18 research outputs found

    Assessment of sexual abuse allegations in child custody cases.

    Get PDF

    HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies

    No full text
    Myeloid cells residing in the CNS and lymphoid tissues are targets for productive HIV-1 replication, and their infection contributes to the pathological manifestations of HIV-1 infection. The Envs can adopt altered configurations to overcome entry restrictions in macrophages via a more efficient and/or altered mechanism of engagement with cellular receptors. This review highlights evidence supporting an important role for macrophages in HIV-1 pathogenesis and persistence, which need to be considered for strategies aimed at achieving a functional or sterilizing cure. We also highlight that the molecular mechanisms underlying HIV-1 tropism for macrophages are complex, involving enhanced and/or altered interactions with CD4, CCR5, and/or CXCR4, and that the nature of these interactions may depend on the anatomical location of the virus

    Sapientia, 1972, Vol. XXVII, nº 105 (número completo)

    Get PDF
    Contenido: La reconquista del valor de la inteligencia, fundamento de la restauración del orden humano y de la cultura / Octavio N. Derisi – Verdad y enmascaramiento / Osvaldo Francella – Presupuestos filosóficos de la ascética rosminiana / Lorenza Dadomo – El problema del mal en Jacques Maritain / José A. Díaz – Notas y comentarios -- Bibliografí

    Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

    Get PDF
    Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques (RMs) is associated with chronic immune activation. To elucidate the mechanisms underlying this intriguing phenotype, we used high-density oligonucleotide microarrays to longitudinally assess host gene expression in SIV-infected SMs and RMs. We found that acute SIV infection of SMs was consistently associated with a robust innate immune response, including widespread upregulation of IFN-stimulated genes (ISGs) in blood and lymph nodes. While SMs exhibited a rapid resolution of ISG expression and immune activation, both responses were observed chronically in RMs. Systems biology analysis indicated that expression of the lymphocyte inhibitory receptor LAG3, a marker of T cell exhaustion, correlated with immune activation in SIV-infected RMs but not SMs. Our findings suggest that active immune regulatory mechanisms, rather than intrinsically attenuated innate immune responses, underlie the low levels of immune activation characteristic of SMs chronically infected with SIV
    corecore