Sequential pattern formation in a model for skin morphogenesis

During morphogenesis regular patterns often develop behind a frontier of pattern formation which travels across the prospective tissue. Here the authors consider the propagating patterns exhibited in a two-dimensional domain by a tissue interaction mechanochemical model for skin pattern formation. It is shown that the model can exhibit travelling waves of complex spatial pattern formation. Two alternative mechanisms that can produce such sequential patterning are presented. In particular, it is demonstrated that the specification of a simple quasi-one-dimensional pattern is all that is required to determine a complex two-dimensional pattern. Finally, the model solutions are related to actual pattern propagation during chick feather primordia initiation

The Impact of Early Positive Results on a Mathematics and Science Partnership: The Experience of the Institute for Chemistry Literacy Through Computational Science

After one year of implementation, the Institute for Chemistry Literacy through Computational Science, an NSF Mathematics and Science Partnership Institute Project led by the University of Illinois at Urbana-Champaign’s Department of Chemistry, College of Medicine, and National Center for Supercomputing Applications, experienced statistically significant gains in chemistry content knowledge among students of the rural high school teachers participating in its intensive, year-round professional development course, compared to a control group. The project utilizes a two-cohort, delayed-treatment, random control trial, quasi-experimental research design with the second cohort entering treatment one year following the first. The three-year treatment includes intensive two-week summer institutes, occasional school year workshops and year-round, on-line collaborative lesson development, resource sharing, and expert support. The means of student pre-test scores for Cohort I (η=963) and Cohort II (η=862) teachers were not significantly different. The mean gain (difference between pre-test and post-test scores) after seven months in the classroom for Cohort I was 9.8 percentage points, compared to 6.7 percentage points for Cohort II. This statistically significant difference (p\u3c.001) represented an effect size of .25 standard deviation units, and indicated unusually early confirmation of treatment effects. When post-tests were compared, Cohort I students scored significantly higher than Cohort II and supported the gain score differences. The impact of these results on treatment and research plans is discussed. concentrating on the effect of lessening rural teachers’ isolation and increasing access to tools to facilitate learning

Optimal stopping times for estimating Bernoulli parameters with applications to active imaging

We address the problem of estimating the parameter of a Bernoulli process. This arises in many applications, including photon-efficient active imaging where each illumination period is regarded as a single Bernoulli trial. We introduce a framework within which to minimize the mean-squared error (MSE) subject to an upper bound on the mean number of trials. This optimization has several simple and intuitive properties when the Bernoulli parameter has a beta prior. In addition, by exploiting typical spatial correlation using total variation regularization, we extend the developed framework to a rectangular array of Bernoulli processes representing the pixels in a natural scene. In simulations inspired by realistic active imaging scenarios, we demonstrate a 4.26 dB reduction in MSE due to the adaptive acquisition, as an average over many independent experiments and invariant to a factor of 3.4 variation in trial budget.Accepted manuscrip

Travelling waves in a tissue interaction model for skin pattern formation

Tissue interaction plays a major role in many morphogenetic processes, particularly those associated with skin organ primordia. We examine travelling wave solutions in a tissue interaction model for skin pattern formation which is firmly based on the known biology. From a phase space analysis we conjecture the existence of travelling waves with specific wave speeds. Subsequently, analytical approximations to the wave profiles are derived using perturbation methods. We then show numerically that such travelling wave solutions do exist and that they are in good agreement with our analytical results. Finally, the biological implications of our analysis are discussed

Beyond Binomial and Negative Binomial: Adaptation in Bernoulli Parameter Estimation

Estimating the parameter of a Bernoulli process arises in many applications, including photon-efficient active imaging where each illumination period is regarded as a single Bernoulli trial. Motivated by acquisition efficiency when multiple Bernoulli processes are of interest, we formulate the allocation of trials under a constraint on the mean as an optimal resource allocation problem. An oracle-aided trial allocation demonstrates that there can be a significant advantage from varying the allocation for different processes and inspires a simple trial allocation gain quantity. Motivated by realizing this gain without an oracle, we present a trellis-based framework for representing and optimizing stopping rules. Considering the convenient case of Beta priors, three implementable stopping rules with similar performances are explored, and the simplest of these is shown to asymptotically achieve the oracle-aided trial allocation. These approaches are further extended to estimating functions of a Bernoulli parameter. In simulations inspired by realistic active imaging scenarios, we demonstrate significant mean-squared error improvements: up to 4.36 dB for the estimation of p and up to 1.80 dB for the estimation of log p.Comment: 13 pages, 16 figure

Probing the circulation of ring-shaped Bose-Einstein condensates

This paper reports the results of a theoretical and experimental study of how the initial circulation of ring-shaped Bose-Einstein condensates (BECs) can be probed by time-of-flight (TOF) images. We have studied theoretically the dynamics of a BEC after release from a toroidal trap potential by solving the 3D Gross-Pitaevskii (GP) equation. The trap and condensate characteristics matched those of a recent experiment. The circulation, experimentally imparted to the condensate by stirring, was simulated theoretically by imprinting a linear azimuthal phase on the initial condensate wave function. The theoretical TOF images were in good agreement with the experimental data. We find that upon release the dynamics of the ring--shaped condensate proceeds in two distinct phases. First, the condensate expands rapidly inward, filling in the initial hole until it reaches a minimum radius that depends on the initial circulation. In the second phase, the density at the inner radius increases to a maximum after which the hole radius begins slowly to expand. During this second phase a series of concentric rings appears due to the interference of ingoing and outgoing matter waves from the inner radius. The results of the GP equation predict that the hole area is a quadratic function of the initial circulation when the condensate is released directly from the trap in which it was stirred and is a linear function of the circulation if the trap is relaxed before release. These scalings matched the data. Thus, hole size after TOF can be used as a reliable probe of initial condensate circulation. This connection between circulation and hole size after TOF will facilitate future studies of atomtronic systems that are implemented in ultracold quantum gases.Comment: 9 pages, 9 figure

Cigarette smoking is associated with amplified age-related volume loss in subcortical brain regions

BACKGROUND: Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. METHODS: Non-smokers (n=43) and smokers (n=40), 22-70 years of age, completed a 4T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. RESULTS: Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. CONCLUSIONS: Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei. Greater cigarette quantity/exposure was related to smaller volumes in regions that also showed greater age-related volume loss in smokers. Findings suggest smoking adversely affected the structural integrity of subcortical brain regions with increasing age and exposure. The greater age-related volume loss in smokers may have implications for cortical-subcortical structural and/or functional connectivity, and response to available smoking cessation interventions

Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios

We extend the validity of the quasi-steady state assumption for a model double intermediate enzyme-substrate reaction to include the case where the ratio of initial enzyme to substrate concentration is not necessarily small. Simple analytical solutions are obtained when the reaction rates and the initial substrate concentration satisfy a certain condition. These analytical solutions compare favourably with numerical solutions of the full system of differential equations describing the reaction. Experimental methods are suggested which might permit the application of the quasi-steady state assumption to reactions where it may not have been obviously applicable before

Interplanetary propulsion using inertial fusion

Inertial fusion can be used to power spacecraft within the solar system and beyond. Such spacecraft have the potential for short-duration manned-mission performance exceeding other technologies. We are conducting a study to assess the systems aspects of inertial fusion as applied to such missions, based on the conceptual engine design of Hyde (1983) we describe the required systems for an entirely new spacecraft design called VISTA that is based on the use of DT fuel. We give preliminary design details for the power conversion and power conditioning systems for manned missions to Mars of total duration of about 100 days. Specific mission performance results will be published elsewhere, after the study has been completed