(Des)regulación emocional en estudiantes universitarios: cuando la adicción a dispositivos móviles pasa factura

The research addresses the link between emotional dysregulation, nomophobia, and Instagram addiction in Chilean university students. A quantitative study of correlational scope was conducted with a non-experimental cross-sectional design. The sample consisted of 218 university students from south-central Chile, who answered the Difficulties in Emotional Regulation Scale (DERS-E), the Nomophobia questionnaire NMP-Q, the Berger Instagram Addiction Scale (BIAS) and reported some parameters of their Instagram account activity. The results account for multiple correlations between nomophobia and Instagram addiction with all dimensions of emotional dysregulation. The number of followers and posts on the Instagram platform did not correlate with the dimensions of emotional dysregulation, although they did show correlations with nomophobia and Instagram addiction. The number of followers, on the other hand, showed correlations with some dimensions of emotional dysregulation. The article closes with a discussion of the implications of the excessive use of mobile devices on the mental health and functioning of university students.La investigación aborda el vínculo entre la desregulación emocional, nomofobia (miedo a quedar sin dispositivo móvil) y adicción a Instagram en estudiantes universitarios chilenos. Se condujo un estudio cuantitativo de alcance correlacional con un diseño no experimental de corte transversal. La muestra consistió en 218 universitarios de la zona centro sur de Chile, quienes respondieron la Escala de Dificultades de Regulación Emocional (DERS-E), el cuestionario de Nomofobia NMP-Q, la Escala de Adicción a Instagram de Berger (BIAS) e informaron algunos parámetros de la actividad de sus cuentas en Instagram. Los resultados arrojaron correlaciones significativas entre nomofobia, adicción a Instagram y las dimensiones de la desregulación emocional. El número de seguidos y de publicaciones en la plataforma de Instagram no tuvo correlación con las dimensiones de la desregulación emocional, aunque sí evidenciaron correlaciones con la nomofobia y la adicción a Instagram. La cantidad de seguidores, por otra parte, mostró correlaciones con algunas dimensiones de la desregulación emocional. El artículo cierra con la discusión de las implicancias del uso desmedido de dispositivos móviles en la salud mental y funcionamiento de los estudiantes universitarios

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Prospects for γ\gamma-ray observations of the Perseus galaxy cluster with the Cherenkov Telescope Array

International audienceGalaxy clusters are expected to be dark matter (DM) reservoirs and storage rooms for the cosmic-ray protons (CRp) that accumulate along the cluster's formation history. Accordingly, they are excellent targets to search for signals of DM annihilation and decay at gamma-ray energies and are predicted to be sources of large-scale gamma-ray emission due to hadronic interactions in the intracluster medium. We estimate the sensitivity of the Cherenkov Telescope Array (CTA) to detect diffuse gamma-ray emission from the Perseus galaxy cluster. We perform a detailed spatial and spectral modelling of the expected signal for the DM and the CRp components. For each, we compute the expected CTA sensitivity. The observing strategy of Perseus is also discussed. In the absence of a diffuse signal (non-detection), CTA should constrain the CRp to thermal energy ratio within the radius $R_{500}$ down to about $X_{500}10^{27}$s for DM masses above 1 TeV. These constraints will provide unprecedented sensitivity to the physics of both CRp acceleration and transport at cluster scale and to TeV DM particle models, especially in the decay scenario