Assessment of Hupu Gum for its Mucoadhesive Property in the Design and Evaluation of Mucoadhesive Buccal Patches of Propranolol HCl

ABSTRACT Objectives: There are no reports about assessment of the mucoadhesive property of formaldehyde treated hupu gum (HG). Hence the present study was undertaken to assessment of its mucoadhesive property of hupu gum in design of mucoadhesive buccal patches of Propanolol Hcl as a model drug. Methods: The prepared mucoadhesive buccal patches were compared with known muccoadhesive polymer, such as polyethylene oxide N 750. Poloxamer 407 is used as a penetration enhancer. The various physicomechanical parameters such as weight variation, folding endurance, thickness, surface pH, drug content, swelling studies and various ex vivo mucoadhesion parameters like mucoadhesive strength and force of adhesion were evaluated. In vitro diffusion studies as well as ex vivo drug release studies were performed. Results and conclusion: The results of the present investigation concluded that the formaldehyde treated hupu gum used as mucoadhesive polymer in development of buccal patches of propranolol Hcl were prepared by solvent casting method. Hupu gum is highly viscous, difficult to form buccal patches, due to this reason it is exposed to formaldehyde for 1hr to reduce its swelling nature. However, the variation in the release profile of propranolol Hcl due to different in the drug to polymer ratio. Finally, concluded that the formaldehyde treated hupu gum used as a mucoadhesive polymer