25 research outputs found
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
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- Adda M
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- Adrie C
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- Ahn MY
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- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
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- AKI Research Group
- Akiduki N
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- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
- Kouatchet A
- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
- Ku NS
- Ku NS
- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
- Kye YC
- Kyle UG
- Kyle UG
- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
- Lai CH
- Lake K
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- Lapteva K
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- Latini R
- Latini R
- Latini R
- Latorre J
- Lattuada M
- Lattuada M
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- Laurent A
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- Le Brocque R
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- Lebiedz P
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- Lee EY
- Lee JH
- Lee S
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- Lee SJ
- Lee WY
- Lee YJ
- Lee YJ
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- Legrand M
- Legrand M
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- Leitao AL
- Leite RT
- Leonard H
- Leone M
- Leone M
- Lerma FA
- Lesmes SP
- Lesmes SP
- Lesmes SP
- Lesmes SP
- Lesmes SP
- Lesmes SP
- Letizia T
- Levrat Q
- Levy B
- León JL
- León JP
- León JP
- León JP
- Lheureux O
- Lheureux O
- Lheureux O
- Lheureux O
- Li R
- Li SH
- Liao X
- Lichtenstein D
- Lim TH
- Limuti R
- Lin KC
- Lin KC
- Lin KC
- Lin KC
- Lin KL
- Lin PH
- Lin SC
- Lin SC
- Lin SC
- Lin SC
- Lin WC
- Lin WC
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- Lischinsky A
- Lissonde F
- Lissonde F
- Litchfield K
- Liu CP
- Liu CP
- Liu CP
- Liu CP
- Liu D
- Llaurado-Serra M
- Llorente B
- Llorente MÁ
- Lobato MS
- Lobo-Civico A
- Loizou C
- Lombardo MD
- Londoño JG
- Longani N
- Longhi L
- Lopes JA
- Lopez GD
- Lopez R
- Lopez-Caler C
- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
- Lortat-Jacob B
- Lotay R
- Loudet CI
- Louf-Durier A
- Louf-Durier A
- Louis B
- Lourido CM
- Lozano JA
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- Lucendo AP
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- Lucinio NM
- Luini M
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- Lukaszewicz AC
- Luna RR
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- Lusk J
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- Lázaro AS
- López AR
- López L
- López MA
- Macfarlane B
- MacKay A
- MacKay A
- Mackey G
- Mackey G
- MacPhee I
- Macrì M
- Madueño VP
- Maekawa K
- Maekawa K
- Maekawa K
- Maekawa K
- Maertens B
- Maggiorini M
- Maghsoudi B
- Magnanimi E
- Magnoni S
- Magret M
- Mainardi JL
- Maistry N
- Maitra S
- Makiko S
- Malagurski B
- Malek F
- Malo LR
- Maly M
- Malyshev A
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- Mancebo J
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- Mancino A
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- Marcos-Zambrano LJ
- Mariani M
- Mariman A
- Marin-Mateos H
- Marine-Vidal J
- Mariotte E
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- Marmanidou K
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- Martinez-Reyes L
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- Martínez F
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- Martínez-Carmona JF
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- Melo N
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- Mendonca AV
- Mendsaikhan N
- Menendez R
- Mengelle C
- Mercat A
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- Mergulhão PJ
- Merino-Vega D
- Messenger D
- Mezidi M
- Mezidi M
- Michel L
- Midwinter MJ
- Mignot T
- Miguelena PR
- Mihara Y
- Millar M
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- Mimoz O
- Min A
- Min HJ
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- Miranda F
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- Mistry M
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- Mitchell M
- Mitchell S
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- Mizugaki A
- Mizugaki A
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- Olaechea P
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- Philips BJ
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- Radu V
- Rai S
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- Rodríguez FG
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- Romero I
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- Spahn DR
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- Spijkstra JJ
- Spronk PE
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- Sprung CL
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- Stamm J
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- Stanić R
- Starczewska M
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- Stiphout C
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- Stocchetti N
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- Stretti F
- Struijs A
- Stubbs C
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- Stümpfle R
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- Su PL
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- Suchomel P
- Suh GJ
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- Suh JW
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- Sun WZ
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- Suzuki T
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- Sánchez B
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- Sánchez EC
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- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
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- Taccone FS
- Taccone FS
- Taccone FS
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- Taggu A
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- Takaki S
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- Takeda M
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- Takei T
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- Tamura T
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- Tanaka S
- Tanaka S
- Tane N
- Tang KB
- Tang LK
- Tapia A
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- Tapponnier R
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- Temprano-Gómez I
- Tena SA
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- Terzi N
- Terzi N
- Terzi N
- Terzi N
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- Thabut G
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- Thompson E
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- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
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- Tomas E
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- Tonetti T
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- Wijayatilake DS
- Wildenberg L
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- Winder-Rhodes S
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- Yamaguchi Y
- Yamamoto H
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- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
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- Yebenes JC
- Yeh YC
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- Yergaliyeva A
- Yılmaz G
- Yilmazer F
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- Yoruk F
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- Yoshitake E
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- Zabini D
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- Zaien I
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- Zanello M
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- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
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- Akatova E
- Akhter F
- Ako J
- Akright L
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- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
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- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
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- Amuchastegui M
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- Armaganijan L
- Arroyo JAC
- Arstall MA
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- Athyros V
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- Ball E
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- Barakovic F
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- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
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- Berglund S
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- Bittner VA
- Blicharski T
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- Blumberg EDS
- Boccara F
- Bodanese LC
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- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
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- Botelho A
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- Cheng S-C
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- Christenson S
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- Chumburidze V
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- Gremmler U
- Grewal JS
- Griffiths H
- Gring C
- Groenemeijer BE
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- Guardigli G
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- Guha S
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- Guzman PN
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- Hagstrom E
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- Halcox J
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- Hwang J-J
- II TC
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- Ilic S
- Ilieva-Pandeva KA
- Ince C
- Iniguez A
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- Iqbal SMR
- Irimpen A
- Istratoaie O
- Ito K
- Ivanov IG
- Ivanova R
- Ivanovic N
- Iyengar SS
- Izzo M
- Jacoby D
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- Jatin FGM
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- Jeserich M
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- Jintapakorn W
- Johansen PB
- Jonas M
- Jones WS
- Jordan JD
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- Joshi AB
- Joshi P
- Jovin I
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- Jujjuru S
- Jukema JW
- Juonala M
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- Jurgaitiene R
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- Kahali D
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- Kalashetti S
- Kalil R
- Kamensky G
- Kamiya H
- Kandasamy B
- Kapin T
- Kaplan R
- Kapp IE
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- Karna S
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- Karpov Y
- Karpov Y
- Kartalis A
- Kasim S
- Katona A
- Katsuda Y
- Katz A
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- Ke Y
- Keating F
- Kedev S
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- Knickelbine T
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- Kubilius R
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- Zuniga JDH
- Zurakowski A
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- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
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- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
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- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zapata G
- Zdravko B
- Zea Nunez CA
- Zeiher AM
- Zeiher AM
- Zhang R
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheleznyy V
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu C
- Zhu H
- Zhu J
- Zirlik A
- Zizka J
- Zobouyan I
- Zong W
- Zrazhevsky K
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring.
- Author
- Publication venue
- Springer Nature
- Publication date
- 07/07/2017
- Field of study
Contemporary cardiac and heart rate monitoring devices capture physiological signals using optical and electrode-based sensors. However, these devices generally lack the form factor and mechanical flexibility necessary for use in ambulatory and home environments. Here, we report an ultrathin (~1 mm average thickness) and highly flexible wearable cardiac sensor (WiSP) designed to be minimal in cost (disposable), light weight (1.2 g), water resistant, and capable of wireless energy harvesting. Theoretical analyses of system-level bending mechanics show the advantages of WiSP's flexible electronics, soft encapsulation layers and bioadhesives, enabling intimate skin coupling. A clinical feasibility study conducted in atrial fibrillation patients demonstrates that the WiSP device effectively measures cardiac signals matching the Holter monitor, and is more comfortable. WiSP's physical attributes and performance results demonstrate its utility for monitoring cardiac signals during daily activity, exertion and sleep, with implications for home-based care
Combined Approach in a Large Placental Chorioangioma Case with Intratumoral Alcohol Injection, Cordocentesis, IU Transfusion, and Amnioreduction
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Symptomatic discoid lateral meniscus: a clinical and arthroscopic study in a Chinese population
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular and Cellular Mechanisms of KSHV Oncogenesis of Kaposi's Sarcoma Associated with HIV/AIDS
- Author
- A Sodhi
- AD Mutlu
- BA Ashlock
- C Bais
- C Bais
- C Casper
- C Swanton
- D Chen
- D Ganem
- D Roy
- DF Martin
- DO Croci
- DP Dittmer
- E Cesarman
- EA Mesri
- EA Mesri
- Enrique A. Mesri
- F Bihl
- FQ An
- G Stallone
- HB Koon
- HB Koon
- HH Chang
- HQ Nguyen
- I Guasparri
- JN Martin
- KK Jensen
- L Cancian
- L Coscoy
- L Wang
- Lucas E. Cavallin
- P Barozzi
- P Monini
- Pascal Goldschmidt-Clermont
- PJ Browning
- Q Ma
- Q Ma
- R Liu
- Richard C. Condit
- S Montaner
- SA Radkov
- SE Krown
- T Jones
- Y Aoki
- Y Chang
- Y Zhu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
State contract law and the use of accounting information in debt contracts
- Author
- A Beatty
- A Mian
- AM Costello
- B Klein
- C Armstrong
- C Honigsberg
- Colleen Honigsberg
- D Brown
- D Givoly
- D Larcker
- D Saavedra
- DJ Skinner
- DP Miller
- G Nini
- G Rodano
- Gil Sadka
- GL Priest
- HA Hong
- HB Christensen
- HB Christensen
- I Dichev
- J Francis
- J Li
- J Murfin
- J Qian
- J Zhang
- JK Aier
- M Gergen
- M Minnis
- MR Roberts
- N Li
- O Hart
- P Aghion
- P Asquith
- PR Demerjian
- PR Demerjian
- R Ball
- R La Porta
- R La Porta
- RH Coase
- S Chava
- S Hollander
- S Sanga
- SA Mansi
- Sharon P. Katz
- SJ Burton
- SJ Grossman
- Sunay Mutlu
- T Eisenberg
- T Eisenberg
- WG Heninger
- Y Qi
- Z Bozanic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cross-cultural adaptation and multi-centric validation of the Italian version of the Achilles tendon Total Rupture Score (ATRS)
- Author
- A Cacchio
- A Ganestam
- AA Stone
- Alberto Combi
- Alberto Grassi
- Alberto Vascellari
- CB Terwee
- CJ Gwaltney
- DE Beaton
- DG Froberg
- E Budiman-Mak
- E Kaya Mutlu
- EM Roos
- F Guillemin
- G Apolone
- Gian Luigi Canata
- HB Kitaoka
- JA Husted
- JL Fleiss
- K Nilsson-Helander
- LB Mokkink
- LJ Cronbach
- M Duracinsky
- MR Carmont
- N Maffulli
- NN Ansari
- Pietro Spennacchio
- PR Deshpande
- RG Marx
- RS Kearney
- RS Kearney
- Salvatore Bisicchia
- Silvio Patella
- Stefano Zaffagnini
- T Venditto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular studies and therapeutic targeting of Kaposi’s sarcoma herpesvirus (KSHV/HHV-8) oncogenesis
- Author
- A Sodhi
- A Sodhi
- AD Mutlu
- Brittany M. Ashlock
- C Bais
- C Bais
- C Boshoff
- C Casper
- D Ganem
- E Cesarman
- E Cesarman
- E Cesarman
- E Cesarman
- EA Mesri
- EA Mesri
- Enrique A. Mesri
- FC Zhou
- G Stallone
- HB Koon
- HJ Leung
- Howard J. Leung
- J Soulier
- JA Isler
- JJ Russo
- K Irani
- KA Sarosiek
- KK Jensen
- L Arvanitakis
- L Arvanitakis
- LE Raez
- Lucas E. Cavallin
- M Kurtoglu
- N Munshi
- Pascal J. Goldschmidt-Clermont
- PJ Browning
- Q Ma
- Q Ma
- Qi Ma
- R Kuppers
- R Yarchoan
- S Bhatt
- S Montaner
- S Montaner
- S Montaner
- TY Yang
- Y Chang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2013
- Field of study
Kaposi’s sarcoma herpesvirus or human herpesvirus-8 (KSHV/HHV-8) is the etiological agent of Kaposi’s sarcoma (KS), an AIDS-defining angioproliferative neoplasm that continues to be a major global health problem and, of primary effusion lymphoma (PEL), a rare incurable B-cell lymphoma. This review describes the research from our laboratory and its collaborators to uncover molecular mechanisms of viral oncogenesis in order to develop new pathogenesis-based therapies to the KSHV-induced AIDS malignancies KS and PEL. They include the discovery of the viral angiogenic oncogene G protein-coupled receptor (vGPCR), the development of mouse models of KSHV and oxidative stress-induced KS, the identification of the role of Rac1-induced ROS in viral oncogenesis of KS and the development of novel therapeutic approaches able to target both latent and lytic oncogenic KSHV infection