Las declaraciones responsables y las comunicaciones en el Proyecto de Ley del Procedimiento Administrativo Común de las Administraciones Públicas

Esta contribución analiza esquemáticamente la regulación de las declaraciones responsables y de las comunicaciones que contiene el Proyecto de Ley del procedimiento administrativo común de las administraciones públicas (I) y realiza una valoración crítica de la misma (II). En particular, se subrayan las deficiencias del régimen de control (II.A); se critica la posible supresión de las comunicaciones con potestad de veto (II.B); se destacan las carencias que se advierten (II.C); y se cuestiona que una ley de procedimiento administrativo sea la sede idónea para regular la materia (II.D)

El municipio turístico de Andalucía: claves sustantivas de su nueva regulación

This paper studies the substantive aspects of the new andalusian regulation on tourist municipalities. The legal analysis of Decree 72/2017 allows us to conclude that quality is its main objective; that the declaration of «Tourist Municipality of Andalusia» is accentuated as a starting point and not as an arrival goal; and that the purpose of this regime is not to compensate the greater expenses that visitors affluence supposes but to maintain and elevate the tourist attraction of the municipality.Este trabajo estudia los aspectos sustantivos de la nueva regulación de Andalucía sobre los municipios turísticos. El análisis jurídico del Decreto 72/2017 permite concluir que la calidad es el principal objetivo de la norma; que se acentúa la consideración de la declaración de Municipio Turístico de Andalucía como un punto de partida y no una meta de llegada; y que la finalidad de este régimen no es compensar los mayores gastos que supone la afluencia de visitantes sino la de mantener y elevar el atractivo turístico del municipio

La elaboración de informes jurídicos: su redescubrimiento a la luz de la adquisición y desarrollo de competencias

The study justify that this technique is of particular interest for its suitability for the acquisition and development of instrumental, interpersonal and systemic competences, including the capacity for analysis and synthesis, the ability to organize and plan, the acquisition of management skills. of information, teamwork skills and research skills.El artículo versa sobre una acción formativa que trata sobre el adiestramiento en la realización de informes que reflejen el estado de la cuestión sobre un asunto determinado (a nivel legal, jurisprudencial y doctrinal). Los autores del estudio justifican que esta técnica reviste un particular interés por su idoneidad para la adquisición y desarrollo de competencias instrumentales, interpersonales y sistémicas, entre ellas la capacidad de análisis y síntesis, la capacidad de organizar y planificar, la adquisición de habilidades para la gestión de la información, habilidades para trabajar en equipo y habilidades de investigación

Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits

Neuroinflammation underlies neurodegenerative diseases. Herein, we test whether acute colon inflammation activates microglia and astrocytes, induces neuroinflammation, disturbs neuron intrinsic electrical properties in the primary motor cortex, and alters motor behaviors. We used a rat model of acute colon inflammation induced by dextran sulfate sodium. Inflammatory mediators and microglial activation were assessed in the primary motor cortex by PCR and immunofluorescence assays. Electrophysiological properties of the motor cortex neurons were determined by whole-cell patch-clamp recordings. Motor behaviors were examined using open-field and rotarod tests. We show that the primary motor cortex of rats with acute colon inflammation exhibited microglial and astrocyte activation and increased mRNA abundance of interleukin-6, tumor necrosis factor-alpha, and both inducible and neuronal nitric oxide synthases. These changes were accompanied by a reduction in resting membrane potential and rheobase and increased input resistance and action potential frequency, indicating motor neuron hyperexcitability. In addition, locomotion and motor coordination were impaired. In conclusion, acute colon inflammation induces motor cortex microglial and astrocyte activation and inflammation, which led to neurons’ hyperexcitability and reduced motor coordination performance. The described disturbances resembled some of the early features found in amyotrophic lateral sclerosis patients and animal models, suggesting that colon inflammation might be a risk factor for developing this disease.Ministerio de Ciencia e Innovación 18.06.07.3005 PID2019-105632RB-I00, Grant RTI-2018.099908-B-C21Agencia Estatal de Investigación AEI/10.13039/50110001103

Realfood and cancer: analysis of the reliability and quality of YouTube content

This study analyzes the quality and reliability of videos related to nutrition and cancer on YouTube. Study Design: An observational, retrospective, cross-sectional, time-limited study analyzing activity on the social network YouTube was proposed. Methods: The information from the videos was extracted through an API search tool, using the NodeXL software. The criteria to select the videos on YouTube were the keywords “real food”, “realfood”, and “cancer” and the hashtags #realfood and #cancer were present, videos in English and videos available on 1 December 2022. Results: The DISCERN value in the total number of videos viewed was 2.25 (±0.88) points, indicating low reliability. The videos uploaded by HRU represented only 20.8%. Videos suggesting that the use of foods defined as “real food” could cure cancer without the intervention of any other treatment accounted for 12.5%. Videos that provided external links to scientific/technical evidence verifying the information represented only 13.89% of the total number of videos. Of these videos, 70% corresponded to HRU. The DISCERN value for videos from HRU users was 3.05 (0.88), a value that reflects a good reliability of videos from these users. Conclusions: This study provides information on the content and quality of the videos that we can find on YouTube. We found videos of non-health users who do not base their content on any scientific evidence, with the danger that this entails for the population, but it also highlights that the videos published by HRU have greater reliability and quality, being better perceived by the population, so it is important to encourage healthcare professionals and health institutions to share verified information on YouTube.This research was funded by Fundación Banco Santander and Fundación Alfonso X el Sabio, grant number 1014011. Partial funding for open access charge: Universidad de Málag

El tabaquismo en los pacientes de hemodiálisis. Prevalencia de consumo y actitudes

El objetivo del estudio es conocer la prevalencia y las características del hábito tabáquico en los pacientes incluidos en hemodiálisis en nuestra provincia y estudiar así mismo, algunas actitudes y conocimientos relacionadas con este hábito que nos orienten en la creación de un Plan Sanitario para la disminución del consumo de tabaco en los pacientes de diálisis

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Raíces y alas: recuerdos y ficciones

El segundo número de la colección Laboratorio Transmedia (ISSN: 2794-0861) contiene 36 relatos escritos durante el curso 2021/2022 por estudiantes de la Universidad para Mayores