Unravelling the forces underlying urban industrial agglomeration

As early as the 1920's Marshall suggested that firms co-locate in cities to reduce the costs of moving goods, people, and ideas. These 'forces of agglomeration' have given rise, for example, to the high tech clusters of San Francisco and Boston, and the automobile cluster in Detroit. Yet, despite its importance for city planners and industrial policy-makers, until recently there has been little success in estimating the relative importance of each Marshallian channel to the location decisions of firms. Here we explore a burgeoning literature that aims to exploit the co-location patterns of industries in cities in order to disentangle the relationship between industry co-agglomeration and customer/supplier, labour and idea sharing. Building on previous approaches that focus on across- and between-industry estimates, we propose a network-based method to estimate the relative importance of each Marshallian channel at a meso scale. Specifically, we use a community detection technique to construct a hierarchical decomposition of the full set of industries into clusters based on co-agglomeration patterns, and show that these industry clusters exhibit distinct patterns in terms of their relative reliance on individual Marshallian channels

Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy

published_or_final_versio

An accelerating high-latitude jet in Earth's core

Observations of the change in Earth's magnetic field, the secular variation, provide information on the motion of liquid metal within the core that is responsible for its generation. The very latest high-resolution observations from ESA's Swarm satellite mission show intense field change at high-latitude localised in a distinctive circular daisy-chain configuration centred on the north geographic pole. Here we explain this feature with a localised, non-axisymmetric, westwards jet of 420 km width on the tangent cylinder, the cylinder of fluid within the core that is aligned with the rotation axis and tangent to the solid inner core. We find that the jet has increased in magnitude by a factor of three over the period 2000--2016 to about 40 km/yr, and is now much stronger than typical large-scale flows inferred for the core. The current accelerating phase may be a part of a longer term fluctuation of the jet causing both eastwards and westwards movement of magnetic features over historical periods, and may contribute to recent changes in torsional wave activity and the rotation direction of the inner core

International Geomagnetic Reference Field: the eleventh generation

The eleventh generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2009 by the International Association of Geomagnetism and Aeronomy Working Group V-MOD. It updates the previous IGRF generation with a definitive main field model for epoch 2005.0, a main field model for epoch 2010.0, and a linear predictive secular variation model for 2010.0-2015.0. In this note the equations defining the IGRF model are provided along with the spherical harmonic coefficients for the eleventh generation. Maps of the magnetic declination, inclination and total intensity for epoch 2010.0 and their predicted rates of change for 2010.0-2015.0 are presented. The recent evolution of the South Atlantic Anomaly and magnetic pole positions are also examine

International Geomagnetic Reference Field: the eleventh generation

The eleventh generation of the International Geomagnetic Reference Field (IGRF)was adopted in December 2009 by the International Association of Geomagnetism and AeronomyWorking Group V-MOD. It updates the previous IGRF generation with a definitive main field model for epoch 2005.0, a main field model for epoch 2010.0, and a linear predictive secular variation model for 2010.0–2015.0. In this note the equations defining the IGRF model are provided along with the spherical harmonic coefficients for the eleventh generation. Maps of the magnetic declination, inclination and total intensity for epoch 2010.0 and their predicted rates of change for 2010.0–2015.0 are presented. The recent evolution of the South Atlantic Anomaly and magnetic pole positions are also examined