Reforma tributária: indicadores fiscais em cinco países da América Latina convidado especial: Carlos Mussi

Periodicidade irregularO periódico não reflete, necessariamente, as opiniões do BNDES. Informativo apenas para subsidiar análises da SFData de início e fim da coleção na biblioteca: dez. 1999 - ago. 200

Teoria da sinalização : impacto de programas de recompra de ações em companhias listadas brasileiras

Monografia (graduação)—Universidade de Brasília, Faculdade de Economia, Administração e Contabilidade, Departamento de Economia, 2014.O presente trabalho tem como principal objetivo analisar o impacto de anúncios de programas de recompra de ações nos preços das ações de empresas listadas na Bolsa de Valores, Mercadorias & Futuros (BM&FBovespa) entre o período de 01/01/2011 e 29/09/2014. Por meio de um estudo de evento com 238 anúncios buscou-se verificar a existência de retornos anormais acumulados significantes durante a janela de evento por meio de um modelo ajustado ao mercado e risco. Os resultados encontrados mostram retornos anormais significativos para a amostra original, e para diferentes segmentações, e corroboram a hipótese de sinalização (VERMAELEN, 1981) de estudos anteriores. ____________________________________________________________________________ ABSTRACTThis study investigates the impact of open market share repurchase programs on stock prices of companies listed in the Bolsa de Valores, Mercadorias & Futuros (BM&FBovespa) for the period between 01/01/2011 and 09/29/2014. The existence of significant accumulated abnormal returns during the event-window was tested using an event study with a sample containing 238 events. Results show significant accumulated abnormal returns for the original sample, as well as for different segmentations, and corroborate previous findings and the signaling hypothesis (VERMAELEN, 1981)

Cellular interactions in the tumor microenvironment: the role of secretome

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses.Agência financiadora Fundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) FAPESP 10/51168-0 12/06048-2 13/03839-1 National Council for Scientific and Technological Development (CNPq) CNPq 306216/2010-8 Fundacao para a Ciencia e a Tecnologia (FCT) UID/BIM/04773/2013 CBMR 1334info:eu-repo/semantics/publishedVersio

Effects of a recent urbanization event on coastal groundwater in the southeastern coast of Brazil: a case study of the Macaé municipality

As águas subterrêneas costeiras são extremamente vulneráveis a atividades localizadas no continente e   intrusão salina. Em países em desenvolvimento, a recente urbanização de muitas cidades costeiras ocorreu sem planejamento, levando a problemas como a sobre-explotação das águas subterrêneas, ausência de saneamento e contaminação química. Este estudo apresenta uma caracterização espacial e sazonal de aspectos químicos e microbiológicos das águas subterrêneas em uma região costeira urbanizada recentemente, discutindo a contaminação e a salinização desse recurso hídrico. A urbanização recente afeta tanto poços rasos quanto profundos pela presença extensiva de Escherichia coli e alguns valores de NO3 -, NH4 +, As and Pb superiores aos de referência da legislação. Em contraste, concentrações de ferro e manganˆês acima dos valores de referência foram relacionadas a um enriquecimento litológico, embora possam restringir o consumo da água subterrênea. Ao lado da contaminação química e microbiológica, a salinização dos aquíferos costeiros não representou uma ameaça para essa área, embora águas subterrêneas salobras tenham ocorrido em um poço, influenciado pela abertura de barra de uma lagoa costeira, que promoveu a intrusão salina no aquífero.Coastal groundwater is extremely vulnerable to land-based human activities and seawater intrusion. In Brazil, a developing country, several coastal cities are undergoing recent urbanization with no planning, giving rise to problems such as groundwater overexploitation, sanitation, and chemical contamination. This study provides seasonal and spatial groundwater chemical and microbiological characterization of a recently urbanized coastal region, discussing contamination and salinization. The recent urbanization event affected both shallow and deep wells represented by the extensive presence of Escherichia coli on groundwater and nitrate, ammonium, arsenic, and lead (NO3-, NH4+,As and Pb) levels above groundwater safety guidelines. In contrast, iron and manganese (Fe and Mn) concentrations above the safety limit were associated with lithological enrichment, but might also restrict groundwater consumption. In addition to chemical and microbiological contamination, salinization of coastal aquifers did not pose a threat in this shoreline, but brackish groundwater was found in one well influenced by a coastal lagoon sandbar opening that allowed seawater to enter the aquifer

A rabdomiólise está associada à febre dengue em um paciente lúpico

ResumoEsse relato descreve o caso de uma mulher com lúpus eritematoso sistêmico (LES) que sofreu rabdomiólise em seguida à sua infecção pelo vírus da dengue. Foram relatados apenas alguns casos de LES com manifestação de rabdomiólise, nenhum deles associados à febre dengue.A princípio, a paciente apresentava‐se com febre alta, mialgia, astenia muscular, leve cefaleia, poliartralgia e trombocitopenia, lembrando uma exacerbação lúpica, mas considerando que o número de pessoas infectadas pela dengue na época era alto e tendo em vista que os sintomas das duas condições são parecidos, foi solicitada sorologia para dengue. Trans‐corridos alguns dias, a paciente apresentou rabdomiólise, tendo então sido tratada com medicamentos imunossupressivos, alcalinização urinária e hidratação vigorosa, medidas que melhoraram seus danos musculares e a condição inflamatória. A sorologia positiva para dengue nos foi disponibilizada apenas depois da instauração do tratamento descrito acima. A paciente recebeu alta em estado assintomático.Esse caso demonstra a grande semelhança entre a febre dengue e uma exacerbação lúpica; isso deve alertar o clínico para que, especialmente durante uma epidemia, faça uma cuidadosa diferenciação entre essas doenças, de forma a estabelecer uma terapia correta e eficiente.AbstractThis report describes the case of a woman with systemic lupus erythematous (SLE) that developed rhabdomyolysis after being infected by dengue virus. There are only a few cases of SLE accompanied by rhabdomyolysis, none of them associated with dengue fever.Initially, the woman presented high fever, myalgia, muscular weakness, mild headache, polyarthralgia and thrombocytopenia reminding a lupus flare, but since the number of people infected by dengue at that time was high and the symptoms from both conditions are similar, a dengue serology was requested. After a few days, the patient developed rhabdomyolysis. She was then submitted to immunosuppressive drugs, urinary alkalization and vigorous hydration, which improved her muscle damage and inflammatory condition. The positive dengue serology was only available after the therapy above had been established. She was discharged in an asymptomatic state.This case demonstrates how alike dengue fever and a lupus flare are, warning clinicians that, especially during an epidemic, both diseases should be carefully differentiated in order to establish a correct and efficient therapy

Automatização de Acesso de Veículos à Estacionamentos

Technological advancement and the growing number of vehicles enable innovative solutions. The mission of this work is to bring up a computational response capable of detecting and recognizing automotive license plates, in order to control access in private areas, as well as the storage and availability of information generated from this solution. For this purpose, the OpenCv library was used to process the images. As a result, 43,3% of correct answers were obtained in the recognition of the detected plaques

Divulgação do risco operacional em corporações multinacionais bancárias: comparação entre subsidiárias brasileiras e matrizes estrangeiras

This work tries to verify the congruence level between the operational risk disclosure practices adopted by nine subsidiaries of multinational bank corporations that operate in Brazil and the operational risk disclosure practices adopted by the corresponding central offices in their countries of origin. The sample was selected based on the report ‘50 Maiores Bancos’ (50 Largest Banks), of the Central Bank of Brazil, December 2004. Data was collected from annual reports and other disclosure instruments from the years of 2003 and 2004. Content analysis was used and the elements of analysis were nine categories and eighteen sub-categories based on operational risk disclosure review. The Wilcoxon Test was used. It was verified that the congruence level between the operational risk disclosure adopted by central offices and their corresponding subsidiaries was of 29.63% in 2003 and 32.72% in 2004. The test result showed that the multinational bank corporations did not show differences between the 2003 and the 2004 congruence levels. In general, the results indicate that the operational risk disclosure practices that the subsidiaries adopted were different from the disclosure practices the corresponding foreign central offices adopted.Este trabalho busca verificar o grau de congruência entre a divulgação do risco operacional adotada por nove subsidiárias de corporações multinacionais bancárias que atuam no Brasil e a divulgação desse mesmo risco adotada pelas respectivas matrizes estrangeiras. O estudo é descritivo, contemplando revisão bibliográfica e pesquisa documental. Selecionou-se a amostra segundo relatório ’50 Maiores Bancos’, do Banco Central, de dezembro de 2004. Coletaram-se dados em relatórios anuais e outros instrumentos de divulgação, datas-base 2003 e 2004. Utilizou-se análise de conteúdo, baseado em nove categorias e dezoito subcategorias obtidas da revisão bibliográfica. Empregou-se o Teste de Wilcoxon. Verificou-se que o grau de congruência entre a divulgação da matriz e respectiva subsidiária foi 29,63% em 2003, e 32,72% em 2004. Não houve diferenças significativas entre os graus de congruência dos dois anos. Segundo esses resultados a divulgação do risco operacional adotada pelas subsidiárias foi diferente da divulgação adotada pelas respectivas matrizes estrangeiras

Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities

OBJECTIVES: To describe laboratory abnormalities among HIV-infected women and their infants with standard and increased lopinavir/ritonavir (LPV/r) dosing during the third trimester of pregnancy. METHODS: We evaluated data on pregnant women from NISDI cohorts (2002-2009) enrolled in Brazil, who received at least 28 days of LPV/r during the third pregnancy trimester and gave birth to singleton infants. RESULTS: 164 women received LPV/r standard dosing [(798/198 or 800/200 mg/day) (Group 1)] and 70 increased dosing [(> 800/200 mg/day) (Group 2)]. Group 1 was more likely to have advanced clinical disease and to use ARVs for treatment, and less likely to have CD4 counts > 500 cells/mm³. Mean plasma viral load was higher in Group 2. There were statistically significant, but not clinically meaningful, differences between groups in mean AST, ALT, cholesterol, and triglycerides. The proportion of women with Grade 3 or 4 adverse events was very low, with no statistically significant differences between groups in severe adverse events related to ALT, AST, total bilirubin, cholesterol, or triglycerides. There were statistically significant, but not clinically meaningful, differences between infant groups in ALT and creatinine. The proportion of infants with Grade 3 or 4 adverse events was very low, and there were no statistically significant differences in severe adverse events related to ALT, AST, BUN, or creatinine. CONCLUSION: The proportions of women and infants with severe laboratory adverse events were very low. Increased LPV/r dosing during the third trimester of pregnancy appears to be safe for HIV-infected women and their infants.Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NIH

Vitamin A, vitamin E, iron and zinc status in a cohort of HIV-infected mothers and their uninfected infants

Introduction We hypothesized that nutritional deficiency would be common in a cohort of postpartum, human immunodeficiency virus (HIV)-infected women and their infants. Methods Weight and height, as well as blood concentrations of retinol, α-tocopherol, ferritin, hemoglobin, and zinc, were measured in mothers after delivery and in their infants at birth and at 6-12 weeks and six months of age. Retinol and α-tocopherol levels were quantified by high performance liquid chromatography, and zinc levels were measured by atomic absorption spectrophotometry. The maternal body mass index during pregnancy was adjusted for gestational age (adjBMI). Results Among the 97 women 19.6% were underweight. Laboratory abnormalities were most frequently observed for the hemoglobin (46.4%), zinc (41.1%), retinol (12.5%) and ferritin (6.5%) levels. Five percent of the women had mean corpuscular hemoglobin concentrations \u3c 31g/dL. The most common deficiency in the infants was α-tocopherol (81%) at birth; however, only 18.5% of infants had deficient levels at six months of age. Large percentages of infants had zinc (36.8%) and retinol (29.5%) deficiencies at birth; however, these percentages decreased to 17.5% and 18.5%, respectively, by six months of age. No associations between infant micronutrient deficiencies and either the maternal adjBMI category or maternal micronutrient deficiencies were found. Conclusions Micronutrient deficiencies were common in HIV-infected women and their infants. Micronutrient deficiencies were less prevalent in the infants at six months of age. Neither underweight women nor their infants at birth were at increased risk for micronutrient deficiencies

Keratocystic odontogenic tumor: case report

Introdução: o tumor odontogênico ceratocístico (TOC) é uma lesão oral e maxilofacial relativamente comum que surge de restos da lâmina dental. Ele tem um comportamento agressivo, incluindo altas taxas de recorrência, crescimento rápido e extensão para os tecidos adjacentes. Várias modalidades de tratamento e, assim, diferentes taxas de recorrência após o tratamento, foram relatadas. Devido ao revestimento muito fino e friável, característica do tumor, a enucleação pode ser difícil e, por esta razão ele é associado com as maiores taxas de recorrência. Objetivo: o presente trabalho descreve um caso de um grande TOC no corpo mandibular, onde, devido à presença de um revestimento de espessura incomum, a remoção do tumor como uma peça única foi bem sucedida. Conclusão: o presente caso demonstra que TOC de grandes proporções podem ser tratados de maneira conservadora. Devido à possibilidade de recidiva em muitos anos após o tratamento inicial, acompanhamento a longo prazo é obrigatório. Palavras-chave: Tumor Odontogênico Queratocístico; Revestimento; Cirurgia Oral