tools with milling feed rates. However, this innovative technique usually needed high tool rotary speed and pure cutting oils cooling. These issues implied that SAM technique was not feasible in conventional machining centers. In this work, these matters were tackled and the possibility of using SAM in these five-axis centers with emulsion coolants was achieved. To verify this approach, Inconel 718 single blades with non-ruled surfaces were manufactured with Flank-SAM technique and conventional milling process, analyzing cutting forces, surface roughness, and dimension accuracy in both cases. The results show that SAM implies a suitable, controllable, and predictable process to improve the manufacture of aeronautical critical components, such as IBR.FEDE

Cardiovascular disease behavioral risk factors among Latinos by citizenship and documentation status.

BACKGROUND:Studies have observed that recent Latino immigrants tend to have a physical health advantage compared to immigrants who have been in the US for many years or Latinos who are born in the United States. An explanation of this phenomenon is that recent immigrants have positive health behaviors that protect them from chronic disease risk. This study aims to determine if trends in positive cardiovascular disease (CVD) risk behaviors extend to Latino immigrants in California according to citizenship and documentation status. METHODS:We examined CVD behavioral risk factors by citizenship/documentation statuses among Latinos and non-Latino US-born whites in the 2011-2015 waves of the California Health Interview Survey. Adjusted multivariable logistic regressions estimated the odds for CVD behavioral risk factors, and analyses were stratified by sex. RESULTS:In adjusted analyses, using US-born Latinos as the reference group, undocumented Latino immigrants had the lowest odds of current smoking, binge drinking, and frequency of fast food consumption. There were no differences across the groups for fruit/vegetable intake and walking for leisure. Among those with high blood pressure, undocumented immigrants were least likely to be on medication. Undocumented immigrant women had better patterns of CVD behavioral risk factors on some measures compared with other Latino citizenship and documentation groups. CONCLUSIONS:This study observes that the healthy Latino immigrant advantage seems to apply to undocumented female immigrants, but it does not necessarily extend to undocumented male immigrants who had similar behavioral risk profiles to US-born Latinos

<i>In vitro - in vivo </i>relations for the parenteral liposomal formulation of Amphotericin B:A clinically relevant approach with PBPK modeling

In vitro release testing is a useful tool for the quality control of controlled release parenteral formulations, but in vitro release test conditions that reflect or are able to predict the in vivo performance are advantageous. Therefore, it is important to investigate the factors that could affect drug release from formulations and relate them to in vivo performance. In this study the effect of media composition including albumin presence, type of buffer and hydrodynamics on drug release were evaluated on a liposomal Amphotericin B formulation (Ambisome®). A physiologically based pharmacokinetic (PBPK) model was developed using plasma concentration profiles from healthy subjects, in order to investigate the impact of each variable from the in vitro release tests on the prediction of the in vivo performance. It was found that albumin presence was the most important factor for the release of Amphotericin B from Ambisome®; both hydrodynamics setups, coupled with the PBPK model, had comparable predictive ability for simulating in vivo plasma concentration profiles. The PBPK model was extrapolated to a hypothetical hypoalbuminaemic population and the Amphotericin B plasma concentration and its activity against fungal cells were simulated. Selected in vitro release tests for these controlled release parenteral formulations were able to predict the in vivo AmB exposure, and this PBPK driven approach to release test development could benefit development of such formulations.</p

Constant probe orientation for fast contact-based inspection of 3D free-form surfaces using (3+2)-axis inspection machines

A new probe optimization method for contact based (3+2)-axis inspection machines is proposed. Given an inspection path of a stylus on a free-form surface, an optimal orientation of the stylus is computed such that (i) the inclination angle of the stylus is within a given angular range with respect to the surface normal, (ii) the motion of the stylus is globally collision free, and (iii) the stylus remains constant in the coordinate system of the measuring machine. The last condition guarantees that the inspection motion requires only the involvement of the three translational axes of the measuring machine. The numerical simulations were validated through physical experiments on a testcase of a tooth of a bevel gear due to the surface complexity and probe accessibility. This optimized method was compared to 3-axis and 5-axis inspection strategies, showing that the fixed (3+2)-axis stylus returns more accurate inspection results compared to the traditional 3-axis approach and similar to 5-axis approach.RYC-2017-2264

Cost analysis of the management of brain metastases in patients with advanced ALK+ NSCLC: alectinib versus crizotinib

Aim: To estimate management cost of NSCLC ALK+ patients with and without brain metastasis (BM), and to compare annual costs in patients treated with alectinib or crizotinib. Methods: Management cost/year (euro 2018) in patients with and without BM was estimated with disaggregated resource consumption provided by local oncologists, including medical visits, hospitalizations, diagnostic/laboratory tests, imaging techniques and surgical procedures. The comparison of costs/year with alectinib and crizotinib, considered the cumulative 12-month incidence of BM in ALEX trial (9.4 and 41.4%, respectively). Results: Management cost was euro6173.42/patient-year without BM and euro21,637.50/patient-year with BM. With alectinib, average cost/patient was lower than crizotinib (euro4948.51/patient-year). Conclusion: Prevention of BM with alectinib may result in reductions of cost/year in the management of advanced ALK+ NSCLC

Constant probe orientation for fast contact-based inspection of 3D free-form surfaces using (3+2)-axis inspection machines

A new probe optimization method for contact based (3+2)-axis inspection machines is proposed. Given an inspection path of a stylus on a free-form surface, an optimal orientation of the stylus is computed such that (i) the inclination angle of the stylus is within a given angular range with respect to the surface normal, (ii) the motion of the stylus is globally collision free, and (iii) the stylus remains constant in the coordinate system of the measuring machine. The last condition guarantees that the inspection motion requires only the involvement of the three translational axes of the measuring machine. The numerical simulations were validated through physical experiments on a testcase of a tooth of a bevel gear due to the surface complexity and probe accessibility. This optimized method was compared to 3-axis and 5-axis inspection strategies, showing that the fixed (3+2)-axis stylus returns more accurate inspection results compared to the traditional 3-axis approach and similar to 5-axis approach

Diabetic Macular Edema Characterization and Visualization Using Optical Coherence Tomography Images

Diabetic Retinopathy and Diabetic Macular Edema (DME) represent one of the main causes of blindness in developed countries. They are characterized by fluid deposits in the retinal layers, causing a progressive vision loss over the time. The clinical literature defines three DME types according to the texture and disposition of the fluid accumulations: Cystoid Macular Edema (CME), Diffuse Retinal Thickening (DRT) and Serous Retinal Detachment (SRD). Detecting each one is essential as, depending on their presence, the expert will decide on the adequate treatment of the pathology. In this work, we propose a robust detection and visualization methodology based on the analysis of independent image regions. We study a complete and heterogeneous library of 375 texture and intensity features in a dataset of 356 labeled images from two of the most used capture devices in the clinical domain: a CIRRUSTM HD-OCT 500 Carl Zeiss Meditec and 179 OCT images from a modular HRA + OCT SPECTRALIS(R) from Heidelberg Engineering, Inc. We extracted 33,810 samples for each type of DME for the feature analysis and incremental training of four different classifier paradigms. This way, we achieved an 84.04% average accuracy for CME, 78.44% average accuracy for DRT and 95.40% average accuracy for SRD. These models are used to generate an intuitive visualization of the fluid regions. We use an image sampling and voting strategy, resulting in a system capable of detecting and characterizing the three types of DME presenting them in an intuitive and repeatable way

CD-62°1346: An extreme halo or hypervelocity CH star?

High-velocity halo stars provide important information about the properties of the extreme Galactic halo. The study of unbound and bound Population II stars permits us to better estimate the mass of the halo. Aims: We carried out a detailed spectroscopic and kinematic study and have significantly refined the distance and the evolutionary state of the star. Methods: Its atmospheric parameters, chemical abundances and kinematical properties were determined using high-resolution optical spectroscopy and employing the local-thermodynamic-equilibrium model atmospheres of Kurucz and the spectral analysis code moog. Results: We found that CD-62°1346 is a metal-poor ([Fe/H] = -1.6) evolved giant star with Teff = 5300 K and log g = 1.7. The star exhibits high carbon and s-element abundances typical of CH stars. It is also a lead star. Our kinematic analysis of its 3D space motions shows that this star has a highly eccentric (e = 0.91) retrograde orbit with an apogalactic distance of ~100 kpc, exceeding by a factor of two the distance of the Magellanic Clouds. The star travels with very high velocity relative to the Galactocentric reference frame (VGRF = 570 km s-1). Conclusions: CD-62°1346 is an evolved giant star and not a subgiant star, as was considered earlier. Whether it is bound or unbound to the Galaxy depends on the assumed mass and on the adopted Galactic potential. We also show that the star HD 5223 is another example of a high-velocity CH star that exceeds the Galactic escape velocity. Possible origins of these two high-velocity stars are briefly discussed. CD-62°1346 and HD 5223 are the first red giant stars to join the restricted group of hypervelocity stars.Fil: Pereira, C. B.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Jilinski, E.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Universidade do Estado de Rio do Janeiro; Brasil. Russian Academy of Sciences. Pulkovo Observatory; RusiaFil: Drake, N. A.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Russian Academy of Sciences. Pulkovo Observatory; RusiaFil: de Castro, D. B.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Ortega, V. G.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Chavero, Carolina Andrea. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Roig, Fernando Virgilio. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasi