P16-52. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism

International audiencen.

Brorfelde Schmidt CCD Catalog (BSCC)

The Brorfelde Schmidt CCD Catalog (BSCC) contains about 13.7 million stars, north of +49 deg Declination with precise positions and V, R photometry. The catalog has been constructed from the reductions of 18,667 CCD frames observed with the Brorfelde Schmidt Telescope between 2000 and 2007. The Tycho-2 catalog was used for astrometric and photometric reference stars. Errors of individual positions are about 20 to 200 mas for stars in the R = 10 to 18 mag range. External comparisons with 2MASS and SDSS reveal possible small systematic errors in the BSCC of up to about 30 mas. The catalog is supplemented with J, H, and K_s magnitudes from the 2MASS catalog. The catalog data file (about 550 MB ASCII, compressed) will be made available at the Strasbourg Data Center (CDS).Comment: 16 pages, 22 figures, 2 tables, accepted by A

SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH

Many studies estimate that chromosomal mosaicism within the cleavage-stage human embryo is high. However, comparison of two unique methods of aneuploidy screening of blastomeres within the same embryo has not been conducted and may indicate whether mosaicism has been overestimated due to technical inconsistency rather than the biological phenomena. The present study investigates the prevalence of chromosomal abnormality and mosaicism found with two different single cell aneuploidy screening techniques. Thirteen arrested cleavage-stage embryos were studied. Each was biopsied into individual cells (n = 160). The cells from each embryo were randomized into two groups. Those destined for FISH-based aneuploidy screening (n = 75) were fixed, one cell per slide. Cells for SNP microarray-based aneuploidy screening (n = 85) were put into individual tubes. Microarray was significantly more reliable (96%) than FISH (83%) for providing an interpretable result (P = 0.004). Markedly different results were obtained when comparing microarray and FISH results from individual embryos. Mosaicism was significantly less commonly observed by microarray (31%) than by FISH (100%) (P = 0.0005). Although FISH evaluated fewer chromosomes per cell and fewer cells per embryo, FISH still displayed significantly more unique genetic diagnoses per embryo (3.2 ± 0.2) than microarray (1.3 ± 0.2) (P < 0.0001). This is the first prospective, randomized, blinded and paired comparison between microarray and FISH-based aneuploidy screening. SNP microarray-based 24 chromosome aneuploidy screening provides more complete and consistent results than FISH. These results also suggest that FISH technology may overestimate the contribution of mitotic error to the origin of aneuploidy at the cleavage stage of human embryogenesis

New UltraCool and Halo White Dwarf Candidates in SDSS Stripe 82

A 2.5 x 100 degree region along the celestial equator (Stripe 82) has been imaged repeatedly from 1998 to 2005 by the Sloan Digital Sky Survey. A new catalogue of ~4 million light-motion curves, together with over 200 derived statistical quantities, for objects in Stripe 82 brighter than r~21.5 has been constructed by combining these data by Bramich et al. (2007). This catalogue is at present the deepest catalogue of its kind. Extracting the ~130000 objects with highest signal-to-noise ratio proper motions, we build a reduced proper motion diagram to illustrate the scientific promise of the catalogue. In this diagram disk and halo subdwarfs are well-separated from the cool white dwarf sequence. Our sample of 1049 cool white dwarf candidates includes at least 8 and possibly 21 new ultracool H-rich white dwarfs (T_eff < 4000K) and one new ultracool He-rich white dwarf candidate identified from their SDSS optical and UKIDSS infrared photometry. At least 10 new halo white dwarfs are also identified from their kinematics.Comment: 10 pages, 5 figures, published in MNRAS, minor text changes, final versio

What's in a name?: a discussion paper on the labels and location of self-organising community groups, with particular reference to mental health and Black groups

This article discusses the labelling and location of self-organising community groups – ‘self-help’, ‘peer support’ and ‘service user’. It notes the increasingly close relationship between these groups and statutory authorities, and how this relationship may put the benefits of the groups at risk. Historical, cultural and social factors are discussed to help explain differences and separate developments within African, Caribbean and other Black communities

Light and Motion in SDSS Stripe 82: The Catalogues

We present a new public archive of light-motion curves in Sloan Digital Sky Survey (SDSS) Stripe 82, covering 99 deg in right ascension from RA = 20.7 h to 3.3 h and spanning 2.52 deg in declination from Dec = -1.26 to 1.26 deg, for a total sky area of ~249 sq deg. Stripe 82 has been repeatedly monitored in the u, g, r, i and z bands over a seven-year baseline. Objects are cross-matched between runs, taking into account the effects of any proper motion. The resulting catalogue contains almost 4 million light-motion curves of stellar objects and galaxies. The photometry are recalibrated to correct for varying photometric zeropoints, achieving ~20 mmag and ~30 mmag root-mean-square (RMS) accuracy down to 18 mag in the g, r, i and z bands for point sources and extended sources, respectively. The astrometry are recalibrated to correct for inherent systematic errors in the SDSS astrometric solutions, achieving ~32 mas and ~35 mas RMS accuracy down to 18 mag for point sources and extended sources, respectively. For each light-motion curve, 229 photometric and astrometric quantities are derived and stored in a higher-level catalogue. On the photometric side, these include mean exponential and PSF magnitudes along with uncertainties, RMS scatter, chi^2 per degree of freedom, various magnitude distribution percentiles, object type (stellar or galaxy), and eclipse, Stetson and Vidrih variability indices. On the astrometric side, these quantities include mean positions, proper motions as well as their uncertainties and chi^2 per degree of freedom. The here presented light-motion curve catalogue is complete down to r~21.5 and is at present the deepest large-area photometric and astrometric variability catalogue available.Comment: MNRAS accepte

Conceptualisations of children’s wellbeing at school: the contribution of recognition theory

A large study in Australian schools aimed to elucidate understandings of ‘wellbeing’ and of factors in school life that contribute to it. Students and teachers understood wellbeing primarily, and holistically, in terms of interpersonal relationships, in contrast to policy documents which mainly focused on ‘problem areas’ such as mental health. The study also drew on recognition theory as developed by the social philosopher Axel Honneth. Results indicate that recognition theory may be useful in understanding wellbeing in schools, and that empirical research in schools may give rise to further questions regarding theory

First Results from Pan-STARRS1: Faint, High Proper Motion White Dwarfs in the Medium-Deep Fields

The Pan-STARRS1 survey has obtained multi-epoch imaging in five bands (Pan-STARRS1 gps, rps, ips, zps, and yps) on twelve "Medium Deep Fields", each of which spans a 3.3 degree circle. For the period between Apr 2009 and Apr 2011 these fields were observed 50-200 times. Using a reduced proper motion diagram, we have extracted a list of 47 white dwarf (WD) candidates whose Pan-STARRS1 astrometry indicates a non-zero proper motion at the 6-sigma level, with a typical 1-sigma proper motion uncertainty of 10 mas/yr. We also used astrometry from SDSS (when available) and USNO-B to assess our proper motion fits. None of the WD candidates exhibits evidence of statistically significant parallaxes, with a typical 1-sigma uncertainty of 8 mas. Twelve of these candidates are known WDs, including the high proper motion (1.7"/yr) WD LHS 291. We confirm three more objects as WDs through optical spectroscopy. Based on the Pan-STARRS1 colors, ten of the stars are likely to be cool WDs with 4170 K Teff 5000 K and cooling ages <9 Gyr. We classify these objects as likely thick disk WDs based on their kinematics. Our current sample represents only a small fraction of the Pan-STARRS1 data. With continued coverage from the Medium Deep Field Survey and the 3pi survey, Pan-STARRS1 should find many more high proper motion WDs that are part of the old thick disk and halo.Comment: 33 pages, 8 figures, submitted to Ap

High-Redshift Quasars Found in Sloan Digital Sky Survey Commissioning Data III: A Color Selected Sample at i^*<20 in the Fall Equatorial Stripe

This is the third paper in a series aimed at finding high-redshift quasars from five-color (u'g'r'i'z') imaging data taken along the Celestial Equator by the SDSS during its commissioning phase. In this paper, we first present the observations of 14 bright high-redshift quasars (3.66<z<4.77, i^*<20) discovered in the SDSS Fall Equatorial Stripe, and the SDSS photometry of two previously known high-redshift quasars in the same region of the sky. Combined with the quasars presented in previous papers, we define a color-selected flux-limited sample of 39 quasars at 3.6 < z < 5.0 and i^*<20, covering a total effective area of 182 deg^2. From this sample, we estimate the average spectral power law slope in the rest-frame ultraviolet for quasars at z~4 to be -0.79 with a standard deviation of 0.34, and the average rest-frame equivalent width of the Ly alpha+N V emission line to be 69 A with a standard deviation of 18 A. The selection completeness of this multicolor sample is determined from the model colors of high-redshift quasars, taking into account the distributions of emission line strengths, intrinsic continuum slope, the line and continuum absorption from intervening material, and the effects of photometric errors. The average completeness of this sample is about 75%. The selection function calculated in this paper will be used to correct the incompleteness of this color-selected sample and to derive the high-redshift quasar luminosity function in a subsequent paper. In the Appendix, we present the observations of an additional 18 faint quasars (3.57<z<4.80, 20.1<i^*<20.8) discovered in the region on the sky that has been imaged twice. Several quasars presented in this paper exhibit interesting properties, including a radio-loud quasar at z=4.77, and a narrow-line quasar (FWHM = 1500 km s^-1) at z=3.57.Comment: AJ accepted (Jan 2001), with minor changes; high-resolution finding charts available at http://www.sns.ias.edu/~fan/papers/q3.p