In vitro and ex vitro germination of three Handroanthus species (Bignoniaceae)

Handroanthus impetiginosus, H. lapacho and “H.ochraceuslapachos” se distribuyen en el NO Argentino y presentan inconvenientes de germinación y conservación en su ambiente natural. La germinación de semillas bajo condiciones controladas es una alternativa para asegurar la propagación de especies con este tipo de problemáticas. En el presente estudio integral, se analizó la germinación in vitroy ex vitro, las características de las semillas y la morfología de las plántulas de las tres especies de Handroanthusmencionadas. Para ello, se midió el largo y ancho de las semillas, el ancho de las alas de la cubierta seminal, el ancho y largo del cuerpo seminal y del embrión. El poder germinativo de las tres especies fue determinado durante 12 meses luego de la cosecha de las semillas. Fueron determinados los parámetros de las plántulas obtenidas in vitroy ex vitro. El tamaño de la semilla y embrión de H. impetiginosus

Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau

Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and disease progression, but the mechanisms underlying synaptic defects associated with Tau are unclear. In disease conditions, Tau mislocalizes into pre- and postsynaptic compartments; here we show that, under pathological conditions, Tau binds to presynaptic vesicles in Alzheimer's disease patient brain. We define that the binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3. In fly and mouse models of Tauopathy, reduction of Synaptogyrin-3 prevents the association of presynaptic Tau with vesicles, alleviates Tau-induced defects in vesicle mobility, and restores neurotransmitter release. This work therefore identifies Synaptogyrin-3 as the binding partner of Tau on synaptic vesicles, revealing a new presynapse-specific Tau interactor, which may contribute to early synaptic dysfunction in neurodegenerative diseases associated with Tau

Stakeholders' views and experiences of care and interventions for addressing frailty and pre-frailty:a meta-synthesis of qualitative evidence

Frailty is a common condition in older age and is a public health concern which requires integrated care and involves different stakeholders. This meta-synthesis focuses on experiences, understanding, and attitudes towards screening, care, intervention and prevention for frailty across frail and healthy older persons, caregivers, health and social care practitioners. Studies published since 2001 were identified through search of electronic databases; 81 eligible papers were identified and read in full, and 45 papers were finally included and synthesized. The synthesis was conducted with a meta-ethnographic approach. We identified four key themes: Uncertainty about malleability of frailty; Strategies to prevent or to respond to frailty; Capacity to care and person and family-centred service provision; Power and choice. A bottom-up approach which emphasises and works in synchrony with frail older people's and their families' values, goals, resources and optimisation strategies is necessary. A greater employment of psychological skills, enhancing communication abilities and tools to overcome disempowering attitudes should inform care organisation, resulting in more efficient and satisfactory use of services. Public health communication about prevention and management of frailty should be founded on a paradigm of resilience, balanced acceptance, and coping. Addressing stakeholders' views about the preventability of frailty was seen as a salient need

In vitro and ex vitro germination of three Handroanthus species (Bignoniaceae)

Handroanthus impetiginosus, H. lapacho and “H.ochraceuslapachos” se distribuyen en el NO Argentino y presentan inconvenientes de germinación y conservación en su ambiente natural. La germinación de semillas bajo condiciones controladas es una alternativa para asegurar la propagación de especies con este tipo de problemáticas. En el presente estudio integral, se analizó la germinación in vitroy ex vitro, las características de las semillas y la morfología de las plántulas de las tres especies de Handroanthusmencionadas. Para ello, se midió el largo y ancho de las semillas, el ancho de las alas de la cubierta seminal, el ancho y largo del cuerpo seminal y del embrión. El poder germinativo de las tres especies fue determinado durante 12 meses luego de la cosecha de las semillas. Fueron determinados los parámetros de las plántulas obtenidas in vitroy ex vitro. El tamaño de la semilla y embrión de H. impetiginosus.</p