551 research outputs found
Low doses of a neonicotinoid insecticide modify pheromone response thresholds of central but not peripheral olfactory neurons in a pest insect
Insect pest management relies mainly on neurotoxic insecticides, including neonicotinoids, leaving residues in the environment. There is now evidence that low doses of insecticides can have positive effects on pest insects by enhancing various life traits. Because pest insects often rely on sex pheromones for reproduction, and olfactory synaptic transmission is cholinergic, neonicotinoid residues could modify chemical communication. We recently showed that treatments with different sublethal doses of clothianidin could either enhance or decrease behavioural sex pheromone responses in the male moth, Agrotis ipsilon. We investigated now effects of the behaviourally active clothianidin doses on the sensitivity of the peripheral and central olfactory system. We show with extracellular recordings that both tested clothianidin doses do not influence pheromone responses in olfactory receptor neurons. Similarly, in vivo optical imaging does not reveal any changes in glomerular response intensities to the sex pheromone after clothianidin treatments. The sensitivity of intracellularly recorded antennal lobe output neurons, however, is upregulated by a lethal dose 20 times and downregulated by a dose 10 times lower than the lethal dose 0. This correlates with the changes of behavioural responses after clothianidin treatment and suggests the antennal lobe as neural substrate involved in clothianidin-induced behavioural changes
The contamination of the surface of Vesta by impacts and the delivery of the dark material
The Dawn spacecraft observed the presence of dark material, which in turn
proved to be associated with OH and H-rich material, on the surface of Vesta.
The source of this dark material has been identified with the low albedo
asteroids, but it is still a matter of debate whether the delivery of the dark
material is associated with a few large impact events, to micrometeorites or to
the continuous, secular flux of impactors on Vesta. The continuous flux
scenario predicts that a significant fraction of the exogenous material
accreted by Vesta should be due to non-dark impactors likely analogous to
ordinary chondrites, which instead represent only a minor contaminant in the
HED meteorites. We explored the continuous flux scenario and its implications
for the composition of the vestan regolith, taking advantage of the data from
the Dawn mission and the HED meteorites. We used our model to show that the
stochastic events scenario and the micrometeoritic flux scenario are natural
consequences of the continuous flux scenario. We then used the model to
estimate the amounts of dark and hydroxylate materials delivered on Vesta since
the LHB and we showed how our results match well with the values estimated by
the Dawn mission. We used our model to assess the amount of Fe and siderophile
elements that the continuous flux of impactors would mix in the vestan
regolith: concerning the siderophile elements, we focused our attention on the
role of Ni. The results are in agreement with the data available on the Fe and
Ni content of the HED meteorites and can be used as a reference frame in future
studies of the data from the Dawn mission and of the HED meteorites. Our model
cannot yet provide an answer to the fate of the missing non-carbonaceous
contaminants, but we discuss possible reasons for this discrepancy.Comment: 31 pages, 7 figures, 4 tables. Accepted for publication on the
journal ICARUS, "Dark and Bright Materials on Vesta" special issu
Olivine or Impact Melt: Nature of the "Orange" Material on Vesta from Dawn
NASA's Dawn mission observed a great variety of colored terrains on asteroid
(4) Vesta during its survey with the Framing Camera (FC). Here we present a
detailed study of the orange material on Vesta, which was first observed in
color ratio images obtained by the FC and presents a red spectral slope. The
orange material deposits can be classified into three types, a) diffuse ejecta
deposited by recent medium-size impact craters (such as Oppia), b) lobate
patches with well-defined edges, and c) ejecta rays from fresh-looking impact
craters. The location of the orange diffuse ejecta from Oppia corresponds to
the olivine spot nicknamed "Leslie feature" first identified by Gaffey (1997)
from ground-based spectral observations. The distribution of the orange
material in the FC mosaic is concentrated on the equatorial region and almost
exclusively outside the Rheasilvia basin. Our in-depth analysis of the
composition of this material uses complementary observations from FC, the
visible and infrared spectrometer (VIR), and the Gamma Ray and Neutron Detector
(GRaND). Combining the interpretations from the topography, geomorphology,
color and spectral parameters, and elemental abundances, the most probable
analog for the orange material on Vesta is impact melt
Lymphome T cutané et systémique traité avec succès par greffe haplo-identique
BACKGROUND: Herein, we report a case of systemic cutaneous T-cell lymphoma refractory to standard therapy, the course of which resulted in haplo-identical bone marrow grafting.
PATIENTS AND METHODS: A 53-year-old woman consulted for facial erythema with infiltration, keratotic lesions on the trunk, and adenopathies measuring around 1cm on the axilla and inguinal folds. A diagnosis was made of Sézary syndrome (SS), a leukaemic form of epidermotropic cutaneous T-cell lymphoma. After three years of treatment with methotrexate, the patient developed transformed SS with visceral involvement. Given the high risk of relapse and the absence of an HLA-compatible donor, haploidentical bone marrow grafting was performed. The patient was still in complete remission two and a half years later. The disease course was nevertheless marked by the emergence one year after grafting of a Blaschko-distributed lichenoid eruption having histological features consistent with chronic graft-versus-host disease (GVHD); treatment with topical betamethasone proved efficacious.
DISCUSSION: To our knowledge, this is the first reported case of haploidentical grafting for systemic and transformed cutaneous T-cell lymphoma. This approach could henceforth represent a therapeutic option for patients requiring an allograft in the absence of compatible donors. The Blaschko-distributed lichenoid lesions attributed to chronic GVHD could be the result of reduced immune tolerance to abnormal embryological clones leading to a T-lymphocyte-mediated inflammatory reaction
41 GHz and 10.6 GHz low threshold and low noise InAs/InP quantum dash two-section mode-locked lasers in L band
International audienceThis paper reports recent results on InAs/InP quantum dash-based, two-section, passively mode- locked lasers pulsing at 41 GHz and 10.6 GHz and emitting at 1.59 lm at 20°C. The 41-GHz device (1 mm long) starts lasing at 25 mA under uniform injection and the 10.6 GHz (4 mm long) at 71 mA. Their output pulses are significantly chirped. The 41-GHz laser exhibits 7 ps pulses after propagation in 60 m of a single-mode fiber. The 10.6-GHz laser generates one picosecond pulses with 545 m of a single-mode fiber. Its single side-band phase noise does not exceed -80 dBc/Hz at 100 kHz offset, leading to an average timing jitter of 800 fs
Longitudinal Profile Monitor Using Smith-Purcell Radiation: Recent Results from the E-203 Collaboration
TUPC38 - Work supported by seed funding from the John Fell Fund, University of Oxford, Université Paris-Sud, program "Attractivité" and by the ANR under contract ANR-12-JS05-0003-01International audienceWe report on recent measurements made at FACET by the E-203 collaboration to test a longitudinal bunch profile monitor based on Coherent Smith-Purcell radiation. The capacity of this monitor to resolve sub-picosecond bunches will be shown as well as a comparison of profile reconstructed for different beam compression settings. We will also present recent electromagnetic simulations of the interactions between the beam and the grating as well as the expected resolution of such monitor. Comparison between Coherent Smith-Purcell radiation measurement and those made with other techniques will also be discussed. Finally future upgrades of the experiment and steps toward the construction of a single shot longitudinal profile monitor will be presented
Overcoming the Challenges Associated with Image-based Mapping of Small Bodies in Preparation for the OSIRIS-REx Mission to (101955) Bennu
The OSIRIS-REx Asteroid Sample Return Mission is the third mission in NASA's
New Frontiers Program and is the first U.S. mission to return samples from an
asteroid to Earth. The most important decision ahead of the OSIRIS-REx team is
the selection of a prime sample-site on the surface of asteroid (101955) Bennu.
Mission success hinges on identifying a site that is safe and has regolith that
can readily be ingested by the spacecraft's sampling mechanism. To inform this
mission-critical decision, the surface of Bennu is mapped using the OSIRIS-REx
Camera Suite and the images are used to develop several foundational data
products. Acquiring the necessary inputs to these data products requires
observational strategies that are defined specifically to overcome the
challenges associated with mapping a small irregular body. We present these
strategies in the context of assessing candidate sample-sites at Bennu
according to a framework of decisions regarding the relative safety,
sampleability, and scientific value across the asteroid's surface. To create
data products that aid these assessments, we describe the best practices
developed by the OSIRIS-REx team for image-based mapping of irregular small
bodies. We emphasize the importance of using 3D shape models and the ability to
work in body-fixed rectangular coordinates when dealing with planetary surfaces
that cannot be uniquely addressed by body-fixed latitude and longitude.Comment: 31 pages, 10 figures, 2 table
USF-1 Is Critical for Maintaining Genome Integrity in Response to UV-Induced DNA Photolesions
An important function of all organisms is to ensure that their genetic material remains intact and unaltered through generations. This is an extremely challenging task since the cell's DNA is constantly under assault by endogenous and environmental agents. To protect against this, cells have evolved effective mechanisms to recognize DNA damage, signal its presence, and mediate its repair. While these responses are expected to be highly regulated because they are critical to avoid human diseases, very little is known about the regulation of the expression of genes involved in mediating their effects. The Nucleotide Excision Repair (NER) is the major DNA–repair process involved in the recognition and removal of UV-mediated DNA damage. Here we use a combination of in vitro and in vivo assays with an intermittent UV-irradiation protocol to investigate the regulation of key players in the DNA–damage recognition step of NER sub-pathways (TCR and GGR). We show an up-regulation in gene expression of CSA and HR23A, which are involved in TCR and GGR, respectively. Importantly, we show that this occurs through a p53 independent mechanism and that it is coordinated by the stress-responsive transcription factor USF-1. Furthermore, using a mouse model we show that the loss of USF-1 compromises DNA repair, which suggests that USF-1 plays an important role in maintaining genomic stability
Mapping Vesta: First Results from Dawn’s Survey Orbit
The geologic objectives of the Dawn Mission [1] are
to derive Vesta’s shape, map the surface geology,
understand the geological context and contribute to
the determination of the asteroids’ origin and
evolution.Geomorphology and distribution of surface features
will provide evidence for impact cratering, tectonic activity, volcanism, and regolith processes. Spectral
measurements of the surface will provide evidence of
the compositional characteristics of geological units.
Age information, as derived from crater sizefrequency
distributions, provides the stratigraphic
context for the structural and compositional mapping
results, thus revealing the geologic history of Vesta.
We present here the first results of the Dawn mission
from data collected during the approach to Vesta, and
its first discrete orbit phase – the Survey Orbit, which
lasts 21 days after the spacecraft had established a
circular polar orbit at a radius of ~3000 km with a
beta angle of 10°-15°
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